Modern possibilities of predicting premature abruption of the normally located placenta

Lazareva A.Yu.; Fatkullina I.B.

doi:https://doi.org/10.17116/rosakush20232305150

Lazareva A.Yu.

Bashkir State Medical University

ORCID: 0000-0002-8299-0268

Fatkullina I.B.

Bashkir State Medical University

ORCID: 0000-0001-5723-2062

Modern possibilities of predicting premature abruption of the normally located placenta

Authors:

Lazareva A.Yu., Fatkullina I.B.

More about the authors

Journal: Russian Bulletin of Obstetrician-Gynecologist. 2023;23(5): 50‑55

DOI: 10.17116/rosakush20232305150

Read: 1633 times

Download PDF (RU)

Contact the author

Table of contents

To cite this article:

Lazareva AYu, Fatkullina IB. Modern possibilities of predicting premature abruption of the normally located placenta. Russian Bulletin of Obstetrician-Gynecologist. 2023;23(5):50‑55. (In Russ.)
https://doi.org/10.17116/rosakush20232305150

Подписка 2026 Российский вестник акушера-гинеколога (Russian Bulletin of Obstetrician-Gynecologist)

Использование инфографики авторами научных работ

Close metadata

Recommended articles:

Peculiarities of placental microRNA expression in patients with preeclampsia and fetal growth restriction. Russian Bulletin of Obstetrician-Gynecologist. 2024;(6):14-25

On molecular genetic predictors of preeclampsia. Russian Bulletin of Obstetrician-Gynecologist. 2024;(6):26-34

The level of hypoxia-induced factor-1a and associated molecules in preeclampsia. Russian Bulletin of Obstetrician-Gynecologist. 2025;(1):5-10

Modern concepts of preeclampsia, taking into account the role of the permeability of the hematoencephalic barrier. Russian Bulletin of Obstetrician-Gynecologist. 2025;(1):11-18

Modern aspects of gestational diabetes mellitus: definition, risk factors. Russian Bulletin of Obstetrician-Gynecologist. 2025;(2):35-41

Epigenetic regulation in the placenta in case of impaired trophoblast invasion (a review). Russian Journal of Human Reproduction. 2024;(6):45-54

Involvement of medical professionals in the provision of medical care to quit tobacco and nicotine consumption. Russian Journal of Preventive Medicine. 2025;(1):14-23

Effectiveness of using preventive and personalized technologies for obesity correction. Problems of Balneology, Physiotherapy and Exercise Therapy. 2024;(6-2):80-90

Morphological markers of mitochondrial dysfunction of the basal plate cytotrophoblast of the placenta in preeclampsia of varying severity. Russian Journal of Archive of Pathology. 2025;(2):24-29

Molecular mechanisms of preeclampsia. Russian Journal of Human Reproduction. 2025;(2):44-53

Abstract:

Fatal obstetric hemorrhage is an urgent problem of modern obstetrics, as it still occupies leading positions in the structure of maternal mortality. Bleeding associated with premature detachment of the normally located placenta reaches 3% of the population. In addition, premature detachment of the normally located placenta has an unfavorable outcome for both mother and fetus, often leading to disability. Placental abruption is always a sudden and difficult to control situation, so it is important to study the prognostic factors of this pathology to prevent it. The article presents an analytical review of the pathogenetic basis of predictors of premature detachment of the normally located placenta, such as hypertensive disorders, insulin resistance, disorders in the hemostasis system, premature rupture of amnion and chorioamnionitis, and nicotine abuse.

Keywords:

obstetric hemorrhage

premature abruption of normally located placenta

thrombophilia

insulin resistance

pre-eclampsia

chorioamnionitis

nicotine abuse

Authors:

Lazareva A.Yu.

Bashkir State Medical University

ORCID: 0000-0002-8299-0268

Fatkullina I.B.

