Liver cirrhosis, occupying one of the main places among the diseases of humanity, is among the ten chronic diseases that increase disability and mortality rates.

OBJECTIVE

To study the etiological, epidemiological, clinical and diagnostic features of liver cirrhosis, as well as the possibilities of improving measures of its prevention in rural residents of the Andijan region.

MATERIAL AND METHODS

The study subject was a representative 10% sample of 6952 residents of the Marhamat district aged between 18 and 70 years, of whom 694 were included in the research, among them 203 (29.3%) were men and 491 (70.7%) — women. Epidemiological, general clinical, instrumental, laboratory and statistical study methods were used to achieve the objectives.

RESULTS

It has been established during course of retrospective and prospective studies of chronic liver diseases in rural residents of the Marhamat district of the Andijan region for 2017—2021, that liver cirrhosis had a predominantly viral etiology (46.1%) in examined individuals. Liver cirrhosis of alcoholic etiology was more common in persons aged 60—69 years, liver cirrhosis of viral etiology — in persons aged 40—49 years, liver cirrhosis of unclear etiology — in persons aged 20—29 years. A portal hypertensive gastropathy of the upper gastrointestinal tract was revealed in 55% of patients with liver cirrhosis.

CONCLUSION

Morbidity and mortality rates from diseases of the digestive system, including liver cirrhosis and its complications, have increased in recent years. The possibilities for improving the preventive measures of this pathology consist in increasing the patients’ coverage by regular check-up, conducting epidemiological monitoring of the results of early prevention of liver cirrhosis and its complications, as well as raising public awareness of this disease.