The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Zaidieva Ya.Z.

Moscow Regional Research Institute of Obstetrics and Gynecology

Kazantseva V.D.

Moscow Regional Research Institute of Obstetrics and Gynecology

Polycystic ovary syndrome in middle-aged women: associated diseases

Authors:

Zaidieva Ya.Z., Kazantseva V.D.

More about the authors

Journal: Russian Bulletin of Obstetrician-Gynecologist. 2022;22(1): 45‑51

DOI: 10.17116/rosakush20222201145

Views: 1720

Downloaded: 85

Download PDF (RU)
Contact the author
Table of contents

POLYCYSTIC OVARY SYNDROME IN MIDDLE-AGED WOMEN: ASSOCIATED DISEASES
POLYCYSTIC OVARY SYNDROME IN MIDDLE-AGED WOMEN: ASSOCIATED DISEASES

To cite this article:

Zaidieva YaZ, Kazantseva VD. Polycystic ovary syndrome in middle-aged women: associated diseases. Russian Bulletin of Obstetrician-Gynecologist. 2022;22(1):45‑51. (In Russ.)
https://doi.org/10.17116/rosakush20222201145

Подписка 2025-2 (Russian Bulletin of Obstetrician-Gynecologist)
 
МСФ на ЯМ
Close metadata
Recommended articles:
Predictors of effe­ctive complex physiotherapy in patients with skin invo­lution. Rege­nerative Biotechnologies, Preventive, Digi­tal and Predictive Medi­cine. 2024;(1):13-20
Influence of inte­stinal microbiota on cardiovascular athe­rosclerotic diseases and colo­rectal cancer in elde­rly patients. Rege­nerative Biotechnologies, Preventive, Digi­tal and Predictive Medi­cine. 2024;(1):30-36
Long-term follow-up of a patient with disseminated endo­metrial adenocarcinoma and cere­bral meta­stases. P.A. Herzen Journal of Onco­logy. 2024;(3):63-67
Targeting NMDAR/AMPAR: a promising pharmacotherapeutic approach for depressive diso­rders. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(5):22-30
Asthenia in young patients and possibilities for its correction. S.S. Korsakov Journal of Neurology and Psychiatry. 2024;(5):133-137
Serum uric acid — a meta­bolic marker of non-alcoholic fatty liver disease. Russian Journal of Evidence-Based Gastroenterology. 2024;(2):36-42
Dyna­mics of outpatient glycemic profile data in patients with type 2 diabetes receiving dietary fiber. Russian Journal of Evidence-Based Gastroenterology. 2024;(2):55-65
Asse­ssment of the condition of organs and tissues of the oral cavity in people with dentition defe­cts against the background of meta­bolic syndrome. Stomatology. 2024;(3):31-38
Patients with ischaemic heart disease and non-steroidal anti-inflammatory drugs dosing — reco­mmendations and real-life clinical setting. Russian Journal of Preventive Medi­cine. 2024;(6):68-73
Pathophysiological mechanisms of vascular wall alte­rations in meno­pausal women. Russian Journal of Preventive Medi­cine. 2024;(6):91-97

Polycystic ovary syndrome (PCOS) is one of the most common diseases in endocrinological gynecology. Its etiology remains unclear. Clinical symptoms of PCOS include amenorrhea or oligo-menorrhea, hirsutism, acne, infertility that usually determine the main treatment directions. Nevertheless, the impact of PCOS on the future risk of cardiovascular diseases (CVD) and their prevention in middle-aged women should not be overlooked. The pathogenesis of PCOS usually involves insulin resistance that leads to a range of cardiologic metabolic disorders (dyslipidemia, hypertension, impaired glucose tolerance, type 2 diabetes, and metabolic syndrome), thereby placing women at increased risk of CVD development. In addition, PCOS is associated with depression and cancers of reproductive system in middle-aged women.

Keywords:

polycystic ovary syndrome
metabolic syndrome
type 2 diabetes mellitus
cardiovascular diseases
depression
endometrial cancer

Authors:

Zaidieva Ya.Z.

Moscow Regional Research Institute of Obstetrics and Gynecology

Kazantseva V.D.

