The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Kamyshova E.S.

I.M. Sechenov First Moscow State Medical University, Ministry of Health of Russia, Moscow, Russia

Bobkova I.N.

Otdel nefrologii NII uronefrologii i reproduktivnogo zdorov'ia cheloveka Pervogo MGMU im. I.M. Sechenova Minzdrava Rossii

MicroRNAs in chronic glomerulonephritis: Promising biomarkers for diagnosis and prognosis estimation

Authors:

Kamyshova E.S., Bobkova I.N.

More about the authors

Journal: Therapeutic Archive. 2017;89(6): 89‑96

Read: 1164 times


To cite this article:

Kamyshova ES, Bobkova IN. MicroRNAs in chronic glomerulonephritis: Promising biomarkers for diagnosis and prognosis estimation. Therapeutic Archive. 2017;89(6):89‑96. (In Russ.)
https://doi.org/10.17116/terarkh201789689-96

Recommended articles:
Myokines — the cardiometabolic risk pote­ntial biomarkers. Russian Journal of Preventive Medi­cine. 2025;(7):119-126
Modern stra­tegies for early diagnosis of cardiotoxicity caused by chemotherapy. Russian Journal of Preventive Medi­cine. 2025;(11):113-120
Possibilities of inte­ractions of circular RNAS with nucleic acids and proteins. Mole­cular Gene­tics, Microbiology and Viro­logy. 2025;(4-2):28-32

References:

