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Voskanyan S.E.

Burnasyan Federal Biophysical Center

Sushkov A.I.

Burnasyan Federal Biophysical Center

Artemiev A.I.

Burnasyan Federal Biophysical Center

Rudakov V.S.

Burnasyan Federal Biophysical Center

Kolyshev I.Yu.

Burnasyan Federal Biophysical Center

Gubarev K.K.

Burnazyan Federal Medical Biophysical Center of Federal Medical Biological Agency

Zabezhinskiy D.A.

Burnasyan Federal Biophysical Center

Popov M.V.

Burnasyan Federal Biophysical Center

Liver transplantation program at the Burnasyan Federal Biophysical Center: experience in 500 procedures

Authors:

Voskanyan S.E., Sushkov A.I., Artemiev A.I., Rudakov V.S., Kolyshev I.Yu., Gubarev K.K., Zabezhinskiy D.A., Popov M.V.

More about the authors

Journal: Pirogov Russian Journal of Surgery. 2024;(7): 45‑60

DOI: 10.17116/hirurgia202407145

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To cite this article:

Voskanyan SE, Sushkov AI, Artemiev AI, et al. . Liver transplantation program at the Burnasyan Federal Biophysical Center: experience in 500 procedures. Pirogov Russian Journal of Surgery. 2024;(7):45‑60. (In Russ.)
https://doi.org/10.17116/hirurgia202407145

Подписка 2025 (Pirogov Russian Journal of Surgery)
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OBJECTIVE

To analyze the features and outcomes of 500 liver transplantations in adults over a 12-year period.

MATERIALS AND METHODS

The study included data on 500 liver transplantations between May 2010 and April 2023. We analyzed 483 adults who underwent transplantation and 438 candidates for this procedure. All data were obtained from local liver transplantation registry. Clinical outcomes were recorded as of June 1, 2023. Statistical analysis was performed using the Statistica 12 (StatSoft Inc., USA) and Jamovi version 2.3.21.0 software (Jamovi project).

RESULTS

Among 438 patients in the waiting list between January 2012 and May 2023, liver transplantation was performed in 198 (45%) cases including 27 (6%) transplantations from living-related donors and 37 (8%) procedures in other centers. There were 109 (25%) deaths. The 1- and 3-year survival rates were 81% (95% CI 76—85%) and 50% (95% CI 42—59%), respectively. Organs from deceased donors (n=134, 27%) and living-related donors (n=366, 73%) were used for transplantations. Redo transplantations were necessary in 21 (4%) cases. The median age of recipients was 45 years (range 18—72), median MELD-Na score — 16 (range 6—43). The most common indications for transplantation were viral cirrhosis (37%), cholestatic liver disease (16%), and hepatocellular carcinoma (14%). Monotherapy with calcineurin inhibitors was performed in 39% of cases, combination of calcineurin inhibitors and glucocorticoids, antimetabolites or mTOR inhibitors — 52%, three-component schemes — 8% of cases. Annual, 5- and 7-year survival rates of recipients after primary transplantation were 87% (95% CI: 84—90%), 79% (95% CI: 75—83%) and 75% (95% CI: 70—80%), respectively. In case of liver transplantation from living-related donors, these values were 89% (95% CI: 86—92%), 84% (95% CI: 80—88%) and 80% (95% CI: 75—85%), after transplantation from deceased donors — 81% (95% CI: 74—88%), 66% (95% CI: 57—76%) and 58% (95% CI: 45—72%), respectively.

CONCLUSION

Liver transplantation is highly effective for patients with diffuse and focal liver diseases. Living donors not only significantly improve availability of this technology, but also provide substantial advantages in outcomes compared to liver transplantation from deceased donors, reducing the likelihood of recipient mortality by 10% after one post-transplantation year and by more than 20% after five years.

Keywords:

liver transplantation
liver cirrhosis
deceased donor
living-related donor
immunosuppression
survival

Authors:

Voskanyan S.E.

Burnasyan Federal Biophysical Center

Sushkov A.I.

Burnasyan Federal Biophysical Center

Artemiev A.I.

Burnasyan Federal Biophysical Center

Rudakov V.S.

Burnasyan Federal Biophysical Center

Kolyshev I.Yu.

Burnasyan Federal Biophysical Center

Gubarev K.K.

Burnazyan Federal Medical Biophysical Center of Federal Medical Biological Agency

Zabezhinskiy D.A.

Burnasyan Federal Biophysical Center

Popov M.V.

