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Gumanova N.G.

National Medical Research Center for Therapy and Preventive Medicine

The significance of exogenous nitrate and nitrite of plant origin for vascular health

Authors:

Gumanova N.G.

More about the authors

Journal: Russian Journal of Preventive Medicine. 2024;27(11): 141‑146

DOI: 10.17116/profmed202427111141

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THE SIGNIFICANCE OF EXOGENOUS NITRATE AND NITRITE OF PLANT ORIGIN FOR VASCULAR HEALTH
THE SIGNIFICANCE OF EXOGENOUS NITRATE AND NITRITE OF PLANT ORIGIN FOR VASCULAR HEALTH

To cite this article:

Gumanova NG. The significance of exogenous nitrate and nitrite of plant origin for vascular health. Russian Journal of Preventive Medicine. 2024;27(11):141‑146. (In Russ.)
https://doi.org/10.17116/profmed202427111141

 
Подписка 2025-2 (Russian Journal of Preventive Medicine)
 
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Phytogenic nitrates and nitrites are important bioactive phytochemical substances with cardioprotective features. Nitrates can be reduced to nitrite (with the active participation of oral bacteria and the stomach acid medium) and then to bioaccessible nitrogen oxide (NO), which plays a key role in the cardiovascular system condition.

OBJECTIVE

To highlight the role of phytogenic nitrates as an NO source in terms of cardiovascular effects.

MATERIAL AND METHODS

The PubMed and eLibrary (Science Index) databases were analyzed using the keywords «exogenous nitrate», «endothelial dysfunction», «vascular wall rigidity», «arterial hypertension», and «blood pressure».

RESULTS

A clinical trial showed food nitrate has an effect equivalent to the endogenous nitrogen oxide. Exogenous nitrate reduces the arterial blood pressure, vascular wall rigidity, and platelet aggregation, improves vascular functional activity, and increases blood flow velocity. The review considers the effectiveness of exogenous phytogenic nitrates regarding the specified parameters.

CONCLUSION

Considering the known transformation pathway «nitrate — nitrite — NO», phytogenic nitrate serves as a substrate for bioactive NO synthesis and has a beneficial effect on vascular health, as confirmed by many clinical trials. Supplementing the diet with nitrate-rich vegetables can be a new approach to reducing the risk of cardiovascular diseases and mortality.

Keywords:

exogenous nitrate
vegetable diet
nitrogen oxide
vascular condition
cardiovascular diseases
endothelial dysfunction vascular wall rigidity
arterial hypertension
blood pressure

Authors:

Gumanova N.G.

National Medical Research Center for Therapy and Preventive Medicine

Received:

26.08.2024

Accepted:

16.09.2024

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