  1. Schena F, Serino G, Sallustio F. MicroRNAs in kidney diseases: new promising biomarkers for diagnosis and monitoring. Nephrology Dialysis Transplantation. 2013;29(4):755-763. doi:10.1093/ndt/gft223
  2. Ha M, Kim V. Regulation of microRNA biogenesis. Nature Reviews Molecular Cell Biology. 2014;15(8):509-524. doi:10.1038/nrm3838
  3. Баулина НМ, Кулакова ОГ, Фаворова ОО. МикроРНК: роль в развитии аутоиммунного воспаления. Acta Nature (русскоязычная версия). 2016;1(28):23-36.
  4. Friedländer M, Lizano E, Houben A et al. Evidence for the biogenesis of more than 1,000 novel human microRNAs. Genome Biol. 2014;15(4):R57. doi:10.1186/gb-2014-15-4-r57
  5. Weber J, Baxter D, Zhang S et al. The MicroRNA Spectrum in 12 Body Fluids. Clinical Chemistry. 2010;56(11):1733-1741. doi:10.1373/clinchem.2010.147405
  6. Beltrami C, Clayton A, Phillips A, et al. Analysis of urinary microRNAs in chronic kidney disease: Figure 1. Biochm Soc Trans. 2012;40(4):875-879. doi:10.1042/bst20120090
  7. Shi S, Yu L, Chiu C et al. Podocyte-Selective Deletion of Dicer Induces Proteinuria and Glomerulosclerosis. Journal of the American Society of Nephrology. 2008;19(11):2159-2169. doi:10.1681/asn.2008030312
  8. Harvey S, Jarad G, Cunningham J et al. Podocyte-Specific Deletion of Dicer Alters Cytoskeletal Dynamics and Causes Glomerular Disease. Journal of the American Society of Nephrology. 2008;19(11):2150-2158. doi:10.1681/asn.2008020233
  9. Ho J, Ng K, Rosen S, et al. Podocyte-Specific Loss of Functional MicroRNAs Leads to Rapid Glomerular and Tubular Injury. Journal of the American Society of Nephrology. 2008;19(11):2069-2075. doi:10.1681/asn.2008020162
  10. Patel V, Hajarnis S, Williams D, et al. MicroRNAs Regulate Renal Tubule Maturation through Modulation of Pkd1. Journal of the American Society of Nephrology. 2012;23(12):1941-1948. doi:10.1681/asn.2012030321
  11. Sun Y. Development of a micro-array to detect human and mouse microRNAs and characterization of expression in human organs. Nucleic Acids Research. 2004;32(22):e188-e188. doi:10.1093/nar/gnh186
  12. Tian Z, Greene A, Pietrusz J, et al. MicroRNA-target pairs in the rat kidney identified by microRNA microarray, proteomic, and bioinformatic analysis. Genome Research. 2008;18(3):404-411. doi:10.1101/gr.6587008
  13. Wyatt R, Julian B. IgA Nephropathy. New England Journal of Medicine. 2013;368(25):2402-2414. doi:10.1056/nejmra1206793
  14. Novak J, Renfrow M, Gharavi A, Julian B. Pathogenesis of immunoglobulin A nephropathy. Current Opinion in Nephrology and Hypertension. 2013;22(3):287-294. doi:10.1097/mnh.0b013e32835fef54
  15. Kokubo T, Hiki Y, Iwase H, et al. Protective role of IgA1 glycans against IgA1 self-aggregation and adhesion to extracellular matrix proteins. Journal of the American Society of Nephrology. 1998;9(11):2048-2054.
  16. Kudo T, Iwai T, Kubota T et al. Molecular Cloning and Characterization of a Novel UDP-Gal:GalNAc Peptide 1,3-Galactosyltransferase (C1Gal-T2), an Enzyme Synthesizing a Core 1 Structure of O-Glycan. Journal of Biological Chemistry. 2002; 277(49):47724-47731. doi:10.1074/jbc.m205839200
  17. Iwasaki H, Zhang Y, Tachibana K et al. Initiation of O-Glycan Synthesis in IgA1 Hinge Region Is Determined by a Single Enzyme, UDP-N-Acetyl- -D-galactosamine:PolypeptideN-Acetylgalactosaminyltransferase 2. Journal of Biological Chemistry. 2002;278(8):5613-5621. doi:10.1074/jbc.m211097200
  18. Serino G, Sallustio F, Cox S, Pesce F, Schena F. Abnormal miR-148b Expression Promotes Aberrant Glycosylation of IgA1 in IgA Nephropathy. Journal of the American Society of Nephrology. 2012;23(5):814-824. doi:10.1681/asn.2011060567
  19. Serino G, Sallustio F, Curci C et al. Role of let-7b in the regulation ofN-acetylgalactosaminyltransferase 2 in IgA nephropathy. Nephrology Dialysis Transplantation. 2015;30(7):1132-1139. doi:10.1093/ndt/gfv032
