Cytokines/chemokines profiles characterizing the body’s response to disease are not still investigated despite the numerous studies.

OBJECTIVE

To examine the distribution of therapeutic diseases in young people of working and childbearing age depending on levels of some cytokines/chemokines.

MATERIAL AND METHODS

The study included 1340 subjects aged 25—44 years. The levels of interleukin-6 (IL-6), monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor-alpha (TNF-α) and their associations with some therapeutic diseases, namely hypercholesterolemia, low-density lipoproteins, coronary heart disease, type 2 diabetes mellitus, arterial hypertension, renal dysfunction, chronic bronchitis, were determined by multiplex analysis method.

RESULTS

The highest incidence of therapeutic diseases was found at an increased IL-6 level. The prevalence of renal dysfunction is associated with high IL-6 and TNF-α values, arterial hypertension is more common at high IL-6 values. The chance of having renal dysfunction is associated with TNF-α equal more than 7.26 pg/ml (OR=3.282; 95% CI 1.330— 3.951; p<0.003). The chance of having arterial hypertension increases 4 times in the third quartile of IL-6 level compared to the first (OR=3.799; 95% CI 1.531—9.428; p=0.004) and remains in the fourth — IL-6 (OR=4.037; 95% CI 1.622—10.046; p=0.003).

CONCLUSION

The highest incidence of therapeutic diseases was found at increased IL-6 level. The distribution of renal dysfunction is associated with high IL-6 and TNF-α values, arterial hypertension is more common at high IL-6 values.