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Zorina O.A.

National Medical Research Center for Dental and Maxillofacial Surgery of Ministry of Health of the Russian Federation;
I.M. Sechenov First Moscow State Medical University (Sechenov University)

Amkhadova M.A.

Moscow Regional Research Clinical Institute named after M.F.Vladimirsky

Khamukova A.A.

Republican Dental Center

Aleskerov E.Sh.

Moscow Regional Research Clinical Institute named after M.F.Vladimirsky

Ajrapetov G.A.

National Medical Oncology Research Center of Ministry of Health of the Russian Federation

Demidova A.A.

Rostov State Medical University of Ministry of Health of the Russian Federation

Osteoimmunological aspects of periodontal inflammatory destructive changes at periimplantitis, chronic periodontitis and oncological diseases of the oral cavity

Authors:

Zorina O.A., Amkhadova M.A., Khamukova A.A., Aleskerov E.Sh., Ajrapetov G.A., Demidova A.A.

More about the authors

Journal: Stomatology. 2020;99(4): 27‑32

DOI: 10.17116/stomat20209904127

Read: 2870 times

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Table of contents

OSTEOIMMUNOLOGICAL ASPECTS OF PERIODONTAL INFLAMMATORY DESTRUCTIVE CHANGES AT PERIIMPLANTITIS, CHRONIC PERIODONTITIS AND ONCOLOGICAL DISEASES OF THE ORAL CAVITY
OSTEOIMMUNOLOGICAL ASPECTS OF PERIODONTAL INFLAMMATORY DESTRUCTIVE CHANGES AT PERIIMPLANTITIS, CHRONIC PERIODONTITIS AND ONCOLOGICAL DISEASES OF THE ORAL CAVITY

To cite this article:

Zorina OA, Amkhadova MA, Khamukova AA, Aleskerov ESh, Ajrapetov GA, Demidova AA. Osteoimmunological aspects of periodontal inflammatory destructive changes at periimplantitis, chronic periodontitis and oncological diseases of the oral cavity. Stomatology. 2020;99(4):27‑32. (In Russ.)
https://doi.org/10.17116/stomat20209904127

 
Подписка 2026 Стоматология (Stomatology)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

THE AIM OF THE STUDY

Was to analyze possible correlation between the concentration of the pro-inflammatory cytokine interleukin-6 and the activation marker of osteoclasts cathepsin K in the gingival fluid during osteoresorption of inflammatory (periimplantitis, chronic generalized periodontitis) and malignant oncological origin (malignant neoplasm of gums).

MATERIALS AND METHODS

The study comprised 87 individuals of both sexes aged 30 to 60: 20 patients (group 1) with periimplantitis, 30 people with chronic generalized periodontitis (CGP) (group 2), 22 patients with squamous cell carcinoma of the upper and lower alveolar bone gingiva (group 3), 15 healthy individuals without periodontal disease.

RESULTS

The concentration of interleukin-6 (IL-6) and cathepsin K was determined in the gingival fluid by enzyme-linked immunosorbent assay. The examination revealed that during CGP and peri-implantitis the accumulation of IL-6 in the contents of periodontal and peri-implantation pockets was a pathogenetic factor for the activation of osteoclasts and their secretion of proteolytic enzymes osteoresorption. In cancer the increase of cathepsin K expression was a lot higher than the accumulation of IL-6 in the gingival fluid reducing the dependence of the activation of osteoclasts on the local accumulation of pro-inflammatory cytokines. Conclusion. To formulate the prognosis of progressive bone loss in patients with peri-implantitis it is necessary to control the concentration of IL-6 and cathepsin K in the peri-implantation pocket, in case of CGP the concentration of IL-6 in the exudate of the periodontal pocket and in patients with cancer of the alveolar processes the content of cathepsin K of gingival fluid.

Keywords:

osteoresorption
interleukin-6
cathepsin K
chronic periodontitis
periimplantitis
malignant gums neoplasm

Authors:

Zorina O.A.

National Medical Research Center for Dental and Maxillofacial Surgery of Ministry of Health of the Russian Federation;
I.M. Sechenov First Moscow State Medical University (Sechenov University)

Amkhadova M.A.

Moscow Regional Research Clinical Institute named after M.F.Vladimirsky

Khamukova A.A.

Republican Dental Center

Aleskerov E.Sh.

Moscow Regional Research Clinical Institute named after M.F.Vladimirsky

Ajrapetov G.A.

National Medical Oncology Research Center of Ministry of Health of the Russian Federation

Demidova A.A.

Rostov State Medical University of Ministry of Health of the Russian Federation

Received:

17.06.2020

Accepted:

25.06.2020

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References:

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