Reparative potential of bone tissue and associated influencing factors

Close metadata

OBJECTIVE

The aim of the sthudy. To study the influence of general and local factors on the regenerative potential of bone tissue to optimize augmentation mechanisms in the treatment of jaw atrophy.

MATERIALS AND METHODS

The influence of general and local factors on the regenerative potential of the bone during the augmentation operation of the alveolar process (part) of the jaw in 68 patients was studied. The survival rate of dental implants and the incidence of complications after completion of dental rehabilitation in the long-term follow-up period (more than 5 years) were evaluated. 18 indicators were studied, which were evaluated by qualitative and quantitative methods. The study of the effect of indicators on regeneration was carried out using an accurate Fischer test for conjugacy tables. The assessment of the strength of the influence was calculated as the ratio of the chances of developing an unfavorable outcome of bone grafting and dental implantation.

RESULTS

He highest chances of developing adverse outcomes were found in smoking patients with diabetes mellitus, high body mass index, low survival of bone walls, severe bone atrophy (5.6 and higher class according to Cawood & Howell), three-dimensional bone defect, in the absence of 3 or more bone walls, the presence of subcompensated and decompensated psychological state the patient. In the course of histological examination, the influence of these factors on the mechanisms of reparative osteogenesis morphologically manifested a lower degree of progress of regenerative processes and a lower degree of maturity of bone tissue.

CONCLUSION

To reduce the chances of developing an unfavorable outcome, in the presence of negative general and local factors, it is not advisable to use dental implantation simultaneously with bone augmentation procedures. In order to reduce the pathophysiological impact of negative factors during sinus lifting, increase the proportion of autosteal material for potentiating the metabolic activity of bone tissue, as well as prescribe antioxidant, antihypoxant and membrane stabilizing therapy before surgery and in the early postoperative period.

Keywords:

dental implantation

bone augmentation

risk factors

bone atrophy

prognosis of bone grafting

Authors:

Muzikin M.I.

Saint-Petersburg Medico-Social Institute;
Saint-Petersburg Research Institute of Ear, Throat, Nose and Speech;
S.M. Kirov Military-Medical Academy

ORCID: 0000-0003-1941-7909

Iordanishvili A.K.

Saint-Petersburg Medico-Social Institute;
S.M. Kirov Military-Medical Academy;
I.I. Mechnikov North-Western State Medical University

ORCID: 0000-0003-0052-3277

Losev F.F.

Central Research Institute of Dentistry and Maxillofacial Surgery of the Ministry of Health of Russia

ORCID: 0000-0001-6689-4180

Grigoriev S.G.

S.M. Kirov Military-Medical Academy

ORCID: 0000-0001-9365-0122

Received:

27.04.2023

Accepted:

10.10.2023

List of references:

