The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Drakon A.K.

Research Institute of Eye Diseases

Pateyuk L.S.

Krasnov Research Institute of Eye Diseases

Sheludchenko V.M.

Krasnov Research Institute of Eye Diseases

Korchazhkina N.B.

Russian research center of surgery named after academician B.V. Petrovsky;
The Moscow state medical University named after A.I. Evdokimov of the Ministry of health of Russia

Ocular iontophoresis

Authors:

Drakon A.K., Pateyuk L.S., Sheludchenko V.M., Korchazhkina N.B.

More about the authors

Journal: Russian Annals of Ophthalmology. 2021;137(6): 119‑127

Read: 26304 times


To cite this article:

Drakon AK, Pateyuk LS, Sheludchenko VM, Korchazhkina NB. Ocular iontophoresis. Russian Annals of Ophthalmology. 2021;137(6):119‑127. (In Russ.)
https://doi.org/10.17116/oftalma2021137061119

References:

  1. Ulashchik VS, Lukomskii IV. Obshchaya fizioterapiya: Uchebnik [General Physiotherapy: A Textbook]. Minsk: Knizhnyi Dom; 2008. (In Russ.).
  2. Ulashchik BC. Fizioterapiya. Universal’naya meditsinskaya entsiklopediya [Physiotherapy. Universal Medical Encyclopedia]. Minsk: Knizhnyi dom; 2008. (In Russ.).
  3. Lukomskii IV. Obshchaya fizioterapiya: kurs lektsii [General physiotherapy: course of lectures]. Vitebsk: Izdatel’stvo VGMU; 2001 (In Russ.).
  4. Kuroyedov AV, Brzhesky VV, Krinitsyna EA. Traditional, unfairly forgotten, rarely used and promising drug delivery methods in ophthalmology: a clinical interpretation (part 1). Russian Ophthalmological Journal = Rossiyskiy oftal’mologicheskiy zhurnal. 2019;12(2):83-95 (In Russ.). https://doi.org/10.21516/2072-0076-2019-12-2-83-95
  5. Kuroyedov AV, Brzhesky VV, Nagornova ZM. Traditional, unfairly forgotten, rarely used and promising drug delivery methods in ophthalmology: a clinical interpretation (Part 2). Russian Ophthalmological Journal = Rossiyskiy oftal’mologicheskiy zhurnal. 2019;12(4):83-91. (In Russ.). https://doi.org/10.21516/2072-0076-2019-12-4-83-91
  6. Ponomarenko GN, Turkovskii II. Biofizicheskie osnovy fizioterapii [Biophysical foundations of physiotherapy]. M.: Meditsina; 2006 (In Russ.).
  7. Egorov VV, Smolyakova GP, Kolenko OV. Fizioterapiya v oftal’mologii [Physiotherapy in ophthalmology]. Khabarovsk: IPKSZ; 2019 (In Russ.).
  8. Sosin IN, Levchenko OG. Fizioterapiya glaznykh boleznei [Physiotherapy of eye diseases]. Tashkent: Meditsina; 1988 (In Russ.).
  9. Polunin GS, Makarov IA. Fizioterapevticheskie metody v oftal’mologii [Physiotherapy methods in ophthalmology]. M.: MIA; 2015 (In Russ.).
  10. Okovitov VV. Metody fizioterapii v oftal’mologii [Physiotherapy methods in ophthalmology]. M.: Meditsina; 1999 (In Russ.).
  11. Damaskin BB, Petrii OA, Tsirlina GA. Elektrokhimiya [Electrochemistry]. M.: Khimiya, KolosS; 2006 (In Russ.).
  12. Kazarinov IA. Vvedenie v biologicheskuyu elektrokhimiyu. Uchebnoe posobie [Introduction to Biological Electrochemistry: A Study Guide]. Saratov: Izdatel’stvo Saratovskogo universiteta; 2012 (In Russ.).
  13. Khorunzhii VV, Srago IA. Koagulyatsiya. Elektrokineticheskie yavleniya. Metodicheskoe posobie dlya studentov po obshchei khimii [Coagulation. Electrokinetic phenomena. Methodological guide for students in general chemistry]. SPb.: Sankt-Peterburgskii gosudarstvennyi pediatricheskii meditsinskii universitet; 2018. (In Russ.).
  14. Baranov VYa, Frolov VI. Elektrokineticheskie yavleniya. Uchebnoe posobie [Electrokinetic phenomena. Tutorial]. M.: RGU nefti i gaza; 2002 (In Russ.).
  15. Roldugin VI. Lektsii po kolloidnoi khimii dlya studentov IV kursa Khimicheskogo fakul’teta. Khimicheskii fakul’tet MGU. Lektsiya 10. Elektrokineticheskie yavleniya [Lectures on colloidal chemistry for IV year students of the Faculty of Chemistry. Faculty of Chemistry, Moscow State University. Lecture 10. Electrokinetic phenomena]. Accessed 04.06.2021. (In Russ.). https://www.chem.msu.ru/rus/teaching/colloid-roldugin-lectures/10.pdf
