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Garbuzenko D.V.

Kafedra fakul'tetskoĭ khirurgii Cheliabinskoĭ gosudarstvennoĭ meditsinskoĭ akademii

Aspects of pathogenetic pharmacotherapy for portal hypertension in liver cirrhosis

Authors:

Garbuzenko D.V.

More about the authors

Journal: Therapeutic Archive. 2016;88(2): 101‑108

DOI: 10.17116/terarkh2016888101-108

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Table of contents

ASPECTS OF PATHOGENETIC PHARMACOTHERAPY FOR PORTAL HYPERTENSION IN LIVER CIRRHOSIS
ASPECTS OF PATHOGENETIC PHARMACOTHERAPY FOR PORTAL HYPERTENSION IN LIVER CIRRHOSIS

To cite this article:

Garbuzenko DV. Aspects of pathogenetic pharmacotherapy for portal hypertension in liver cirrhosis. Therapeutic Archive. 2016;88(2):101‑108. (In Russ.)
https://doi.org/10.17116/terarkh2016888101-108

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The review of literature considers the principles of medical treatment for portal hypertension in liver cirrhosis, which are based on the current views of its development mechanisms. It describes both current pharmacotherapy methods for portal hypertension and drugs, the efficacy of which is being investigated.

Keywords:

liver cirrhosis
portal hypertension
pathogenesis
pharmacotherapy

Authors:

Garbuzenko D.V.

Kafedra fakul'tetskoĭ khirurgii Cheliabinskoĭ gosudarstvennoĭ meditsinskoĭ akademii

List of references:

