Effect of urolithin A on production of interleukins 6 and 10 by immune cells from patients with MS and healthy donors

Kukushkina A.D.; Rogovsky V.S.; Boyko A.N.

doi:https://doi.org/10.17116/jnevro202512507284

Kukushkina A.D.

Federal Center for Brain and Neurotechnologies;
Municipal Clinical Hospital named after M.E. Zhadkevych

ORCID: 0000-0001-9964-8103

Rogovsky V.S.

Federal Center for Brain and Neurotechnologies;
N.I. Pirogov Russian National Research Medical University (Pirogov University)

SPIN RSCI: 8319-1426
Scopus AuthorID: 37031850500
ORCID: 0000-0002-3682-6571

Boyko A.N.

Federal Center for Brain and Neurotechnologies;
N.I. Pirogov Russian National Research Medical University (Pirogov University)

SPIN RSCI: 9921-9109
Scopus AuthorID: 7102247663
ORCID: 0000-0002-2975-4151

Effect of urolithin A on production of interleukins 6 and 10 by immune cells from patients with MS and healthy donors

Authors:

Kukushkina A.D., Rogovsky V.S., Boyko A.N.

More about the authors

Journal: S.S. Korsakov Journal of Neurology and Psychiatry. 2025;125(7‑2): 84‑88

DOI: 10.17116/jnevro202512507284

Read: 572 times

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To cite this article:

Kukushkina AD, Rogovsky VS, Boyko AN. Effect of urolithin A on production of interleukins 6 and 10 by immune cells from patients with MS and healthy donors. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;125(7‑2):84‑88. (In Russ.)
https://doi.org/10.17116/jnevro202512507284

Подписка 2026 Журнал неврологии и психиатрии им. С.С. Корсакова. Спецвыпуски (S.S. Korsakov Journal of Neurology and Psychiatry (special issues))

Использование инфографики авторами научных работ

OBJECTIVE

To study the effect of urolithin A on cytokine production in multiple sclerosis (MS) patients and healthy donors.

MATERIAL AND METHODS

The effect of urolithin A on stimulated production of interleukin (IL)-6 and interleukin-10 by peripheral blood mononuclear cells (PBMCs) and macrophages in patients with MS and healthy donors was evaluated using enzyme immunoassay.

RESULTS

Basal and lipopolysaccharide-stimulated production of IL-10 PBMCs in patients with MS is lower than in healthy donors. In contrast, basal and stimulated production of IL-6 by PBMCs is higher in patients with MS compared to healthy donors. Urolithin A at 5 μM contributed to an increase in the production of IL-10 by PBMCs both in MS patients (by an average of 28%) and in healthy donors. Urolithin A also caused a decrease in the macrophage production of IL-6 in healthy donors (by an average of 10%) and MS patients.

CONCLUSION

Given the beneficial immunotropic effect of urolithin A, this metabolite of the intestinal microbiota can be considered a promising compound for further study in patients with MS, including in clinical placebo-controlled studies.

Keywords:

multiple sclerosis

polyphenols

urolithin A

interleukin-6

interleukin-10

Authors:

Kukushkina A.D.

Federal Center for Brain and Neurotechnologies;
Municipal Clinical Hospital named after M.E. Zhadkevych

ORCID: 0000-0001-9964-8103

Rogovsky V.S.

Federal Center for Brain and Neurotechnologies;
N.I. Pirogov Russian National Research Medical University (Pirogov University)

SPIN RSCI: 8319-1426
Scopus AuthorID: 37031850500
ORCID: 0000-0002-3682-6571

Boyko A.N.

Federal Center for Brain and Neurotechnologies;
N.I. Pirogov Russian National Research Medical University (Pirogov University)

SPIN RSCI: 9921-9109
Scopus AuthorID: 7102247663
ORCID: 0000-0002-2975-4151

Received:

07.06.2025

Accepted:

13.06.2025

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References:

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