  16. Nesterov AP, Basinsky SN. A new method of introducing drugs into the posterior part of the subtenon space. The Russian Annals of Ophthalmology = Vestnik oftal’mologii. 1991;(5):49-51 (In Russ.).
  17. Basinskii SN, Nesterov AP. Sposob vvedeniya lekarstvennykh preparatov [Method of drug administration]. RF patent for invention №2008858/1994.03.15. Bul. No. 5. Accessed 04.06.21. (In Russ.). https://patents.s3.yandex.net/RU2008858C1_19940315.pdf
  18. Oftal’mologiya. Natsional’noe rukovodstvo [Ophthalmology. National leadership]. Eds Avetisov S.E., Egorov E.A., Moshetova L.K., Neroeva V.V., Takhchidi Kh.P. M.: GEOTAR-Media; 2014 (In Russ.).
  19. Strakhov VV, Egorov EA, Erichev VP, Yartsev AV, Petrov SYu, Dorofeev DA. The influence of long-term retinal protective therapy on glaucoma progression according to structural and functional tests. The Russian Annals of Ophthalmology = Vestnik oftal’mologii. 2020;136(5):58-66. (In Russ.). https://doi.org/10.17116/oftalma202013605158
  20. Karpilova MA, Poluianova AD. Antioxidant nutraceuticals for glaucoma. The Russian Annals of Ophthalmology = Vestnik oftal’mologii. 2020;136(4):317-323. (In Russ.). https://doi.org/10.17116/oftalma2020136042317
  21. Erichev VP, Lovpache DN, Yaremenko TV. Peptide bioregulators: delivery and efficacy. The Russian Annals of Ophthalmology = Vestnik oftal’mologii. 2020;136(2):56-62. (In Russ.). https://doi.org/10.17116/oftalma202013602156
  22. Egorov EA, Erichev VP, Strakhov VV, Petrov SYu, Romanova TB, Vasina MV, Zinina VS, Makarova AS, Kazanova SYu, Yartsev AV. Structural and functional changes in the retina of patients with primary open-angle glaucoma and compensated intraocular pressure while undergoing retinoprotective therapy. The Russian Annals of Ophthalmology = Vestnik oftal’mologii. 2019;135(3):20-30. (In Russ.). https://doi.org/10.17116/oftalma201913503120
  23. Strakhov VV, Yartsev AV, Alekseev VV, Klimova ON, Kazanova SYu, Voronin NA. Structural and functional changes in the retinal layers in patients with primary glaucoma and possible means of retinoprotection. The Russian Annals of Ophthalmology = Vestnik oftal’mologii. 2019;135(2):70-82. (In Russ.). https://doi.org/10.17116/oftalma201913502170
  24. Malishevskaya TN, Yusupov AR, Shatskikh SV, Antipina NA, Klindyuk TS, Bogdanova DS. Efficacy and safety of neuroprotection in patients with primary open-angle glaucoma. The Russian Annals of Ophthalmology = Vestnik oftal’mologii. 2019;135(2):83-92. (In Russ.). https://doi.org/10.17116/oftalma201913502183
  25. Astakhov YuS, Kiryanova VV, Maksimov AV, Morozova NV, Sokolov VO, Florentseva SS. «Retinalamin» neuroprotective action assessment in treatment of primary open-angle glaucoma stages 1—2 by endonasal electrophoresis. Oftal’mologicheskie vedomosti. 2010;4(3):60. (In Russ.).
  26. Astakhov YuS, Butin EV, Morozova NV, Sokolov VO, Florentseva SS. An experience of retinalamin use in glaucomatous optic neuropathy and age-related macular degeneration. Oftal’mologicheskie vedomosti. 2013;6(2):45-49. (In Russ.).
  27. Astakhov YuS, Morozova NV, Sokolov VO, Florentseva SS. Experience of using endonasal electrophoresis of the neuropeptide «Retinalamin» in age-related macular degeneration of the dry form. In: Vostok—Zapad 2013: Sbornik nauchnykh trudov nauchno-prakticheskoi konferentsii po oftal’mokhirurgii s mezhdunarodnym uchastiem [East-West 2013: Collection of scientific papers of the scientific and practical conference on ophthalmosurgery with international participation]. Ufa; 2013. Accessed 04.06.2021. (In Russ.). https://eyepress.ru/article.aspx?13192
