The aim of the study is to implement the national project created within the framework of the state task of the Ministry of Education and Science of the Russian Federation «Development of the program of screening of cancer and precancerous diseases of the oral mucosa and red border of the lips». For its approbation and implementation, national research groups have been created at the bases of the Department of Therapeutic Dentistry of the Moscow State Medical and Dental University, the Tula regional dental clinic, City dental clinic in Noyabrsk City (Yamal-Nenets autonomous district), which in the period from 2015 to the first half of 2018 studied the epidemiology of cancer and precancer of the oral mucosa and the vermilion among 217 806 people aged 18—92 years. Over three and a half years, the effectiveness of the research team increased by 8.45 times. The results of the study confirmed the low oncological alertness of dentists. Educational working program for dentists training «Screening of diagnostics of precancerous diseases and cancer of the oral mucosa — AFS-D Set» was developed by coordinators of the project and implemented for training of 574 dentists within continuous medical education programs.