Moscow Regional Research Institute of Obstetrics and Gynecology

Received:

02.02.2021

Accepted:

03.03.2021

List of references:

  1. Dapas M, Sisk R, Legro RS, Urbanek M, Dunaif A, Hayes MG. Family-based quantitative trait meta-analysis implicates rare noncoding variants in DENND1A in polycystic ovary syndrome [published online ahead of print, 2019 Apr 30]. J Clin Endocrinol Metab. 2019;104:9:3835-3850. https://doi.org/10.1210/jc.2018-02496
  2. Goodarzi MO, Dumesic DA, Chazenbalk G, Azziz R. Polycystic ovary syndrome: etiology, pathogenesis and diagnosis. Nat Rev Endocrinol. 2011;7:4:219-231. 
  3. Teede HJ, Misso ML, Costello MF, Dokras A, Laven J, Moran L, Piltonen T, Norman RJ. Recommendation from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome. Fertility and Sterility. 2018;110:3:364-379. 
  4. Conway G, Dewailly D, Diamanti-Kandarakis E. The polycystic ovary syndrome: a position statement from the European Society of Endocrinology. Eur J Endocrinol. 2014;171:1-29. 
  5. Sirmans SM, Parish RC, Blake S, Wang X. Epidemiology and comorbidities of polycystic ovary syndrome in an indigent population. J Investig Med. 2014;62:6:868-874.  https://doi.org/10.1097/01.JIM.0000446834.90599.5d
  6. Hart R, Doherty DA. The potential implications of a PCOS diagnosis on a woman’s long-term health using data linkage [published correction appears in J Clin Endocrinol Metab. 2015;100(6):2502]. J Clin Endocrinol Metab. 2015;100:3:911-919.  https://doi.org/10.1210/jc.2014-3886
  7. Cheung LP, Ma RCW, Lam PM, Lok. IH. Cardiovascular risks and metabolic syndrome in Hong Kong Chinese women with polycystic ovary syndrome. Hum Reprod. 2008;23:6:1431-1438. https://doi.org/10.1093/humrep/den090
  8. Cussons AJ, Watts GF, Burke V, Shaw JE, Zimmet PZ, Stuckey BG. Cardiometabolic risk in polycystic ovary syndrome: a comparison of different approaches to defining the metabolic syndrome. Hum Reprod. 2008;23:10:2352-2358. https://doi.org/10.1093/humrep/den263
  9. Mani H, Levy MJ, Davies MJ, Morris DH, Gray LJ, Bankart J, Blackledge H, Khunti K, Howlett TA. Diabetes and cardiovascular events in women with polycystic ovary syndrome: a 20-year retrospective cohort study. Clin Endocrinol (Oxf). 2013;78:6:926-934.  https://doi.org/10.1111/cen.12068
  10. Calderon-Margalit R, Siscovick D, Merkin SS, Wang E, Daviglus ML, Schreiner PJ, Sternfeld B, Williams OD, Lewis CE, Azziz R, Schwartz SM, Wellons MF. Prospective association of polycystic ovary syndrome with coronary artery calcification and carotid-intima-media thickness: the Coronary Artery Risk Development in Young Adults Women’s study. Arterioscler Thromb Vasc Biol. 2014;34:12:2688-2694. https://doi.org/10.1161/ATVBAHA.114.304136
  11. Dokras A, Clifton S, Futterweit W, Wild R. Increased risk for abnormal depression scores in women with polycystic ovary syndrome: a systematic review and meta-analysis. Obstet Gynecol. 2011;117:1:145-152.  https://doi.org/10.1097/AOG.0b013e318202b0a4
  12. Shen CC, Yang AC, Hung JH, Hu LY, Tsai SJ. A nationwide population-based retrospective cohort study of the risk of uterine, ovarian and breast cancer in women with polycystic ovary syndrome. Oncologist. 2015;20:1:45-49.  https://doi.org/10.1634/theoncologist.2014-0311
  13. Barry JA, Azizia MM, Hardiman PJ. Risk of endometrial, ovarian and breast cancer in women with polycystic ovary syndrome: a systematic review and meta-analysis. Hum Reprod Update. 2014;20:5:748-758.  https://doi.org/10.1093/humupd/dmu012
  14. Gottschau M, Kjaer SK, Jensen A, Munk C, Mellemkjaer L. Risk of cancer among women with polycystic ovary syndrome: a Danish cohort study. Gynecol Oncol. 2015;136;1:99-103.  https://doi.org/10.1016/j.ygyno.2014.11.012