  20. Schena FP, Serino G, Sallustio F, et al. A combined miRNA biomarker for non-invasive diagnosis of idiopathic IgA nephropathy: an international multicentre study (NIDIGAN study). Nephrology Dialysis Transplantation. 2014;29:iii42-iii44.
  21. Hu S, Bao H, Xu X et al. Increased miR-374b promotes cell proliferation and the production of aberrant glycosylated IgA1 in B cells of IgA nephropathy. FEBS Letters. 2015;589(24PartB):4019-4025. doi:10.1016/j.febslet.2015.10.033
  22. Liu Y. New Insights into Epithelial-Mesenchymal Transition in Kidney Fibrosis. Journal of the American Society of Nephrology. 2009;21(2):212-222. doi:10.1681/asn.2008121226
  23. Li Y, Kang Y, Dai C, et al. Epithelial-to-Mesenchymal Transition Is a Potential Pathway Leading to Podocyte Dysfunction and Proteinuria. The American Journal of Pathology. 2008;172(2):299-308. doi:10.2353/ajpath.2008.070057
  24. Gregory P, Bracken C, Bert A, Goodall G. MicroRNAs as regulators of epithelial-mesenchymal transition. Cell Cycle. 2008;7(20):3112-3117. doi:10.4161/cc.7.20.6851
  25. Wang G, Kwan B, Lai F et al. Intrarenal expression of microRNAs in patients with IgA nephropathy. Laboratory Investigation. 2009;90(1):98-103. doi:10.1038/labinvest.2009.118
  26. Kato M, Zhang J, Wang M et al. MicroRNA-192 in diabetic kidney glomeruli and its function in TGF-beta-induced collagen expression via inhibition of E-box repressors. Proceedings of the National Academy of Sciences. 2007;104(9):3432-3437. doi:10.1073/pnas.0611192104
  27. Wang G, Kwan B, Lai F, Chow K, Li P, Szeto C. Elevated Levels of miR-146a and miR-155 in Kidney Biopsy and Urine from Patients with IgA Nephropathy. Disease Markers. 2011;30(4):171-179. doi:10.1155/2011/304852
  28. Hou J, Wang P, Lin L et al. MicroRNA-146a Feedback Inhibits RIG-I-Dependent Type I IFN Production in Macrophages by Targeting TRAF6, IRAK1, and IRAK2. The Journal of Immunology. 2009;183(3):2150-2158. doi:10.4049/jimmunol.0900707
  29. Ceppi M, Pereira P, Dunand-Sauthier I et al. MicroRNA-155 modulates the interleukin-1 signaling pathway in activated human monocyte-derived dendritic cells. Proceedings of the National Academy of Sciences. 2009;106(8):2735-2740. doi:10.1073/pnas.0811073106
  30. Zheng Y, Josefowicz S, Kas A, Chu T, Gavin M, Rudensky A. Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells. Nature. 2007;445(7130):936-940. doi:10.1038/nature05563
  31. Kohlhaas S, Garden O, Scudamore C, Turner M, Okkenhaug K, Vigorito E. Cutting Edge: The Foxp3 Target miR-155 Contributes to the Development of Regulatory T Cells. The Journal of Immunology. 2009;182(5):2578-2582. doi:10.4049/jimmunol.0803162
  32. Huang H, Peng Y, Liu F, Lei H. Is IgA nephropathy induced by abnormalities of CD4+CD25+Treg cells in the tonsils? Medical Hypotheses. 2007;69(2):410-413. doi:10.1016/j.mehy.2006.11.050
  33. Wang B, Komers R, Carew R et al. Suppression of microRNA-29 Expression by TGF-1 Promotes Collagen Expression and Renal Fibrosis. Journal of the American Society of Nephrology. 2011;23(2):252-265. doi:10.1681/asn.2011010055
  34. Fang Y, Yu X, Liu Y et al. miR-29c is downregulated in renal interstitial fibrosis in humans and rats and restored by HIF-activation. AJP: Renal Physiology. 2013;304(10):F1274-F1282. doi:10.1152/ajprenal.00287.2012
  35. Xing L-N, Wang H, Yin P-H, et al. Reduced mir-29b-3p expression up-regulate CDK6 and contributes to IgA nephropathy. International Journal of Clinical and Experimental Medicine. 2014;7(12):5275-5281.
  36. Buss H, Handschick K, Jurrmann N et al. Cyclin-Dependent Kinase 6 Phosphorylates NF-κB P65 at Serine 536 and Contributes to the Regulation of Inflammatory Gene Expression. PLoS ONE. 2012;7(12):e51847. doi:10.1371/journal.pone.0051847
  37. Hennessy E, Sheedy F, Santamaria D, Barbacid M, O’Neill L. Toll-like Receptor-4 (TLR4) Down-regulates MicroRNA-107, Increasing Macrophage Adhesion via Cyclin-dependent Kinase 6. Journal of Biological Chemistry. 2011;286(29):25531-25539. doi:10.1074/jbc.m111.256206