  1. Garbuzenko D.V. Morfofunktsional'naya perestroika pechenochnogo sosudistogo rusla v patogeneze portal'noi gipertenzii pri tsirroze pecheni. Terapevticheskii arkhiv. 2014; 86(2):90-95. 
  2. Garbuzenko D.V. Mekhanizmy adaptatsii sosudistogo rusla k gemodinamicheskim narusheniyam pri portal'noi gipertenzii. VestnikRAMN. 2013;1:52-57.
  3. Berzigotti A, Bosch J. Pharmacologic Management of Portal Hypertension. Clin Liver Dis. 2014;18(2):303-317.  doi:10.1016/j.cld.2013.12.003.
  4. Møller S, Hansen EF, Becker U, Brinch K, Henriksen JH, Bendtsen F. Central and systemic haemodynamic effects of terlipressin in portal hypertensive patients. Liver. 2000;20(1):51-59. 
  5. Ding C, Wu X, Fan X, He C, Li J. Hemodynamic effects of continuous versus bolus infusion of terlipressin for portal hypertension: a randomized comparison. J Gastroenterol Hepatol. 2013;28(7):1242-1246. doi:10.1111/jgh.12195.
  6. Augustin S, Gonzalez A, Genesca J. Acute esophageal variceal bleeding: Current strategies and new perspectives. World J Hepatol. 2010;2(7):261-274. 
  7. Lata J. Hepatorenal syndrome. World J Gastroenterol. 2012; 18(36):4978-4984. doi:10.3748/wjg.v18.i36.4978.
  8. Moreau R, Lebrec D. The use of vasoconstrictors in patients with cirrhosis: type 1 HRS and beyond. Hepatology. 2006;43(3):385-394. 
  9. Reynaert H, Geerts A. Pharmacological rationale for the use of somatostatin and analogues in portal hypertension. Aliment Pharmacol Ther. 2003;18(4):375-386. 
  10. Wang J, Wang L, Song G, Han B. The mechanism through which octreotide inhibits hepatic stellate cell activity. Mol Med Rep. 2013;7(5):1559-1564. doi:10.3892/mmr.2013.1385.
  11. Mejias M, Garcia-Pras E, Tiani C, Bosch J, Fernandez M. The somatostatin analogue octreotide inhibits angiogenesis in the earliest, but not in advanced, stages of portal hypertesion in rats. J Cell Mol Med. 2008;12(5A):1690-1699. doi:10.1111/j.1582-4934.2008.00218.x.
  12. Escorsell A, Bandi JC, Andreu V, Moitinho E, García-Pagán JC, Bosch J, Rodés J. Desensitization to the effects of intravenous octreotide in cirrhotic patients with portal hypertension. Gastroenterology. 2001;120(1):161-169. 
  13. Garcia-Tsao G, Bosch J. Management of varices and variceal hemorrhage in cirrhosis. N Engl J Med 2010;362(9):823-832. 
  14. de Franchis R, Baveno V Faculty. Revising consensus in portal hypertension: report of the Baveno V consensus workshop on methodology of diagnosis and therapy in portal hypertension. J Hepatol. 2010;53(4):762-768.  doi:10.1016/j.jhep.2010.06.004.
  15. Tripathi D, Hayes PC. Beta-blockers in portal hypertension: new developments and controversies. Liver Int. 2014;34(5):655-667.  doi:10.1111/liv.12360.
  16. Bosch J, Berzigotti A, Garcia-Pagan JC, Abraldes JG. The management of portal hypertension: rational basis, available treatments and future options. J Hepatol. 2008;48(Suppl 1):68-92.
  17. Ferrarese A, Tsochatzis E, Burroughs AK, Senzolo M. Beta-blockers in cirrhosis: Therapeutic window or an aspirin for all? J Hepatol. 2014;61(2):449-450.  doi:10.1016/j.jhep.2014.03.038.
  18. Ge PS, Runyon BA. The changing role of beta-blocker therapy in patients with cirrhosis. J Hepatol. 2014;60(3):643-653.  doi:10.1016/j.jhep.2013.09.016.
  19. D’Amico G. The role of vasoactive drugs in the treatment of oesophageal varices. Expert Opin Pharmacother. 2004;5(2):349-360. 
  20. Bellis L, Berzigotti A, Abraldes JG, Moitinho E, García-Pagán JC, Bosch J, Rodés J. Low doses of isosorbide mononitrate attenuate the postprandial increase in portal pressure in patients with cirrhosis. Hepatology. 2003;37(2):378-384. 
