The aim of the study was to study hemodynamic parameters in patients with a local form of odontogenic infection (LFOI) in the presence of diseases of the cardiovascular system and without background pathology. 5 groups were formed: group 1 — patients with LFOI without background diseases (49 patients, mean age 29 [25; 37] years); group 2 — healthy individuals (25 people, mean age 24.7±0.76 years); group 3 — patients with LFOI and diseases of the cardiovascular system (34 patients, mean age 51.2±2.37 years); group 4 — patients without LFOI with diseases of the cardiovascular system (25 patients, mean age — 46 [43; 50] years); group of patients with LFOI without background pathology, comparable in age and sex composition with group 3 (group 5, 28 patients, mean age 48.9±2.30 years). The presence of LFOI in the patient in the absence of background pathology determines the heart rate (78 [72; 82] in 1 min) in comparison with the control group of healthy individuals (68.0±0.85 in 1 min), the values of minute volume of blood circulation (5.25±0.14 l/min) and systolic index (2.87 [2.56; 3.35]) l·m–2·min–1. The development of LFOI in patient with hypertension/ischemic heart disease was not associated with increased blood circulation features, such as the increase in resting heart rate values, the values of minute volume of blood circulation and systolic index.