Burnasyan Federal Biophysical Center

Received:

15.11.2023

Accepted:

18.01.2024

List of references:

  1. Starzl TE, Marchioro TL, Vonkaulla KN, Hermann G, Brittain RS, Waddell WR. Homotransplantation of the liver in humans. Surgery, Gynecology and Obstetrics. 1963;117:659-676. 
  2. Konstantinov BA, Eramishantsev AK, Gotye SV, Tsirulnikova OM, Skipenko OG, Lebezev VM, Shertsinger AG, Lokshin LS. Orthotopic liver transplantation (first clinical experience). Pirogov Russian Journal of Surgery. 1993;3:32-44. (In Russ.).
  3. Shumakov VI, Moisyuk YG, Kozlov IA, Tarabarko NV, Petrova GN, Itkin GP, Matveev YG, Arzumanov VS, Nikolaenko EM, Gvozdev SV, Mogilevsky GM, Asriyan AG, Bazieva FK, Ermakova IP, Kosyrev AB. First experience with orthotopic transplantation of the liver in clinic. Pirogov Russian Journal of Surgery. 1991;1:98-105. (In Russ.).
  4. Gautier SV, Khomyakov SM. Organ donation and transplantation in the Russian Federation in 2021. 14th Report from the Registry of the Russian Transplant Society. Russian Journal of Transplantology and Artificial Organs. 2022;24(3):8-31. (In Russ.). https://doi.org/10.15825/1995-1191-2022-3-8-31
  5. Gautier SV, Khomyakov SM. Organ donation and transplantation in the Russian Federation in 2022. 15th Report from the Registry of the Russian Transplant Society. Russian Journal of Transplantology and Artificial Organs. 2023;25(3):8-30. (In Russ.). https://doi.org/10.15825/1995-1191-2023-3-8-30
  6. Olthoff KM, Kulik L, Samstein B, Kaminski M, Abecassis M, Emond J, Shaked A, Christie JD. Validation of a current definition of early allograft dysfunction in liver transplant recipients and analysis of risk factors. Liver Transplantation. 2010;16(8):943-949.  https://doi.org/10.1002/lt.22091
  7. Novruzbekov MS, Gulyaev VA, Lutsyk KN, Akhmetshin RB, Olisov OD, Magomedov KM, Kazymov BI, Yaremin BI, Khubutiya MS. Liver transplantation program at N.V. Sklifosovsky Research institute of emergency medicine: stages, achievements, and outlooks. Bulletin of the Medical Institute «REAVIZ» (Rehabilitation, Doctor and Health). 2020;(3):162-173. (In Russ.).
  8. Voskanyan SE, Artemyev AI, Sushkov AI, Kolyshev IY, Rudakov VS, Shabalin MV, Naydenov EV, Maltseva AP, Svetlakova DS. Vascular reconstruction and outcomes of 220 adult-to-adult right lobe living donor liver transplantations. Almanac of Clinical Medicine. 2018;46(6):598-608. (In Russ.). https://doi.org/10.18786/2072-0505-2018-46-6-598-608
  9. Voskanyan SE, Artemiev AI, Naidenov EV, Kolyshev IYu, Shabalin MV, Bashkov AN, Chursin DV, Subkhonov KhA, Raspopov DS. Vascular reconstructions and transplant technologies in liver surgery (part I). Pirogov Russian Journal of Surgery. 2023;(1):46-55. (In Russ.). https://doi.org/10.17116/hirurgia202301146
  10. Voskanyan SE, Kolyshev IY, Bashkov AN, Artemiev AI, Rudakov VS, Shabalin MV, Maltseva AP, Popov MV, Sushkov AI, Vohmyanin GV. Efferent blood supply to the right hepatic lobe regarding its transplantation from a living donor: variant anatomy, classification. Part 1. Annals of HPB Surgery. 2023;28(1):10-24. (In Russ.). https://doi.org/10.16931/1995-5464.2023-1-10-24
  11. Voskanyan SE, Kolyshev IY, Bashkov AN, Artemiev AI, Rudakov VS, Shabalin MV, Maltseva AP, Popov MV, Sushkov AI, Vohmyanin GV. Efferent blood supply to the right hepatic lobe regarding its transplantation from a living donor: reconstruction features. Part 2. Annals of HPB Surgery. 2023;28(2):59-69. (In Russ.). https://doi.org/10.16931/1995-5464.2023-2-59-69