  21. Kravetz D. Prevention of recurrent esophageal variceal hemorrhage: review and current recommendations. J Clin Gastroenterol. 2007;41(Suppl 3):318-322. 
  22. Albillos A, Lledó JL, Rossi I, Pérez-Páramo M, Tabuenca MJ, Bañares R, Iborra J, Garrido A, Escartín P, Bosch J. Continuous prazosin administration in cirrhotic patients: effects on portal hemodynamics and on liver and renal function. Gastroenterology. 1995;109(4):1257-1265.
  23. Bañares R, Moitinho E, Piqueras B, Casado M, García-Pagán JC, de Diego A, Bosch J. Carvedilol, a new nonselective β-blocker with intrinsic anti-α-adrenergic activity, has greater portal hypertensive effect than propranolol in patients with cirrhosis. Hepatology. 1999;30(1):79-83.
  24. Lo G.H, Chen WC, Wang HM, Yu HC. Randomized, controlled trial of carvedilol versus nadolol plus isosorbide mononitrate for the prevention of variceal rebleeding. J Gastroenterol Hepatol. 2012;27(11):1681-1687.
  25. Sinagra E, Perricone G, D’Amico M, Tinè F, D’Amico G. Systematic review with meta-analysis: the haemodynamic effects of carvedilol compared with propranolol for portal hypertension in cirrhosis. AlimentPharmacol Ther. 2014;39(6):557-568.  doi:10.1111/apt.12634.
  26. Garbuzenko D.V., Mikurov A.A. Rol' endotoksemii v razvitii krovotechenii iz varikozno-rasshirennykh ven pishchevoda u bol'nykh tsirrozom pecheni. Rossiiskii meditsinskii zhurnal 2011;6:47-49. 
  27. Lee YY, Tee HP, Mahadeva S. Role of prophylactic antibiotics in cirrhotic patients with variceal bleeding. World J Gastroenterol. 2014;20(7):1790-1796. doi: 10.3748/wjg.v20.i7.1790
  28. Chavez-Tapia NC, Barrientos-Gutierrez T, Tellez-Avila F, Soares-Weiser K, Mendez-Sanchez N, Gluud C, Uribe M. Meta-analysis: antibiotic prophylaxis for cirrhotic patients with upper gastrointestinal bleeding — an updated Cochrane review. Aliment Pharmacol Ther. 2011;34(5):509-518.  doi:10.1111/j.1365-2036.2011.04746.x.
  29. Cohen-Naftaly M, Friedman SL. Current status of novel antifibrotic therapies in patients with chronic liver disease. Therap Adv Gastroenterol. 2011;4(6):391-417. 
  30. Copple BL, Bai S, Burgoon LD, Moon JO. Hypoxia-inducible factor-1α regulates the expression of genes in hypoxic hepatic stellate cells important for collagen deposition and angiogenesis. Liver Int. 2011;31(2):230-244. 
  31. Pozzi M, Pizzala DP, Maldini FF, Doretti A, Ratti L. Portal pressure reduction after entecavir treatment in compensated HBV cirrhosis. Hepatogastroenterology. 2009;56(89):231-235. 
  32. Colmenero J, Bataller R, Sancho-Bru P, Domínguez M, Moreno M, Forns X, Bruguera M, Arroyo V, Brenner DA, Ginès P. Effects of losartan on hepatic expression of nonphagocytic NADPH oxidase and fibrogenic genes in patients with chronic hepatitis C. Am J Physiol GastrointestLiver Physiol. 2009;297(4):726-734.  doi:10.1152/ajpgi.00162.2009.
  33. Tandon P, Abraldes JG, Berzigotti A, Garcia-Pagan JC, Bosch J. Renin-angiotensin-aldosterone inhibitors in the reduction of portal pressure: a systematic review and meta-analysis. J Hepatol. 2010;53(2):273-282.  doi:10.1016/j.jhep.2010.03.013.
  34. Agasti AK, Mahajan AU, Phadke AY, Nathani PJ, Sawant P. Comparative randomized study on efficacy of losartan versus propranolol in lowering portal pressure in decompensated chronic liver disease. J Dig Dis. 2013;14(5):266-271.  doi:10.1111/1751-2980.12025.
  35. Hu LS, George J, Wang JH. Current concepts on the role of nitric oxide in portal hypertension. World J Gastroenterol. 2013;19(11):1707-1717. doi:10.3748/wjg.v19.i11.1707.