  38. Bao H, Hu S, Zhang C et al. Inhibition of miRNA-21 prevents fibrogenic activation in podocytes and tubular cells in IgA nephropathy. Biochemical and Biophysical Research Communications. 2014;444(4):455-460. doi:10.1016/j.bbrc.2014.01.065
  39. Bao H, Chen H, Zhu X et al. MiR-223 downregulation promotes glomerular endothelial cell activation by upregulating importin α4 and α5 in IgA nephropathy. Kidney International. 2014;85(3):624-635. doi:10.1038/ki.2013.469
  40. Fagerlund R, Kinnunen L, Kohler M, Julkunen I, Melen K. NF-κB Is Transported into the Nucleus by Importin α3 and Importin α4. Journal of Biological Chemistry. 2005;280(16):15942-15951. doi:10.1074/jbc.m500814200
  41. Ma J, Cao X. Regulation of Stat3 nuclear import by importin α5 and importin α7 via two different functional sequence elements. Cellular Signalling. 2006;18(8):1117-1126. doi:10.1016/j.cellsig.2005.06.016
  42. Mall C, Rocke D, Durbin-Johnson B, Weiss R. Stability of miRNA in human urine supports its biomarker potential. Biomarkers in Medicine. 2013;7(4):623-631. doi:10.2217/bmm.13.44
  43. Wang G, Kwan B, Lai F, Chow K, Li P, Szeto C. Urinary miR-21, miR-29, and miR-93: Novel Biomarkers of Fibrosis. American Journal of Nephrology. 2012;36(5):412-418. doi:10.1159/000343452
  44. Tan K, Chen J, Li W et al. Genome-wide analysis of microRNAs expression profiling in patients with primary IgA nephropathy. Genome. 2013;56(3):161-169. doi:10.1139/gen-2012-0159
  45. Dai Y, Sui W, Lan H, Yan Q, Huang H, Huang Y. Comprehensive analysis of microRNA expression patterns in renal biopsies of lupus nephritis patients. Rheumatology International. 2008;29(7):749-754. doi:10.1007/s00296-008-0758-6
  46. Cai X, Xia Z, Zhang C et al. Serum microRNAs levels in primary focal segmental glomerulosclerosis. Pediatric Nephrology. 2013;28(9):1797-1801. doi:10.1007/s00467-013-2434-7
  47. Zhang C, Zhang W, Chen H et al. Plasma MicroRNA-186 and Proteinuria in Focal Segmental Glomerulosclerosis. American Journal of Kidney Diseases. 2015;65(2):223-232. doi:10.1053/j.ajkd.2014.07.013
  48. Zhang W, Zhang C, Chen H et al. Evaluation of MicroRNAs miR-196a, miR-30a-5P, and miR-490 as Biomarkers of Disease Activity among Patients with FSGS. Clinical Journal of the American Society of Nephrology. 2014;9(9):1545-1552. doi:10.2215/cjn.11561113
  49. Wu J, Zheng C, Fan Y et al. Downregulation of MicroRNA-30 Facilitates Podocyte Injury and Is Prevented by Glucocorticoids. Journal of the American Society of Nephrology. 2013;25(1):92-104. doi:10.1681/asn.2012111101
  50. Wang N, Zhou Y, Jiang L et al. Urinary MicroRNA-10a and MicroRNA-30d Serve as Novel, Sensitive and Specific Biomarkers for Kidney Injury. PLoS ONE. 2012;7(12):e51140. doi:10.1371/journal.pone.0051140
  51. Gebeshuber C, Kornauth C, Dong L et al. Focal segmental glomerulosclerosis is induced by microRNA-193a and its downregulation of WT1. Nature Medicine. 2013;19(4):481-487. doi:10.1038/nm.3142
  52. Morrison A, Viney R, Saleem M, Ladomery M. New insights into the function of the Wilms tumor suppressor gene WT1 in podocytes. AJP: Renal Physiology. 2008;295(1):F12-F17. doi:10.1152/ajprenal.00597.2007
  53. Kietzmann L, Guhr S, Meyer T et al. MicroRNA-193a Regulates the Transdifferentiation of Human Parietal Epithelial Cells toward a Podocyte Phenotype. Journal of the American Society of Nephrology. 2014;26(6):1389-1401. doi:10.1681/asn.2014020190
  54. Chen W, Lin X, Huang J et al. Integrated profiling of microRNA expression in membranous nephropathy using high-throughput sequencing technology. International Journal of Molecular Medicine. 2013;33:25-34. doi:10.3892/ijmm.2013.1554
  55. Smirnov A, Karunnaya А, Zarayski М et al. Urinary microRNA-21 expression in nephropathies. Nephrology. 2014;18(6):59-63. (In Russ.)

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.