Bashkir State Medical University

ORCID: 0000-0001-5723-2062

Received:

07.09.2022

Accepted:

05.10.2022

Close metadata

References:

Filippov OS, Guseva EV. Maternal mortality in the Russian Federation in 2019. Problemy reproduktsii. 2020;26:6-2:8-26. (In Russ.). https://doi.org/10.17816/mser50725-29869
Data of the Federal State Statistics Service: electronic resource. (In Russ.). https://rosstat.gov.ru
WHO recommendations for antenatal care for a positive pregnancy experience. Zheneva: Vsemirnaya organizatsiya zdravookhraneniya. 2017 g. (In Russ.).
Obstetrics. National guide. Ed. Ailamazyan E.K., Serov V.N., Radzinskii V.E., Savel’eva G.M. M.: GEOTAR-Media. 2021;608.
Obstetrics. National guide. Ed. Savel’eva G.M., Sukhikh G.T., Serov V.N., Radzinskii V.E. M.: GEOTAR-Media. 2021;608. (In Russ.).
Radzinskii V.E., Fuks A.M. Obstetrics. M.: GEOTAR-Media. 2019;1080. (In Russ.).
Preeclampsia. Eclampsia. Edema, proteinuria and hypertensive disorders during pregnancy, childbirth and the postpartum period: ROAG clinical guidelines. 2021g. (In Russ.).
Guedes-Martins L. Chronic hypertension and pregnancy. Adv Exp Med Biol. 2017;956:395-407. https://doi.org/10.1007/5584_2016_81
Diagnosis and treatment of cardiovascular diseases during pregnancy 2018. National guidelines. Rossiiskii kardiologicheskii zhurnal. 2018;155:3: 91-134. (In Russ.). https://doi.org/10.15829/1560-4071-2018-3-91-134
Sizova OV, Rad’kov OV, Kolbasnikov SV, Paramonova EK. Chronic hypertension in pregnant women: prognosis and prevention of pregnancy complications; antihypertensive therapy policy. Rossiiskii vestnik akushera-ginekologa. 2018;18;6:25-30. (In Russ.). https://doi.org/10.17116/rosakush20181806125
Ambia AM, Morgan JL, Wells CE, Roberts SW, Sanghavi M, Nelson DB, Cunningham FG. Perinatal outcomes associated with abnormal cardiac remodeling in women with treated chronic hypertension. Am J Obstet Gynecol. 2018;218:5:519-526. https://doi.org/10.1016/j.ajog.2018.02.015
Ambia AM, Morgan JL, Wilson KL, Roberts SW, Wells CE, McIntire DD, Sanghavi M, Nelson DB, Cunningham FG. Frequency and consequences of ventricular hypertrophy in pregnant women with treated chronic hypertension. Am J Obstet Gynecol. 2017; 217:4:467.e1-e467.e6. https://doi.org/10.1016/j.ajog.2017.05.061
Khodzhaeva ZS, Kholin AB, Chulkov VS, Muminova KT. Acetylsalicylic acid in the prevention of preeclampsia and associated obstetric and perinatal complications. Akusherstvo i ginekologiya. 2018;8:12-18. (In Russ.). https://doi.org/10.18565/aig.2018.8.12-18
Baranovskaya EI. Preeclampsia in modern conditions. Akusherstvo i ginekologiya. 2018;11:5-9. (In Russ.). https://doi.org/10.18565/aig.2018.11.5-9
Syundyukova EG, Chulkov VS, Ryabikina MG. Preeclampsia: the current state of the problem. Doktor.Ru. 2021;20:1:11-16. (In Russ.).
Regitz-Zagrosek V, Roos-Hesselink JW, Bauersachs J. Blomström-Lundqvist C, Cífková R, De Bonis M, Iung B, Johnson MR, Kintscher U, Kranke P, Lang IM, Morais J, Pieper PG, Presbitero P, Price S, Rosano GMC, Seeland U, Simoncini T, Swan L, Warnes CA. 2018 ESC guidelines for the management of cardiovascular diseases during pregnancy. Eur Heart J. 2018;39:34:3165-3241. https://doi.org/10.1093/eurheartj/ehy340
Burton GJ, Redman CW, Roberts JM, Moffett A. Pre-eclampsia: pathophysiology and clinical implications. BMJ. 2019;366:l2381. https://doi.org/10.1136/bmj.l2381
Kaptil’nyi VA, Reishtat DYu. Preeclampsia: a new definition in pathogenesis, guidelines, treatment and prevention. Arkhiv akusherstva i ginekologii im. V.F. Snegireva. 2020;7:1:19-30. (In Russ.). https://doi.org/10.18821/2313-8726-2020-7-1-19-30