  28. Kurysheva NI, Shpak AA, Ioileva EE, Galanter LI, Nagornova ND, Shubina NYu, Slyshalova NN. Semax in the treatment of glaucomatous optic neuropathy in patients with normalized ophthalmotonus. The Russian Annals of Ophthalmology = Vestnik oftal’mologii. 2001;117(4):5-8. (In Russ.).
  29. Polunin GS, Sheremet NL, Nurieva SM, Myasoedov NF, Andreeva LA. Sredstvo i sposob lecheniya nevritov zritel’nogo nerva vospalitel’noy, toksiko-allergicheskoy, sosudistoy etiologii i atrofii zritel’nogo nerva [Means and method for treatment of optic neuritis of inflammatory, toxic-allergic, vascular etiology and of optic nerve atrophy]. RF patent for invention №2157258/10.10.2000. Accessed 04.06.21. (In Russ.). https://patentimages.storage.googleapis.com/b4/fc/ba/bcf070a94b2089/RU2157258C1.pdf
  30. Yurova OV, Linok VA, Turova EA, Morozova NE, Rogan OA, Nazarova GA. Sposob lecheniya bol’nykh s neproliferativnoy diabeticheskoy retinopatiyey [Method of treating patients with non-proliferative diabetic retinopathy]. RF patent for invention No. 2480252/27.04.2013. Bul. No. 12. Accessed 04.06.21. (In Russ.). https://patentimages.storage.googleapis.com/8a/b5/e9/6bc032145b9e32/RU2480252C1.pdf
  31. Medzhidova SR. The analysis of the effectiveness of the combined physiotherapy treatment for posterior uveitis. Tochka zreniya. Vostok—Zapad. 2016; (3):116-119. Accessed 04.06.2021. (In Russ.). https://eyepress.ru/article.aspx?20903
  32. Cohen AE, Assang C, Patane MA, From S, Korenfeld M; Avion Study Investigators. Evaluation of dexamethasone phosphate delivered by ocular iontophoresis for treating noninfectious anterior uveitis. Ophthalmology. 2012; 119:66-73.  https://doi.org/10.1016/j.ophtha.2011.07.006
  33. O’Neil EC, Huang J, Suhler EB, Dunn JP Jr, Perez VL, Gritz DC, McWilliams K, Peskin E, Ying G-Sh, Bunya VY, Maguire MG, Kempen JH. Iontophoretic delivery of dexamethasone phosphate for noninfectious, non-necrotising anterior scleritis, dose-finding clinical trial. Br J Ophthalmol. 2018;102:1011-1013. https://doi.org/10.1136/bjophthalmol-2017-311610
  34. Medvedev IB, Medvedev NI, Bagrov SN. Lecheniye keratokonusa metodom krosslinkinga [Treatment of keratoconus by cross-linking]. M. 2010. (In Russ.).
  35. Medvedev IB, Evgrafov VYu, Dergacheva NN. Crosslinking: methodological approaches and application in ophthalmology. Ophthalmology in Russia = Oftal’mologiya. 2016;13(2):56-61. (In Russ.). https://doi.org/10.18008/1816-5095-2016-2-56-61
  36. Lombardo M, Giannini D, Lombardo G, Serrao S. Randomized controlled trial comparing transepithelial corneal cross-linking using iontophoresis with the Dresden protocol in progressive keratoconus. Ophthalmology. 2017;124: 804-812.  https://doi.org/10.1016/j.ophtha.2017.01.040
  37. Bouheraoua N, Jouve L, El Sanharawi M, Sandali O, Temstet C, Loriaut P, Basli E, Borderie V, Laroche L. Optical coherence tomography and confocal microscopy following three different protocols of corneal collagen-crosslinking in keratoconus. Invest Ophthalmol Vis Sci. 2014;55:7601-7609. https://doi.org/10.1167/iovs.14-15662
  38. Bikbova G, Bikbov M. Standard corneal collagen crosslinking versus transepithelial iontophoresis-assisted corneal crosslinking, 24 months follow-up: randomized control trial. Acta Ophthalmol. 2016;94:600-606.  https://doi.org/10.1111/aos.13032
  39. Vinciguerra P, Romano V, Rosetta P, Legrottaglie EF, Piscopo R, Fabiani C, Azzolini C, Vinciguerra R. Transepithelial iontophoresis versus standard corneal collagen cross-linking: 1-year results of a prospective clinical study. J Refract Surg. 2016;32:672-678.  https://doi.org/10.3928/1081597X-20160629-02
  40. Cantemir A, Alexa AI, Galan BG, Anton N, Ciuntu RE, Danielescu C, Chiselita D, Costin D. Iontophoretic collagen cross-linking versus epithelium-off collagen crosslinking for early stage of progressive keratoconus-3 years follow-up study. Acta Ophthalmol. 2017;95:649-655.  https://doi.org/10.1111/aos.13538