  15. Iftikhar S, Collazo-Clavell ML, Roger VL, Sauver JSt, Brown RD Jr, Cha S, Rhodes DJ. Risk of cardiovascular events in patients with polycystic ovary syndrome. Neth J Med. 2012;70:2:74-80. 
  16. Anderson SA, Barry JA, Hardiman PJ. Risk of coronary heart disease and risk of stroke in women with polycystic ovary syndrome: a systematic review and meta-analysis. Int J Cardiol. 2014;176:2:486-487.  https://doi.org/10.1016/j.ijcard.2014.06.079
  17. Zhou Y, Wang X, Jiang Y, Ma H, Chen L, Lai C, Peng C, He C, Sun C. Association between polycystic ovary syndrome and the risk of stroke and all-cause mortality: insights from a meta-analysis. Gynecol Endocrinol. 2017;33:12:904-910.  https://doi.org/10.1080/09513590.2017.1347779
  18. Cassar S, Teede HJ, Harrison CL, Joham AE, Moran LJ, Stepto NK. Biomarkers and insulin sensitivity in women with Polycystic Ovary Syndrome: Characteristics and predictive capacity. Clin Endocrinol (Oxf). 2015;83:1:50-58.  https://doi.org/10.1111/cen.12619
  19. Moran LJ, Noakes M, Wittert GA, Clifton PM, Norman RJ. Weight loss and vascular inflammatory markers in overweight women with and without polycystic ovary syndrome. Reprod Biomed Online. 2012;25:5:500-503.  https://doi.org/10.1016/j.rbmo.2012.07.013
  20. Ali AT. Polycystic ovary syndrome and metabolic syndrome. Ceska Gynekol. 2015;80:4:279-289. 
  21. Carmina E, Bucchieri S, Esposito A, Del Puente A, Mansueto P, Orio F, Di Fede G, Rini G. Abdominal fat quantity and distribution in women with polycystic ovary syndrome and extent of its relation to insulin resistance. J Clin Endocrinol Metab. 2007;92:7:2500-2505. https://doi.org/10.1210/jc.2006-2725
  22. Khot UN, Khot MB, Bajzer CT, Sapp SK, Ohman EM, Brener SJ, Ellis SG, Lincoff AM, Topol EJ. Prevalence of conventional risk factors in patients with coronary heart disease. JAMA. 2003;290:7:898-904.  https://doi.org/10.1001/jama.290.7.898
  23. Peppa M, Koliaki C, Papaefstathiou A, Garoflos E, Katsilambros N, Raptis SA, Hadjidakis DI, Dimitriadis GD. Body composition determinants of metabolic phenotypes of obesity in nonobese and obese postmenopausal women. Obesity (Silver Spring). 2013;21:9:1807-1814. https://doi.org/10.1002/oby.20227
  24. Diamanti-Kandarakis E, Papavassiliou AG, Kandarakis SA, Chrousos GP. Pathophysiology and types of dyslipidemia in PCOS. Trends Endocrinol Metab. 2007;18:7:280-285.  https://doi.org/10.1016/j.tem.2007.07.004
  25. Panidis D, Macut D, Tziomalos K, Papadakis E. Prevalence of metabolic syndrome in women with polycystic ovary syndrome. Clin Endocrinol (Oxf). 2013;78:4:586-592.  https://doi.org/10.1111/cen.12008
  26. Hillman JK, Johnson LN, Limaye M, Feldman RA, Sammel M, Dokras A. Black women with polycystic ovary syndrome (PCOS) have increased risk for metabolic syndrome and cardiovascular disease compared with white women with PCOS [corrected] [published correction appears in Fertil Steril. 2014;101(6):1791]. Fertil Steril. 2014;101:2:530-535.  https://doi.org/10.1016/j.fertnstert.2013.10.055
  27. Vrbikova J, Fanta M, Cibula D, Vondra K, Bendlova B. Impaired glucose metabolism in women with polycystic ovary syndrome. Gynecol Obstet Invest. 2009;68:3:186-190.  https://doi.org/10.1159/000232574
  28. Zadhoush F, Sadeghi M, Pourfarzam M. Biochemical changes in blood of type 2 diabetes with and without metabolic syndrome and their association with metabolic syndrome components. J Res Med Sci. 2015;20:8:763-770.  https://doi.org/10.4103/1735-1995.168383
  29. Van Gaal LF, Mertens IL, De Block CE. Mechanisms linking obesity with cardiovascular disease. Nature. 2006;444:7121:875-880.  https://doi.org/10.1038/nature05487
  30. Orio F Jr, Palomba S, Cascella T, Di Biase S, Manguso F, Tauchmanovà L, Nardo LG, Labella D, Savastano S, Russo T, Zullo F, Colao A, Lombardi G. The increase of leukocytes as a new putative marker of low-grade chronic inflammation and early cardiovascular risk in polycystic ovary syndrome. J Clin Endocrinol Metab. 2005;90:1:2-5.  https://doi.org/10.1210/jc.2004-0628
