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Ionova Z.I.

Pavlov First Saint Petersburg State Medical University

Berkovich O.A.

Pavlov First Saint Petersburg State Medical University

Belyaeva O.D.

Pavlov First Saint Petersburg State Medical University

Zaraisky M.I.

Mechnikov North-Western State Medical University

Kolodina D.A.

Pavlov First Saint Petersburg State Medical University

Serum expression of microRNA-21, microRNA-125a, microRNA-125b, microRNA-214 in coronary artery disease patients

Authors:

Ionova Z.I., Berkovich O.A., Belyaeva O.D., Zaraisky M.I., Kolodina D.A.

More about the authors

Journal: Russian Cardiology Bulletin. 2025;20(2): 13‑19

DOI: 10.17116/Cardiobulletin20252002113

Read: 781 times

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Table of contents

SERUM EXPRESSION OF MICRORNA-21, MICRORNA-125A, MICRORNA-125B, MICRORNA-214 IN CORONARY ARTERY DISEASE PATIENTS
SERUM EXPRESSION OF MICRORNA-21, MICRORNA-125A, MICRORNA-125B, MICRORNA-214 IN CORONARY ARTERY DISEASE PATIENTS

To cite this article:

Ionova ZI, Berkovich OA, Belyaeva OD, Zaraisky MI, Kolodina DA. Serum expression of microRNA-21, microRNA-125a, microRNA-125b, microRNA-214 in coronary artery disease patients. Russian Cardiology Bulletin. 2025;20(2):13‑19. (In Russ.)
https://doi.org/10.17116/Cardiobulletin20252002113

ЭндоКард
Подписка 2026 Кардиологический вестник (Russian Cardiology Bulletin)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

BACKGROUND

Coronary artery disease (CAD) is determined by interaction of environmental factors with epigenetic and genetic factors. MicroRNA-21, microRNA-125a, microRNA-125b and microRNA-214 are small non-coding RNAs and the most important regulators of gene expression. MicroRNA-21, -125a, -125b and -214 are insufficiently studied in CAD patients.

OBJECTIVE

To explore serum expression of microRNA-21, microRNA-125a, microRNA-125b, microRNA-214 in CAD patients with different features of clinical course.

MATERIAL AND METHODS

The study included 129 CAD patients (men 56.6% and women 43.4%) aged 63.17±8.57 years. The comparison group consisted of 45 people without CAD (men 55.6% and women 44.4%) aged 62.09±8.79 years (p>0.05). Serum microRNA expression was analyzed using real-time polymerase chain reaction. Relative microRNA expression was estimated in accordance with standard 2-ΔCt procedure.

RESULTS

Serum expression of microRNA-21, microRNA-125a, microRNA-125b and microRNA-214 is higher in CAD patients (p<0.001). MicroRNA-21 expression >16.43 units increases the risk of CAD by 3.49 times (HR 3.49, 95% CI 1.70—7.17, p<0.001), microRNA-125a expression >7.21 units — by 5.18 times (HR 5.18, 95% CI 2.29—11.69, p<0.001), microRNA-125b expression >3.49 units — by 4.03 times (HR 4.03, 95% CI 1.86—8.72, p=0.0001), microRNA-214 expression >2.47 units — by 3.99 times (HR 3.99, 95% CI 1.91—8.37, p<0.001). Expression of microRNA-21 and microRNA-214 was higher in patients with early CAD than in older patients (p<0.05). Expression of microRNA-21, microRNA-125a, microRNA-125b and microRNA-214 was higher in CAD patients with myocardial infarction (MI) than in patients without MI (p<0.05).

CONCLUSION

Expression of microRNA-21, microRNA-125a, microRNA-125b and microRNA-214 was higher in CAD patients than in the comparison group, as well as in CAD patients with MI. Expression of microRNA-21 and microRNA-214 was higher in patients with early CAD than in older patients.

Keywords:

coronary artery disease
myocardial infarction
microRNA

Authors:

Ionova Z.I.

Pavlov First Saint Petersburg State Medical University

Berkovich O.A.

Pavlov First Saint Petersburg State Medical University

Belyaeva O.D.

Pavlov First Saint Petersburg State Medical University

Zaraisky M.I.

Mechnikov North-Western State Medical University

Kolodina D.A.

Pavlov First Saint Petersburg State Medical University

Received:

18.09.2024

Accepted:

07.11.2024

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