  41. Jouve L, Borderie V, Sandali O, Temstet C, Basli E, Laroche L, Bouheraoua N. Conventional and iontophoresis corneal cross-linking for keratoconus: efficacy and assessment by optical coherence tomography and confocal microscopy. Cornea. 2017;36:153-162.  https://doi.org/10.1097/ICO.0000000000001062
  42. Wirostko BM, Assang CM, Mann B, From S, Raizman M. Efficacy and safety of an iontophoresis platform to control post cataract inflammation and pain. IOVS. 2017;58:e1081.
  43. Patane MA, Cohen A, From S, Torkildsen G, Welch D, Ousler GW. Ocular iontophoresis of EGP-437 (dexamethasone phosphate) in dry eye patients: results of a randomized clinical trial. Clin Ophthalmol. 2011;5:633-643.  https://doi.org/10.2147/OPTH.S19349
  44. Horwath-Winter J, Schmut O, Haller-Schober EM, Gruber A, Rieger G. Iodide iontophoresis as a treatment for dry eye syndrome. Br J Ophthalmol. 2005;89(1):40-44.  https://doi.org/10.1136/bjo.2004.048314
  45. Santos GA, Ferreira-Nunes R, Dalmolin LF, Santos AC, Anjos JLV, Mendanha SA, Aires CP, Lopez RFV, Cunha-Filho M, Gelfuso GM, Gratieri T. Besifloxacin liposomes with positively charged additives for an improved topical ocular delivery. Scientific Rep. 2020;10:e19285. https://doi.org/10.1038/s41598-020-76381-y
  46. Souza JG, Dias K, Silva SA, De Rezende LC, Rocha EM, Emery FS, Lopez RF. Transcorneal iontophoresis of dendrimers: PAMAM corneal penetration and dexamethasone delivery. J Control Release. 2015;200:115-124.  https://doi.org/10.1016/j.jconrel.2014.12.037
  47. Eljarrat-Binstock E, Raiskup F, Frucht-Pery J, Domb AJ. Hydrogel probe for iontophoresis drug delivery to the eye. J Biomaterials Sci. Polymer Edition. 2004;15(4):397-413.  https://doi.org/10.1163/156856204323005271
  48. Frucht-Pery J, Eljarrat-Binstock E, Orucov F, Solomon A, Hamad O, Domb AJ. Charge Nanoparticles Delivery to the Eye Using Iontophoresis. Invest Ophthalmol Vis Sci. 2008;49(13):e4798.
  49. Soni PK, Saini TR. A review on recent trends and future perspectives of iontophoresis assisted ocular drug delivery. Int J Pharm Sci Res. 2020;11(6): 2547-2556. https://doi.org/10.13040/IJPSR.0975-8232.11(6).2547-56
  50. Perez VL, Wirostko B, Korenfeld M, From S, Raizman M. Ophthalmic Drug Delivery Using Iontophoresis: Recent Clinical Applications. J Ocular Pharmacol Ther. 2020;36(2):75-87.  https://doi.org/10.1089/jop.2019.0034
  51. Patane MA, Cohen AE, Sheppard JD, Nguyen QD. Ocular Iontophoresis for Drug Delivery. Retina Today. 2011;3:64-66. 
  52. Shoeibi N, Mahdizadeh M, Shafiee M. Iontophoresis in ophthalmology: A review of the literature. Rev Clin Med. 2014;1(4):183-188.  https://doi.org/10.17463/RCM.2014.04.003
  53. Chen H. Recent developments in ocular drug delivery. J Drug Target. 2015; 23:597-604.  https://doi.org/10.3109/1061186X.2015.1052073
  54. Gratieri T, Santer V, Kalia YN. Basic principles and current status of transcorneal and transscleral iontophoresis. Exp Opin Drug Deliv. 2017;14: 1091-1102. https://doi.org/10.1080/17425247.2017.1266334
  55. Eljarrat-Binstock E, Domb AJ. Iontophoresis: a noninvasive ocular drug delivery. J Control Release. 2006;110:479-489.  https://doi.org/10.1016/j.jconrel.2005.09.049
  56. Huang D, Chen YS, Rupenthal ID. Overcoming ocular drug delivery barriers through the use of physical forces. Adv Drug Deliv Rev. 2018;126:96-112.  https://doi.org/10.1016/j.addr.2017.09.008
  57. Souza JG, Dias K, Pereira TA, Bernardi DS, Lopez RF. Topical delivery of ocular therapeutics: carrier systems and physical methods. J Pharm Pharmacol. 2014;66:507-530.  https://doi.org/10.1111/jphp.12132

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.