  31. Boorsma W, Snijder MB, Nijpels G, Guidone C, Favuzzi AMR, Mingrone G, Kostense PJ, Heine RJ, Dekker JM. Body composition, insulin sensitivity, and cardiovascular disease profile in healthy Europeans. Obesity (Silver Spring). 2008;16:12:2696-2701. https://doi.org/10.1038/oby.2008.433
  32. Desai V, Prasad NR, Manohar SM, Sachan A, Narasimha SR, Bitla AR. Oxidative stress in non-obese women with polycystic ovarian syndrome. J Clin Diagn Res. 2014;8:7:CC01-CC3.  https://doi.org/10.7860/JCDR/2014/8125.4530
  33. Moran LJ, Misso ML, Wild RA, Norman RJ. Impaired glucose tolerance, type 2 diabetes and metabolic syndrome in polycystic ovary syndrome: a systematic review and meta-analysis. Hum Reprod Update. 2010;16:4:347-363.  https://doi.org/10.1093/humupd/dmq001
  34. Legro RS, Gnatuk CL, Kunselman AR, Dunaif A. Changes in glucose tolerance over time in women with polycystic ovary syndrome: a controlled study. J Clin Endocrinol Metab. 2005;90:6:3236-3242. https://doi.org/10.1210/jc.2004-1843
  35. Legro RS, Kunselman AR, Dodson WC, Dunaif A. Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: a prospective, controlled study in 254 affected women. J Clin Endocrinol Metab. 1999;84:1:165-169.  https://doi.org/10.1210/jcem.84.1.5393
  36. Ehrmann DA, Barnes RB, Rosenfield RL, Cavaghan MK, Imperial J. Prevalence of impaired glucose tolerance and diabetes in women with polycystic ovary syndrome. Diabetes Care. 1999;22:1:141-146.  https://doi.org/10.2337/diacare.22.1.141
  37. Glintborg D, Rubin KH, Nybo M, Abrahamsen B, Andersen M. Cardiovascular disease in a nationwide population of Danish women with polycystic ovary syndrome. Cardiovasc Diabetol. 2018;17:1:37. Published 2018 Mar 8.  https://doi.org/10.1186/s12933-018-0680-5
  38. Meyer ML, Malek AM, Wild RA, Korytkowski MT, Talbott EO. Carotid artery intima-media thickness in polycystic ovary syndrome: a systematic review and meta-analysis. Hum Reprod Update. 2012;18:2:112-126.  https://doi.org/10.1093/humupd/dmr046
  39. Allameh Z, Rouholamin S, Adibi A, Mehdipour M, Adeli M. Does Carotid Intima-media Thickness have Relationship with Polycystic Ovary Syndrome? Int J Prev Med. 2013;4:11:1266-1270.
  40. Marchesan LB, Spritzer PM. ACC/AHA 2017 definition of high blood pressure: implications for women with polycystic ovary syndrome. Fertil Steril. 2019;111:3:579-587.e1.  https://doi.org/10.1016/j.fertnstert.2018.11.034
  41. Joham AE, Boyle JA, Zoungas S, Teede HJ. Hypertension in reproductive-aged women with polycystic ovary syndrome and association with obesity. Am J Hypertens. 2015;28:7:847-851.  https://doi.org/10.1093/ajh/hpu251
  42. Cascella T, Palomba S, Tauchmanovà L, Manguso F, Di Biase S, Labella D, Giallauria F, Vigorito C, Colao A, Lombardi G, Orio F. Serum aldosterone concentration and cardiovascular risk in women with polycystic ovarian syndrome. J Clin Endocrinol Metab. 2006;91:11:4395-4400. https://doi.org/10.1210/jc.2006-0399
  43. Fearnley EJ, Marquart L, Spurdle AB, Weinstein P, Webb PM; Australian Ovarian Cancer Study Group and Australian National Endometrial Cancer Study Group. Polycystic ovary syndrome increases the risk of endometrial cancer in women aged less than 50 years: an Australian case-control study. Cancer Causes Control. 2010;21:12:2303-2308. https://doi.org/10.1007/s10552-010-9658-7
  44. Brinton LA, Moghissi KS, Westhoff CL, Lamb EJ, Scoccia B. Cancer risk among infertile women with androgen excess or menstrual disorders (including polycystic ovary syndrome). Fertil Steril. 2010;94:5:1787-1792. https://doi.org/10.1016/j.fertnstert.2009.10.012