  12. Voskanyan SE, Artemyev AI, Sushkov AI., Gubarev KK, Svetlakova DS, Popov MV, Rudakov VS, Bashkov AN, Naydenov EV, Muktarzhan M. Modified cavocavostomy technique for deceased donor liver transplantation. Transplantologiya. The Russian Journal of Transplantation. 2022;14(2):142-158. (In Russ.). https://doi.org/10.23873/2074-0506-2022-14-2-142-158
  13. Voskanyan SE, Artemiev AI, Naidenov EV, Gubarev KK, Kolyshev IY, Rudakov VS, Zabezhinsky DA, Bashkov AN, Sushkov AI, Popov MV, Fozilov MM, Svetlakova DS, Maltseva AP. Liver transplantation for cirrhosis complicated by non-tumor thrombosis of mesenteric portal system. Annals of HPB Surgery. 2022;27(4):71-83. (In Russ.). https://doi.org/10.16931/1995-5464.2022-4-71-83
  14. Voskanyan SE, Popov MV, Maltseva AP, Artemiev AI, Kolyshev IY, Zabezhinskii DA, Sushkov AI, Rudakov VS, Bashkov AN, Dunaev AP, Muktarzhan M, Sadykhov ZA. Biliary reconstruction during right lobe living donor liver transplantation: state of the problem, options and classification. Annals of HPB Surgery. 2020;25(4):33-48. (In Russ.). https://doi.org/10.16931/1995-5464.2020433-48
  15. Voskanyan SE, Popov MV, Artemiev AI, Sushkov AI, Kolyshev IY, Rudakov VS, Maltseva AP, Zabezhinskiy DA. Bilary anastomotic strictures after right lobe living donor liver transplantation: a single-center experience. Pirogov Russian Journal of Surgery. 2021;2:5-13. (In Russ.). https://doi.org/10.17116/hirurgia20210215
  16. Popov MV, Voskanyan SE, Artemiev AI, Sushkov AI, Aronov MS, Kolyshev IY, Shcherbin VV, Maltseva AP, Rudakov VS, Bashkov AN, Sadykhov ZA, Muktarzhan M. Short-term results of percutaneous transhepatic interventions for anastomotic biliary strictures after living donor liver transplantation using a right lobe graft. Clinical and Experimental Surgery. Petrovsky Journal. 2020;8(4):143-53. (In Russ.). https://doi.org/10.33029/2308-1198-2020-8-4-143-153
  17. Sushkov AI, Gubarev KK, Vinogradov VL, Rudakov VS, Svetlakova DS, Fedyunin AA, Krstich M, Zakhlevnyy AI, Artemiev AI, Voskanyan SE. Impact of long-distance (up to 3.500 km) deceased donor liver transportation on cold ischemia time, initial graft function and transplant outcomes. The Russian Journal of Transplantation. 2021;13(1):10-24. (In Russ.). https://doi.org/10.23873/2074-0506-2021-13-1-10-24
  18. Sushkov AI, Voskanyan SE, Rudakov VS, Popov MV, Gubarev KK, Svetlakova DS, Artemiev AI. Interstitial Glucose Metabolism Monitoring as an Additional Method for Objective Assessment of Donor Liver, Prediction and Immediate Diagnosis of Early Graft Dysfunction. Sovremennye tehnologii v medicine. 2022;14(3):28. (In Russ.). https://doi.org/10.17691/stm2022.14.3.04
  19. Sushkov AI, Popov MV, Rudakov VS, Svetlakova DS, Pashkov AN, Lukianchikova AS, Muktarzhan M, Gubarev KK, Syutkin VE, Artemyev AI, Voskanyan SE. Comparative analysis of models predicting the risks of early poor outcome of deceased-donor liver transplantation: a retrospective single-center study. The Russian Journal of Transplantation. 2023;15(3):312-333. (In Russ.). https://doi.org/10.23873/2074-0506-2023-15-3-312-333
  20. Voskanyan SE, Chuchuev ES, Rudakov VS, Popov MV, Zamyatkin AA. Postoperative result prediction in patients with hepatocellular carcinoma. Clinical and Experimental Surgery. Petrovsky Journal. 2021;9(3):51-58. (In Russ.). https://doi.org/10.33029/2308-1198-2021-9-3-51-58
  21. Voskanyan SE, Sushkov AI, Artemiev AI, Zabezhinskiyi DA, Naidyonov EV, Bashkov AN, Chuchuev ES, Shabalin MV, Syutkin VE. Salvage liver transplantation for hepatocellular carcinoma. Pirogov Russian Journal of Surgery. 2019;10:21-28. (In Russ.). https://doi.org/10.17116/hirurgia201910121
