Efficiency and safety of tocolytic therapy with hexoprenaline depending on body mass index in pregnant women

Gureeva L.V.

Tver State Medical University

Chistyakova O.M.

Tver State Medical University

Grebenshchikova L.Yu.

Tver State Medical University

Kolbasnikov S.V.

Tver State Medical University

Rad’kov O.V.

Tver State Medical University

Efficiency and safety of tocolytic therapy with hexoprenaline depending on body mass index in pregnant women

Authors:

Gureeva L.V., Chistyakova O.M., Grebenshchikova L.Yu., Kolbasnikov S.V., Rad’kov O.V.

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Journal: Russian Bulletin of Obstetrician-Gynecologist. 2021;21(4): 75‑80

DOI: 10.17116/rosakush20212104175

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To cite this article:

Gureeva LV, Chistyakova OM, Grebenshchikova LYu, Kolbasnikov SV, Rad’kov OV. Efficiency and safety of tocolytic therapy with hexoprenaline depending on body mass index in pregnant women. Russian Bulletin of Obstetrician-Gynecologist. 2021;21(4):75‑80. (In Russ.)
https://doi.org/10.17116/rosakush20212104175

Подписка 2025-2 (Russian Bulletin of Obstetrician-Gynecologist)

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OBJECTIVE

To evaluate the efficacy and safety of the tocolysis with hexoprenaline application in pregnant women depending on the body mass index (BMI).

MATERIAL AND METHODS

Patients with threatened preterm childbirth who received hexoprenaline for tocolysis were divided into two groups: non-obese (n=71, group 1) and obese (n=53, group 2). The analysis of efficiency indicators, the frequency of adverse effects of tocolysis, Holter ECG monitoring and biochemical assays were performed.

RESULTS

The indicators of the effectiveness of tocolysis with hexoprenaline in the groups did not differ significantly. Adverse effects of tocolysis (nausea and tremor) were significantly more frequent in pregnant women with normal BMI than in obese patients. According to the data of 24-hour ECG monitoring in both groups of patients there was a decrease in the variability of the cardiac rhythm but in obese pregnant women, the vagal effects on the heart rhythm significantly decreased and the frequency of cardiac arrhythmias increased. Among obese patients during tocolysis with hexoprenaline the level of lipid and glucose fractions in the blood was significantly higher than in non-obese pregnant women.

CONCLUSION

The frequency of adverse effects, indicators of regulation of the cardiovascular system and metabolism during tocolysis with hexoprenaline depend on the BMI in pregnant women. When using tocolytic therapy with a beta-adrenomimetic it is necessary to take into consideration the presence or absence of obesity in patient.

Keywords:

premature childbirth

hexoprenaline

obesity

Authors:

Gureeva L.V.

Tver State Medical University

Chistyakova O.M.

Tver State Medical University

Grebenshchikova L.Yu.

Tver State Medical University

Kolbasnikov S.V.

Tver State Medical University

Rad’kov O.V.

Tver State Medical University

Received:

29.09.2020

Accepted:

21.12.2020

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