  36. La Mura V, Pasarín M, Meireles CZ, Miquel R, Rodríguez-Vilarrupla A, Hide D, Gracia-Sancho J, García-Pagán JC, Bosch J, Abraldes JG. Effects of simvastatin administration on rodents with lipopolysaccharide-induced liver microvascular dysfunction. Hepatology. 2013;57(3):1172-1181. doi:10.1002/hep.26127.
  37. Trebicka J, Hennenberg M, Laleman W, Shelest N, Biecker E, Schepke M, Nevens F, Sauerbruch T, Heller J. Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of RhoA/Rho-kinase and activation of endothelial nitric oxide synthase. Hepatology. 2007;46(1):242-253. 
  38. Hsu SJ, Wang SS, Hsin IF, Huang HC, Lee FY, Lee JY, Lin HC, Chuang CL, Lee SD. Effects of simvastatin on the portal-systemic collateral vascular response to endothelin-1 and shunting degree in portal hypertensive rats. Scand J Gastroenterol. 2013;48(7):831-838.  doi:10.3109/00365521.2012.711851.
  39. Abraldes JG, Albillos A, Bañares R, Turnes J, González R, García-Pagán JC, Bosch J. Simvastatin lowers portal pressure in patients with cirrhosis and portal hypertension: a randomized controlled trial. Gastroenterology. 2009;136(5):1651-1658. doi:10.1053/j.gastro.2009.01.043.
  40. Lee KC, Yang YY, Huang YT, Lee FY, Hou MC, Lin HC, Lee SD. Administration of a low dose of sildenafil for 1 week decreases intrahepatic resistance in rats with biliary cirrhosis: the role of NO bioavailability. Clin Sci. 2010;119(1):45-55.  doi:10.1042/cs20090601.
  41. Kalambokis GN, Kosta P, Pappas K, Tsianos EV. Haemodynamic and renal effects of tadalafil in patients with cirrhosis. World J Gastroenterol.
  42. 2010;16(39):5009-5010.
  43. Fiorucci S, Antonelli E, Morelli A. Nitric oxide and portal hypertension: a nitric oxide-releasing derivative of ursodeoxycholic acid that selectively releases nitric oxide in the liver. Dig Liver Dis. 2003;35(Suppl 2):61-69. 
  44. Berzigotti A, Bellot P, De Gottardi A, Garcia-Pagan JC, Gagnon C, Spénard J, Bosch J. NCX-1000, a nitric oxide-releasing derivative of UDCA, does not decrease portal pressure in patients with cirrhosis: results of a randomized, double-blind, dose-escalating study. Am J Gastroenterol. 2010;105(5):1094-1101. doi:10.1038/ajg.2009.661.
  45. Fukuda T, Narahara Y, Kanazawa H, Matsushita Y, Kidokoro H, Itokawa N, Kondo C, Atsukawa M, Nakatsuka K, Sakamoto C. Effects of fasudil on the portal and systemic hemodynamics of patients with cirrhosis. J Gastroenterol Hepatol. 2014;29(2):325-329.  doi:10.1111/jgh.12360.
  46. Cavasin MA, Semus H, Pitts K, Peng Y, Sandoval J, Chapo J, Plato CF. Acute effects of endothelin receptor antagonists on hepatic hemodynamics of cirrhotic and noncirrhotic rats. Can J Physiol Pharmacol. 2010;88(6):636-643.  doi:10.1139/y10-038.
  47. Lebrec D, Bosch J, Jalan R, Dudley FJ, Jessic R, Moreau R, Garcia-Pagan JC, Mookerjee RP, Chiossi E, Van Giersbergen PL, Kusic-Pajic A, Dingemanse J. Hemodynamics and pharmacokinetics of tezosentan, a dual endothelin receptor antagonist, in patients with cirrhosis. Eur J ClinPharmacol. 2012;68(5):533-541.  doi:10.1007/s00228-011-1157-6.
  48. Angermayr B, Fernandez M, Mejias M, Gracia-Sancho J, Garcia-Pagan JC, Bosch J. NAD(P)H oxidase modulates angiogenesis and the development of portosystemic collaterals and splanchnic hyperaemia in portal hypertensive rats. Gut. 2007;56(4):560-564. 
  49. Mejias M, Garcia-Pras E, Tiani C, Miquel R, Bosch J, Fernandez M. Beneficial effects of sorafenib on splanchnic, intrahepatic, and portocollateral circulations in portal hypertensive and cirrhotic rats. Hepatology. 2009;49(4):1245-1256. doi:10.1002/hep.22758.