  22. Voskanyan SE, Naidenov EV, Artemiev AI, Kolyshev IY, Zabezhinsky DA, Gubarev KK, Rudakov VS, Shabalin MV, Sushkov AI, Popov MV, Svetlakova DS, Maltseva AP, Muktarzhan M, Sadykhov Z, Vidmer EV. Long-term results of liver transplantation for hepatocellular cancer. Annals of HPB Surgery. 2021;26(2):68-82. (In Russ.). https://doi.org/10.16931/10.16931/1995-5464.2021-2-68-82
  23. Voskanyan SE, Artemiev AI, Naidenov EV, Zabezhinsky DA, Shabalin MV, Popov MV, Bashkov AN, Gubarev KK, Rudakov VS, Vidmer EV, Zhurbin AS. Liver transplantation for metastases from neuroendocrine tumors: a literature review and clinical observation. Annals of HPB Surgery. 2022;27(3):33-45. (In Russ.). https://doi.org/10.16931/1995-5464.2022-3-33-45
  24. Bashkov AN, Sheykh ZV, Voskanyan SE, Dunaev AP, Popov MV, Naydenov EV, Shabalin MV, Safonov AS. Possibilities of Computed Tomography in the Planning of Inferior Vena Cava Resection in Patients with Liver Alveococcosis. Journal of radiology and nuclear medicine. 2019;100(3):145-151. (In Russ.). https://doi.org/10.20862/0042-4676-2019-100-3-145-151
  25. Voskanyan SE, Bashkov AN, Karmazanovsky GG, Naydenov EV, Ionova EA. Planning principles for radical surgical intervention for liver alveococcosis based on computed and magnetic resonance imaging. Annals of HPB Surgery. 2020;25(2):100-112. (In Russ.). https://doi.org/10.16931/1995-5464.20202100-112
  26. Zagainov VE, Porshennikov IA, Kiselev NM, Naydenov EV, Pavlik VN, Voskanyan SE. New classification of alveolar echinococcosis of the liver as a base of new surgical strategy. A multicenter study. Annals of HPB Surgery. 2020;25(4):20-32. (In Russ.). https://doi.org/10.16931/1995-5464.2020420-32
  27. Voskanyan SE, Sushkov AI, Rudakov VS, Svetlakova DS, Popov MV, Pashkov AN, Muktarzhan M, Lukianchikova AS. Clinical course and outcomes of COVID-19 infection in liver transplant recipients: single-center cross-sectional study. The Russian Journal of Transplantation. 2022;14(1):20-33. (In Russ.). https://doi.org/10.23873/2074-0506-2022-14-1-20-33
  28. Voskanyan SE, Artemiev AI, Zabezhinskiyi DA, Shabalin MV, Bashkov AN. Laparoscopic donor right hemihepatectomy (first experience In Russia). Endoscopic Surgery. 2017;23(3):37-40. (In Russ.). https://doi.org/10.17116/endoskop201723337-40
  29. Voskanyan SE, Kolyshev IYu, Shabalin MV, Artemyev AI, Rudakov VS, Maltseva AP, Bashkov AN, Syutkin VE, Gubarev KK, Svetlakova DS. Full-split liver transplantation. The first experience In Russian Federation. Annals of HPB Surgery. 2021;26(1):66-75. (In Russ.). https://doi.org/10.16931/1995-5464.2021166-75
  30. Voskanyan SE, Syutkin VE, Maltseva AP, Rudakov VS, Svetlakova DS, Davtyan AA, Simavonyan ZK, Gallyamova AR, Probatova NA, Gorodetskiy VR, Stolyarevich ES, Udalov YD, Samoylov AS. Hemophagocytic syndrome and Kaposi sarcoma after liver transplantation. The Russian Journal of Transplantation. 2018;10(2):126-141. (In Russ.). https://doi.org/10.23873/2074-0506-2018-10-2-126-141
  31. Voskanyan SE, Korobka VL, Syutkin VE, Monakhov AR, Maltseva AP, Pak ES, Korobka RV, Kolodyazhny EI, Zubenko SI, Voskanyan YV, Kotsiyaev VY. Development of graft-versus-host disease in a liver recipient. Clinical observations and literature review. Russian Journal of Transplantology and Artificial Organs. 2023;25(3):38-49. (In Russ.). https://doi.org/10.15825/1995-1191-2023-3-38-49

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