Current possibilities of correcting subchondral bone resorption as a major pathogenetic factor for progressive osteoarthrosis

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Journal: Therapeutic Archive. 2014;86(1): 60‑65

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To cite this article:

Current possibilities of correcting subchondral bone resorption as a major pathogenetic factor for progressive osteoarthrosis. Therapeutic Archive. 2014;86(1):60‑65. (In Russ.)

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The paper considers the current pathogenesis, by choosing the actual targets of pharmacotherapy with available drugs. It reflects the cytokine mechanisms responsible for lesion of the synovial membranes, cartilage, and subchondral bone. Particular emphasis is laid on the role of chondroitin sulfate, glucosamine, vitamin D3 as drugs that affect the key components of pathogenesis, including the volume of resorptive cavities in the subchondral bone.

Keywords:

osteochondrosis

subchondral bone

resorption

cytokines

metalloproteinase

chondroitin sulfate

glucosamine

vitamin D3

combined chondroitin and glucosamine dru

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