  50. D’Amico M., Mejias M., Garcia-Pras E. et al. Effects of the combined administration of propranolol plus sorafenib on portal hypertension in cirrhotic rats. Am J Physiol Gastrointest Liver Physiol. 2012;302(10):1191-1198.
  51. Pinter M, Sieghart W, Reiberger T, Rohr-Udilova N, Ferlitsch A, Peck-Radosavljevic M. The effects of sorafenib on the portal hypertensive syndrome in patients with liver cirrhosis and hepatocellular carcinoma — a pilot study. Aliment Pharmacol Ther. 2012;35(1):83-91.  doi:10.1111/j.1365-2036.2011.04896.x.
  52. Hernández-Guerra M, García-Pagán JC, Turnes J, Bellot P, Deulofeu R, Abraldes JG, Bosch J. Ascorbic acid improves the intrahepatic endothelial dysfunction of patients with cirrhosis and portal hypertension. Hepatology. 2006;43(3):485-491.
  53. De Gottardi A, Berzigotti A, Seijo S, D’Amico M, Thormann W, Abraldes JG, García-Pagán JC, Bosch J. Postprandial effects of dark chocolate on portal hypertension in patients with cirrhosis: results of a phase 2, double-blind, randomized controlled trial. Am J Clin Nutr. 2012;96(3):584-590.  doi:10.3945/ajcn.112.040469.
  54. Hsu SJ, Wang SS, Hsin IF, Lee FY, Huang HC, Huo TI, Lee WS, Lin HC, Lee SD. Green tea polyphenol decreases the severity of portosystemic collaterals and mesenteric angiogenesis in rats with liver cirrhosis. Clin Sci (Lond). 2014;126(9):633-644.  doi:10.1042/cs20130215.
  55. Arvaniti V, D’Amico G, Fede G, Manousou P, Tsochatzis E, Pleguezuelo M, Burroughs AK. Infections in patients with cirrhosis increase mortality four-fold and should be used in determining prognosis. Gastroenterology. 2010;139(4):1246-1256. doi:10.1053/j.gastro.2010.06.019.
  56. Schwabe RF, Seki E, Brenner DA. Toll-like receptor signaling in the liver. Gastroenterology. 2006;130(6):1886-1900.
  57. Thabut D, Tazi KA, Bonnefont-Rousselot D, Aller M, Farges O, Guimont MC, Tellier Z, Guichard C, Ogier-Denis E, Poynard T, Moreau R, Lebrec D. High-density lipoprotein administration attenuates liver proinflammatory response, restores liver endothelial nitric oxide synthase activity, and lowers portal pressure in cirrhotic rats. Hepatology. 2007;46(6):1893-1906.
  58. Bellot P, García-Pagán JC, Francés R, Abraldes JG, Navasa M, Pérez-Mateo M, Such J, Bosch J. Bacterial DNA translocation is associated with systemic circulatory abnormalities and intrahepatic endothelial dysfunction in patients with cirrhosis. Hepatology. 2010;52(6):2044-2052. doi:10.1002/hep.23918.
  59. Garbuzenko D.V., Mikurov A.A., Smirnov D.M. Bakterial'naya endotoksinemiya i risk razvitiya krovotechenii iz varikozno-rasshirennykh ven pishchevoda u bol'nykh tsirrozom pecheni. Klinicheskayameditsina 2012;7:48-51. 
  60. Rasaratnam B, Kaye D, Jennings G, Dudley F, Chin-Dusting J. The effect of selective intestinal decontamination on the hyperdynamic circulatory state in cirrhosis. A randomized trial. Ann Intern Med. 2003;139(3):186-193. 
  61. Fernández J, Navasa M, Planas R, Montoliu S, Monfort D, Soriano G, Vila C, Pardo A, Quintero E, Vargas V, Such J, Ginès P, Arroyo V. Primary prophylaxis of spontaneous bacterial peritonitis delays hepatorenal syndrome and improves survival in cirrhosis. Gastroenterology. 2007;133(3):818-824.
  62. Vlachogiannakos J, Saveriadis AS, Viazis N, Theodoropoulos I, Foudoulis K, Manolakopoulos S, Raptis S, Karamanolis DG. Intestinal decontamination improves liver haemodynamics in patients with alcohol-related decompensated cirrhosis. Aliment Pharmacol Ther. 2009;29(9):992-999.  doi:10.1111/j.1365-2036.2009.03958.x.