Araújo MG, Silva CO, Souza AB. Socket healing with and without immediate implantplacement. Periodontology 2000. 2019;79:168-177. https://doi.org/10.1111/prd.12252
Crespi R, Cappare P, Gastaldi G, Gherlone E. Reactive Soft Tissue Preservation in Large Bone Defects After Tooth Extractions: A Cone Beam. Int. J Oral Maxillofac Implants. 2016;204-206. https://doi.org/10.11607/jomi.4199
Muzikin MI, Iordanishvili AK. Model of sanogenesis of postextraction regeneration of jaw bone tissue. Ekologiya cheloveka. 2020;8:40-48. (In Russ.). https://doi.org/10.33396/1728-0869-2020-8-40-48
Deev RV. Angiogenesis is normal, with the development of pathological conditions and induction of reparative processes. Geny I kletki. 2019;14(3):35-36. (In Russ.).
Silva-Junior MF, de Sousa CC, Batista MJ, Rosário de Sousa M. da L. Oral health condition and reasons for tooth extraction among an adult population (20-64 years old). Cien Saude Colet. 2017;2693-2702.
Muzikin MI, Kokovikhina EV, Gerasimova EA, Mishchuk VF, Iordanishvili AK, Slesarev OV. Age-related and postextraction atrophy of the jaws and modern possibilities of restoring the chewing apparatus in the elderly and old people. Uspekhi gerontologii. 2021;1:62-68. (In Russ.).
Hernández-Monjaraz B, Santiago-Osorio E, Ledesma-Martínez E, Aguiñiga-Sánchez I, Sosa-Hernández NA, Mendoza-Núñez VM. Dental Pulp Mesenchymal Stem Cells as a Treatment for Periodontal Disease in Older Adults. Stem Cells Int. 2020;18:1-5. https://doi.org/10.1155/2020/8890873
Iordanishvili AK, Muzikin MI, Losev FF. Chewing reflex: features of its manifestation in mucositis and periimplantitis. Periodontologiya. 2021;4:308-315. (In Russ.). https://doi.org/10.33925/1683-3759-2021-26-4-308-315
Adamo D, Pecoraro G, Fortuna G, Amato M, Marenzi G, Aria M, Mignogna MD. Assessment of oral health-related quality of life, measured by OHIP-14 and GOHAI, and psychological profiling in burning mouth syndrome: A case-control clinical study. J Oral Rehabil. 2020;47(1):42-52. https://doi.org/10.1111/joor.12864
Balin VN, Balin DV, EV. Shengelia, Iordanishvili A.K. Muzikin M.I. Osteostimulating effect of xenogenic bone material on reparative osteogenesis (experimental morphological study). Stomaologiya. 2015;94(2):5-9. (In Russ.).
Chappuis V, Araújo MG, Buser D. Clinical relevance of dimensional bone and soft tissue alterations post-extraction in esthetic sites. Periodontology 2000. 2017;23(7):73-83. https://doi.org/10.1111/prd.12167
Cheng LL. Alveolar ridge preservation with bone graft may limit physiological ridge loss after tooth extraction. J Am Dent Assoc. 2016;204-206. https://doi.org/10.1016/j.adaj.2015.12.015
Muzikin MI, Grebnev GA, Iordanishvili AK, Tereshchuk SV, Melnikov MV. Dental rehabilitation of complete adentia in pensioners of the Ministry of Defense and attached contingent in military medical organizations. Vestnik Russiiskoi Voenno-Meditsinskoi Academii. 2020;2(70):94-105. (In Russ.). https://doi.org/10.17816/brmma50053
Levi I, Halperin-Sternfeld M, Horwitz J, Zigdon-Giladi, Machtei EE. Dimensional changes of the maxillary sinus following tooth extraction in the posterior maxilla with and without socket preservation. Clin Implant Dent Relat Res. 2017;35-36. https://doi.org/10.1111/cid.12521
Candel-Martí E, Peñarrocha-Oltra D, Bagá NL, Peñarrocha-Diago M, Peñarrocha-Diago M. Palatal positioned implants in severely atrophic maxillae versus conventional implants to support fixed full-arch prostheses: Controlled retrospective study with 5 years of follow-up. Med Oral Patol Oral Y Cir Bucal. 2015;20:357-364. https://doi.org/10.4317/medoral.20262
Muzikin MI, Iordanishvili AK, Balin DV. Survival of zygomatic and root dental implants: a five-year follow-up. Russiiskii vestnik Dentalnoi Implantologii. 2020;3-4(49-50):60-69. (In Russ.).
Stamboliev IA, Gazhva YuV, Ivashkevich SG, Ryabova VM. Modern approachesto bone tissue engineering. Russisskii stomatologicheskii zhurnal. 2018;22(2):111-116. (In Russ.). https://doi.org/10.18821/1728-2802-2018-22-2-111-116
Malyshev ME, Iordanishivili AK, Prisyazhnyuk OV, Bumai AO. The effect of probiotics on the secretory immunity of saliva in patients with type 2 diabetes. Stomatologiya. 2019;98(6):26-29. (In Russ.). https://doi.org/10.17116/stomat20199806126
Junkerov VI, Grigoriev SG, Rezvantsev MV. Mathematical and statistical processing of medical research data. St. Petersburg. 2011. (In Russ.).

Close metadata