  45. Klaunig JE, Wang Z, Pu X, Zhou S. Oxidative stress and oxidative damage in chemical carcinogenesis. Toxicol Appl Pharmacol. 2011;254:2:86-99.  https://doi.org/10.1016/j.taap.2009.11.028
  46. Giudice LC. Endometrium in PCOS: Implantation and predisposition to endocrine CA. Best Pract Res Clin Endocrinol Metab. 2006;20:2:235-244.  https://doi.org/10.1016/j.beem.2006.03.005
  47. Zuo T, Zhu M, Xu W. Roles of Oxidative Stress in Polycystic Ovary Syndrome and Cancers. Oxid Med Cell Longev. 2016;2016:8589318. https://doi.org/10.1155/2016/8589318
  48. Asmat U, Abad K, Ismail K. Diabetes mellitus and oxidative stress-A concise review. Saudi Pharm J. 2016;24:5:547-553.  https://doi.org/10.1016/j.jsps.2015.03.013
  49. Dokras A, Clifton S, Futterweit W, Wild R. Increased prevalence of anxiety symptoms in women with polycystic ovary syndrome: systematic review and meta-analysis. Fertil Steril. 2012;97:1:225-230.e2.  https://doi.org/10.1016/j.fertnstert.2011.10.022
  50. Lanzo E, Monge M, Trent M. Diagnosis and management of polycystic ovary syndrome in adolescent girls. Pediatr Ann. 2015;44:9:223-230.  https://doi.org/10.3928/00904481-20150910-10
  51. Hahn S, Janssen OE, Tan S, Pleger K, Mann K, Schedlowski M, Kimmig R, Benson S, Balamitsa E, Elsenbruch S. Clinical and psychological correlates of quality-of-life in polycystic ovary syndrome. Eur J Endocrinol. 2005;153:6:853-860.  https://doi.org/10.1530/eje.1.02024
  52. Mezuk B, Eaton WW, Albrecht S, Golden SH. Depression and type 2 diabetes over the lifespan: a meta-analysis. Diabetes Care. 2008;31:12:2383-2390. https://doi.org/10.2337/dc08-0985
  53. Kuchenbecker WKH, Groen H, van Asselt SJ, Bolster JHT, Zwerver J, Slart RHJ, Jagt EJ Vd, Kobold ACM, Wolffenbuttel BHR, Land JA, Hoek A. In women with polycystic ovary syndrome and obesity, loss of intra-abdominal fat is associated with resumption of ovulation. Hum Reprod. 2011;26:9:2505-2512. https://doi.org/10.1093/humrep/der229
  54. Haqq L, McFarlane J, Dieberg G, Smart N. Effect of lifestyle intervention on the reproductive endocrine profile in women with polycystic ovarian syndrome: a systematic review and meta-analysis. Endocr Connect. 2014;3:1:36-46.  https://doi.org/10.1530/EC-14-0010
  55. Cascella T, Palomba S, De Sio I, Manguso F, Giallauria F, De Simone B, Tafuri D, Lombardi G, Colao A, Orio F. Visceral fat is associated with cardiovascular risk in women with polycystic ovary syndrome. Hum Reprod. 2008;23:1:153-159.  https://doi.org/10.1093/humrep/dem356
  56. Karabulut A, Yaylali GF, Demirlenk S, Sevket O, Acun A. Evaluation of body fat distribution in PCOS and its association with carotid atherosclerosis and insulin resistance. Gynecol Endocrinol. 2012;28:2:111-114.  https://doi.org/10.3109/09513590.2011.589929
  57. Kaya C, Pabuccu R, Berker B, Satiroglu H. Plasma interleukin-18 levels are increased in the polycystic ovary syndrome: relationship of carotid intima-media wall thickness and cardiovascular risk factors. Fertil Steril. 2010;93:4:1200-1207. https://doi.org/10.1016/j.fertnstert.2008.10.070
  58. McCook JG, Bailey BA, Williams SL, Anand S, Reame NE. Differential Contributions of Polycystic Ovary Syndrome (PCOS) Manifestations to psychological symptoms. J Behav Health Serv Res. 2015;42:3:383-394.  https://doi.org/10.1007/s11414-013-9382-7
  59. Ali AT, Guidozzi F. Midlife women’s health consequences associated with polycystic ovary syndrome. Climacteric. 2020;23:2:116-122.  https://doi.org/10.1080/13697137.2019.1679111
  60. Osibogun O, Ogunmoroti O, Michos ED. Polycystic ovary syndrome and cardiometabolic risk: Opportunities for cardiovascular disease prevention. Trends Cardiovasc Med. 2020;30:7:399-404.  https://doi.org/10.1016/j.tcm.2019.08.010

Close metadata

Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.