  63. Vlachogiannakos J, Viazis N, Vasianopoulou P, Vafiadis I, Karamanolis DG, Ladas SD. Long-term administration of rifaximin improves the prognosis of patients with decompensated alcoholic cirrhosis. J GastroenterolHepatol. 2013;28(3):450-455.  doi:10.1111/jgh.12070.
  64. Zhu Q, Zou L, Jagavelu K, Simonetto DA, Huebert RC, Jiang ZD, DuPont HL, Shah VH. Intestinal decontamination inhibits TLR4 dependent fibronectin-mediated cross-talk between stellate cells and endothelial cells in liver fibrosis in mice. J Hepatol. 2012;56(4):893-899.  doi:10.1016/j.jhep.2011.11.013.
  65. Rashid SK, Khodja NI, Auger C, Alhosin M, Boehm N, Oswald-Mammosser M, Schini-Kerth VB. Probiotics (VSL#3) prevent endothelial dysfunction in rats with portal hypertension: role of the angiotensin system. PLoS One. 2014;9(5):e97458. doi:10.1371/journal.pone.0097458. ecollection 2014.
  66. Tandon P, Moncrief K, Madsen K, Arrieta MC, Owen RJ, Bain VG, Wong WW, Ma MM. Effects of probiotic therapy on portal pressure in patients with cirrhosis: a pilot study. Liver Int. 2009;29(7):1110-1115. doi:10.1111/j.1478-3231.2009.02020.x.
  67. Jayakumar S, Carbonneau M, Hotte N, Befus AD, St Laurent C, Owen R, McCarthy M, Madsen K, Bailey RJ, Ma M, Bain V, Rioux K, Tandon P. VSL#3 probiotic therapy does not reduce portal pressures in patients with decompensated cirrhosis. Liver Int. 2013;33(10):1470-1477. doi:10.1111/liv.12280.
  68. Gupta N, Kumar A, Sharma P, Garg V, Sharma BC, Sarin SK. Effects of the adjunctive probiotic VSL#3 on portal haemodynamics in patients with cirrhosis and large varices: a randomized trial. Liver Int. 2013;33(8):1148-1157. doi:10.1111/liv.12172.
  69. Zhao X, Deng B, Xu XY, Yang SJ, Zhang T, Song YJ, Liu XT, Wang YQ, Cai DY. Glycyrrhizinate reduces portal hypertension in isolated perfused rat livers with chronic hepatitis. World J Gastroenterol. 2013;19(36):6069-6076. doi:10.3748/wjg.v19.i36.6069.
  70. Di Pascoli M, Diví M, Rodríguez-Vilarrupla A, Rosado E, Gracia-Sancho J, Vilaseca M, Bosch J, García-Pagán JC. Resveratrol improves intrahepatic endothelial dysfunction and reduces hepatic fibrosis and portal pressure in cirrhotic rats. J Hepatol. 2013;58(5):904-910.  doi:10.1016/j.jhep.2012.12.012.
  71. Yang YY, Huang YT, Lee KC, Lee FY, Lee TY, Hou MC, Lin HC, Lee SD. Chronic administration of ursodeoxycholic acid decreases portal pressure in rats with b iliary cirrhosis. Clin Sci (Lond). 2009;116(1):71-79.  doi:10.1042/cs20080075.
  72. Rodríguez-Vilarrupla A, Laviña B, García-Calderó H, Russo L, Rosado E, Roglans N, Bosch J, García-Pagán JC. PPARα activation improves endothelial dysfunction and reduces fibrosis and portal pressure in cirrhotic rats. J Hepatol. 2012;56(5):1033-1039. doi:10.1016/j.jhep.2011.12.008.
  73. Hsieh YC, Chan CC, Lee KC, Huang YT, Lee FY, Yang YY, Lin HC. Aliskiren reduces portal pressure and intrahepatic resistance in biliary cirrhotic rats. J Chin Med Assoc. 2012;75(10):501-508.  doi:10.1016/j.jcma.2012.07.001.
  74. Luo W, Meng Y, Ji HL, Pan CQ, Huang S, Yu CH, Xiao LM, Cui K, Ni SY, Zhang ZS, Li X. Spironolactone Lowers Portal Hypertension by Inhibiting Liver Fibrosis, ROCK-2 Activity and Activating NO/PKG Pathway in the Bile-Duct-Ligated Rat. PLoS One. 2012;7(3):e34230. doi:10.1371/journal.pone.0034230.
  75. Gao JH, Wen SL, Yang WJ, Lu YY, Tong H, Huang ZY, Liu ZX, Tang CW. Celecoxib ameliorates portal hypertension of the cirrhotic rats through the dual inhibitory effects on the intrahepatic fibrosis and angiogenesis. PLoS One. 2013;8(7):e69309. doi:10.1371/journal.pone.0069309.
