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Churnosov V.I.

Belgorod State National Research University, Belgorod, Russia

Ponomarenko I.V.

Belgorod State National Research University, Belgorod, Russia

Churnosov M.I.

Belgorod State National Research University, Belgorod, Russia

Single nucleotide polymorphism of the SLC22A10 gene and the risk of endometrial hyperplasia

Authors:

Churnosov V.I., Ponomarenko I.V., Churnosov M.I.

More about the authors

Journal: Russian Bulletin of Obstetrician-Gynecologist. 2026;26(1): 5‑11

DOI: 10.17116/rosakush2026260115

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Table of contents

SINGLE NUCLEOTIDE POLYMORPHISM OF THE SLC22A10 GENE AND THE RISK OF ENDOMETRIAL HYPERPLASIA
SINGLE NUCLEOTIDE POLYMORPHISM OF THE SLC22A10 GENE AND THE RISK OF ENDOMETRIAL HYPERPLASIA

To cite this article:

Churnosov VI, Ponomarenko IV, Churnosov MI. Single nucleotide polymorphism of the SLC22A10 gene and the risk of endometrial hyperplasia. Russian Bulletin of Obstetrician-Gynecologist. 2026;26(1):5‑11. (In Russ.)
https://doi.org/10.17116/rosakush2026260115

Подписка 2026 Российский вестник акушера-гинеколога (Russian Bulletin of Obstetrician-Gynecologist)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To evaluate the association of a single nucleotide polymorphism (SNP) associated with sex hormone levels with the risk of endometrial hyperplasia (EH) in women with normal body weight.

MATERIAL AND METHODS

The study was conducted on a sample of 766 women (196 patients with EH and 570 in the comparison group) with a body mass index (BMI) <25 kg/m². Genotyping of four polymorphisms (rs34670419 G>T ZKSCAN5, rs1641549 C>T TP53, rs148982377 T>C ZNF789, rs112295236 C>G SLC22A10) associated with sex hormone levels according to genome-wide association studies (GWAS) data was performed. The association of polymorphisms with EH was assessed by regression analysis.

RESULTS

The rs112295236 C>G SLC22A10 polymorphism was associated with EH according to the dominant model (OR 1.74; 95% CI 1.01—3.02; pperm=0.050). The presence of the alternative G variant rs112295236 SLC22A10 (genotypes GG+CG) in a woman’s genotype increases her risk of developing the disease (OR > 1). Using an in silico approach, it was shown that the rs112295236 SLC22A10 variant and 65 strongly linked loci may be functionally significant in relation to five genes: SLC22A24, SLC22A25 (epigenetic modifications), SLC22A9, ATL3 (expression), and SLC22A10 (epigenetic modifications and expression).

CONCLUSION

The rs112295236 C>G polymorphism in SLC22A10 is associated with EH in women with normal body weight, which may be used in the future to diagnose (prognosticate) EH in women with normal body weight.

Keywords:

endometrial hyperplasia
polymorphism
associations

Authors:

Churnosov V.I.

Belgorod State National Research University, Belgorod, Russia

Ponomarenko I.V.

Belgorod State National Research University, Belgorod, Russia

Churnosov M.I.

Belgorod State National Research University, Belgorod, Russia

Received:

08.10.2025

Accepted:

15.10.2025

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