OBJECTIVE

To analyze obstetric and perinatal outcomes in pregnant women with concomitant respiratory diseases who had acute respiratory infections during gestation.

MATERIAL AND METHODS

Sixty pregnant women with bronchial asthma of moderately severe course with acute respiratory infection during gestation were examined and delivered. Retrospectively, they were divided into two groups of 30 patients each: Group 1 consisted of patients who had an acute respiratory infection before 16 weeks of gestation, and Group 2 included pregnant women who became ill at 16—30 weeks of gestation. The comparison group (group 3) consisted of 20 pregnant women with bronchial asthma without acute inflammatory diseases during gestation. General clinical examination, extended study of the hemostasis system, hormones of fetoplacental complex and interferon status, acid-base state of capillary blood, saturation, ultrasound and Doppler parameters in dynamics were investigated.

RESULTS

It was shown that exacerbation of bronchial asthma during pregnancy was significantly more frequent in the main groups: group 1 — in 70%, group 2 — in 53.3%, group 3 — in 30%. This correlated with the frequency of obstetric and perinatal complications. In Group 1, the Apgar score at birth in 43.3% of newborns was less than 8 points, which was 2.6 times more frequent than in Group 2. Fetal growth retardation in group 1 was diagnosed in 30% of children, which was probably associated with the formation of PI of infectious genesis at an earlier gestational age than in group 2.

CONCLUSION

The obtained results indicate a negative effect of acute respiratory infection on the course of pregnancy in patients with respiratory diseases regardless of the severity of acute respiratory infection. This requires clarification of pathogenetic mechanisms of development of these complications and optimization of management of this contingent of patients.