Radionuclide methods in analysis of myocardial perfusion and metabolic activity

Yurchenko A.A.; Kharina D.S.; Mosin D.Yu.; Bashirova M.V.; Novikova N.A.; Znamenskiy I.A.; Butenko A.V.

doi:https://doi.org/10.17116/rbpdpm2024104112

Yurchenko A.A.

Petrovsky National Research Centre of Surgery

ORCID: 0000-0002-9392-9649

Kharina D.S.

Petrovsky National Research Centre of Surgery

ORCID: 0000-0002-8822-8661

Mosin D.Yu.

Petrovsky National Research Centre of Surgery;
Pirogov Russian National Research Medical University

ORCID: 0000-0001-8317-4097

Bashirova M.V.

Petrovsky National Research Centre of Surgery

ORCID: 0000-0001-8578-2715

Novikova N.A.

Petrovsky National Research Centre of Surgery

ORCID: 0000-0002-3639-270X

Znamenskiy I.A.

Petrovsky National Research Centre of Surgery;
Pirogov Russian National Research Medical University

ORCID: 0000-0003-0305-6723

Butenko A.V.

Petrovsky National Research Centre of Surgery

ORCID: 0000-0003-4390-9276

Radionuclide methods in analysis of myocardial perfusion and metabolic activity

Authors:

Yurchenko A.A., Kharina D.S., Mosin D.Yu., Bashirova M.V., Novikova N.A., Znamenskiy I.A., Butenko A.V.

More about the authors

Journal: Regenerative Biotechnologies, Preventive, Digital and Predictive Medicine. 2024;1(4): 12‑19

DOI: 10.17116/rbpdpm2024104112

Read: 1029 times

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To cite this article:

Yurchenko AA, Kharina DS, Mosin DYu, Bashirova MV, Novikova NA, Znamenskiy IA, Butenko AV. Radionuclide methods in analysis of myocardial perfusion and metabolic activity. Regenerative Biotechnologies, Preventive, Digital and Predictive Medicine. 2024;1(4):12‑19. (In Russ.)
https://doi.org/10.17116/rbpdpm2024104112

Подписка 2026 Восстановительные биотехнологии, профилактическая, цифровая и предиктивная медицина (Regenerative Biotechnologies, Preventive, Digital and Predictive Medicine)

Использование инфографики авторами научных работ

OBJECTIVE

To compare the effectiveness of combined diagnostic algorithm for coronary artery disease involving myocardial PET/CT with ¹⁸F-FDG and PET/CT with ⁸²Rb-chloride, as well as algorithm including myocardial PET/CT with ¹⁸F-FDG and SPECT/CT with ⁹⁹mTc-chloride.

MATERIAL AND METHODS

The study involved 24 patients aged 34—60 years with coronary artery disease. All patients underwent perfusion SPECT/CT with ⁹⁹mTc-Technetrile at rest and stress test (bicycle ergometer), as well as metabolic PET/CT with ¹⁸F-FDG. A protocol for perfusion PET/CT with ⁸²Rb-chloride was developed.

RESULTS

SPECT revealed signs of focal cicatricial changes in 4 patients and signs of myocardial perfusion defect in 13 patients. Contractility impairment zones were observed in 14 patients. When analyzing the PET/CT data, areas of reduced metabolism partially or completely corresponding to perfusion deficiency were detected in 16 patients.

CONCLUSION

These data completely coincided with angiography results. We plan the final stage of the study after receiving the 82Sr/82Rb generator.

Keywords:

82Sr/82Rb generator

82Rb-chloride

PET/CT

SPECT/CT

coronary artery disease

Authors:

Yurchenko A.A.

Petrovsky National Research Centre of Surgery

ORCID: 0000-0002-9392-9649

Kharina D.S.

Petrovsky National Research Centre of Surgery

ORCID: 0000-0002-8822-8661

Mosin D.Yu.

Petrovsky National Research Centre of Surgery;
Pirogov Russian National Research Medical University

ORCID: 0000-0001-8317-4097

Bashirova M.V.

Petrovsky National Research Centre of Surgery

ORCID: 0000-0001-8578-2715

Novikova N.A.

Petrovsky National Research Centre of Surgery

ORCID: 0000-0002-3639-270X

Znamenskiy I.A.

Petrovsky National Research Centre of Surgery;
Pirogov Russian National Research Medical University

ORCID: 0000-0003-0305-6723

Butenko A.V.

Petrovsky National Research Centre of Surgery

ORCID: 0000-0003-4390-9276

Received:

29.09.2024

Accepted:

15.10.2024

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References:

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