  76. Rosado E, Rodríguez-Vilarrupla A, Gracia-Sancho J, Tripathi D, García-Calderó H, Bosch J, García-Pagán JC. Terutroban, a TP-receptor antagonist, reduces portal pressure in cirrhotic rats. Hepatology. 2013;58(4):1424-1435. doi:10.1002/hep.26520.
  77. Wang W, Yan J, Wang H, Shi M, Zhang M, Yang W, Peng C, Li H. Rapamycin ameliorates inflammation and fibrosis in the early phase of cirrhotic portal hypertension in rats through inhibition of mTORC1 but not mTORC2. PLoS One. 2014;9(1):e83908. doi:10.1371/journal.pone.0083908. ecollection 2014.
  78. Laleman W, Van Landeghem L, Van der Elst I, Zeegers M, Fevery J, Nevens F. Nitroflurbiprofen, a nitric oxide-releasing cyclooxygenase inhibitor, improves cirrhotic portal hypertension in rats. Gastroenterology. 2007;132(2):709-719. 
  79. Yang YY, Lee TY, Huang YT, Chan CC, Yeh YC, Lee FY, Lee SD, Lin HC. Asymmetric dimethylarginine (ADMA) determines the improvement of hepatic endothelial dysfunction by vitamin E in cirrhotic rats. Liver Int. 2012;32(1):48-57.  doi:10.1111/j.1478-3231.2011.02651.x.
  80. Liu Z, van Grunsven LA, Van Rossen E, Schroyen B, Timmermans JP, Geerts A, Reynaert H. Blebbistatin inhibits contraction and accelerates migration in mouse hepatic stellate cells. Br J Pharmacol. 2010;159(2):304-315.  doi:10.1111/j.1476-5381.2009.00477.x.
  81. Verbeke L, Farre R, Trebicka J, Komuta M, Roskams T, Klein S, Elst IV, Windmolders P, Vanuytsel T, Nevens F, Laleman W. Obeticholic acid, a farnesoid X receptor agonist, improves portal hypertension by two distinct pathways in cirrhotic rats. Hepatology. 2014;59(6):2286-2298. doi:10.1002/hep.26939.
  82. Steib CJ, Bilzer M, op den Winkel M, Pfeiler S, Hartmann AC, Hennenberg M, Göke B, Gerbes AL. Treatment with the leukotriene inhibitor montelukast for 10 days attenuates portal hypertension in rat liver cirrhosis. Hepatology. 2010;51(6):2086-2096. doi:10.1002/hep.23596.
  83. Xu H, Zhou Y, Lu C, Ping J, Xu LM. Salvianolic acid B lowers portal pressure in cirrhotic rats and attenuates contraction of rat hepatic stellate cells by inhibiting RhoA signaling pathway. Lab Invest. 2012;92(12):1738-1748. doi:10.1038/labinvest.2012.113.
  84. Fallowfield JA, Hayden AL, Snowdon VK, Aucott RL, Stutchfield BM, Mole DJ, Pellicoro A, Gordon-Walker TT, Henke A, Schrader J, Trivedi PJ, Princivalle M, Forbes SJ, Collins JE, Iredale JP. Relaxin modulates human and rat hepatic myofibroblast function and ameliorates portal hypertension in vivo. Hepatology. 2014;59(4):1492-1504. doi:10.1002/hep.26627.
  85. Fernandez M, Mejias M, Garcia-Pras E, Mendez R, Garcia-Pagan JC, Bosch J. Reversal of portal hypertension and hyperdynamic splanchnic circulation by combined vascular endothelial growth factor and platelet-derived growth factor blockade in rats. Hepatology. 2007;46(4):1208-1217.
  86. Schwabl P, Payer BA, Grahovac J, Klein S, Horvatits T, Mitterhauser M, Stift J, Boucher Y, Trebicka J, Trauner M, Angermayr B, Fuhrmann V, Reiberger T, Peck-Radosavljevic M. Pioglitazone decreases portosystemic shunting by modulating inflammation and angiogenesis in cirrhotic and non-cirrhotic portal hypertensive rats. J Hepatol. 2014;60(6):1135-1142. doi:10.1016/j.jhep.2014.01.025.
  87. Lin HC, Huang YT, Yang YY, Lee PC, Hwang LH, Lee WP, Kuo YJ, Lee KC, Hsieh YC, Liu RS. Beneficial effects of dual vascular endothelial growth factor receptor/fibroblast growth factor receptor inhibitor brivanib alaninate in cirrhotic portal hypertensive rats. J GastroenterolHepatol. 2014;29(5):1073-1082. doi:10.1111/jgh.12480.

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