Grigor’eva KN, Bitsadze VO, Khizroeva DKh, Tret’yakova MV, Blinov DV, Makatsariya NA, Tsibizova VI, Nakaidze IA, Gashimova NR, Grandone E, Makatsariya AD. Metalloproteinases as biochemical markers of pregnancy pathology. Akusherstvo, ginekologiya i reproduktsiya. 2022;16:1:38-47. (In Russ.). https://doi.org/10.17749/2313-7347/ob.gyn.rep.2022.275
Laskowska M. Altered maternal serum matrix metalloproteinases MMP-2, MMP-3, MMP-9, and MMP-13 in severe early- and late-onset preeclampsia. BioMed Res Int. 2017:2017:6432426. https://doi.org/10.1155/2017/6432426
Yakovleva NYu, Vasil’eva EYu, Kuznetsova LV, Shelepova ES, Khazova EL, Repinskaya EA. The content of matrix metalloproteinase-12 during pregnancy complicated by preeclampsia. Zhurnal akusherstva i zhenskikh boleznei. 2017;66:6:66-72. (In Russ.). https://doi.org/10.17816/JOWD66666-72
Papysheva OV, Kotaish GA, Orazmuradov AA, Arakelyan GA, Savenkova IV. Complications of pregnancy in women with metabolic syndrome. Akusherstvo i ginekologiya: novosti, mneniya, obuchenie. 2018;6:3:Prilozhenie:18-22. (In Russ.). https://doi.org/10.24411/2303-9698-2018-13902
Ornaghi S, Algeri P, Todyrenchuk L. Vertemati E, Vergani P. Impact of excessive pre-pregnancy body mass index and abnormal gestational weight gain on pregnancy outcomes in women with chronic hypertension. Pregnancy Hypertens. 2018;12:90-95. https://doi.org/10.1016/j.preghy.2018.04.005
Non-progressive pregnancy: MARS (Interdisciplinary Association of Reproductive Medicine) guidelines). Ed. Radzinskii V.E. M.: Redaktsiya zhurnala StatusPraesens. 2015;48. (In Russ.).
Pashentseva AV, Verbovoi AF, Sharonova LA. Insulin resistance in a therapeutic clinic. Ozhirenie i metabolizm. 2017;14:2:9-17. (In Russ.). https://doi.org/10.14341/OMET201729-17
Kastueva ND, Tsidaeva TI, Belikova ZF, Maisuradze LV. Pathogenetic aspects of the metabolic syndrome in women of reproductive age (literature review). Kubanskii nauchnyi meditsinskii vestnik. 2019;26:2:162-172. (In Russ.). https://doi.org/10.25207/1608-6228-2019-26-2-162-172
Bashmakova NV, Tret’yakova TB, Frolukhina OB, Deryabina EG. Gestational diabetes mellitus — genetic aspects. Problemy reproduktsii. 2019;25:6:22-28. (In Russ.). https://doi.org/10.17116/repro20192506122
High risk pregnancy. Ed. Makatsariya A.D., Chervenak F.A., Bitsadze V.O. Izdatel’stvo: Meditsinskoe informatsionnoe agentstvo; 2015. (In Russ.).
Pasman NM, Chumanova OV. The significance of thrombophilia in the development of premature detachment of a normally located placenta. Akusherstvo, ginekologiya i reproduktsiya. 2019;13:1:29-34. (In Russ.). https://doi.org/10.17749/2313-7347.2019.13.1.029-034
Bolotskikh VM, Borisova VYu, Afanas’eva MKh. Premature rupture of amniotic fluid: problems of diagnosis and labor induction. Zhurnal akusherstva i zhenskikh boleznei. 2015;64:2:19-23. (In Russ.).
Minna Tikkanen. Placental abruption: epidemiology, risk factors and consequences. Acta Obstetricia et Gynecologica Scand. 2011;90:140-149. https://doi.org/10.1111/j.1600-0412.2010.01030.x
Chursina OA, Konstantinova OD, Sennikova ZhV, Demina LM, Loginova EA. The influence of active and passive smoking on the course of pregnancy and childbirth. Rossiiskii vestnik akushera-ginekologa. 2019;19:4:47-52. (In Russ.). https://doi.org/10.17116/rosakush20191904147
Meyer MB, Jonas BS, Tonascia JA. Perinatal events associated with maternal smoking during pregnancy. Am J Epidemiol. 1976;103:464-476.