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Tsirkin V.I.
Viatskiĭ gosudarstvennyĭ gumanitarnyĭ universitet, Kirov;
Kazanskiĭ gosudarstvennyĭ meditsinskiĭ universitet
Trukhina S.I.
Vyatka State University, Kirov, Russia
Trukhin A.N.
Vyatka State University, Kirov, Russia
Khlybova S.V.
Kafedra akusherstva i ginekologii Instituta poslediplomnogo obrazovaniia Kirovskoĭ gosudarstvennoĭ meditsinskoĭ akademii
Anisimov K.Yu.
Department of Obstetrics and Gynecology, Faculty of General Medicine, Ural State Medical University, Yekaterinburg, Russia
Oxytocin receptor antagonists and their clinical application
Journal: Russian Bulletin of Obstetrician-Gynecologist. 2018;18(5): 16‑22
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To cite this article:
Tsirkin VI, Trukhina SI, Trukhin AN, Khlybova SV, Anisimov KYu. Oxytocin receptor antagonists and their clinical application. Russian Bulletin of Obstetrician-Gynecologist.
2018;18(5):16‑22. (In Russ.)
https://doi.org/10.17116/rosakush20181805116
The review concerns a depiction of oxytocin receptor antagonists that can be used to inhibit uterine contractility during preterm labor (PL) and in vitro fertilization (IVF) and to stop the birthing process for the fetus’s interests. There is mostly information about the peptide oxytocin receptor antagonist atosiban that has been approved for use in Europe, the USA, and Russia. The available data suggest that atosiban is effective as a tocolytic in the above obstetric situations and relatively highly safe for the mother and fetus. The review also contains data on oxytocin receptor antagonists (the peptide antagonist barusiban, the non-peptide antagonist of the retosiban type, etc.) that are being put through preclinical tests.
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Authors:
Tsirkin V.I.
Viatskiĭ gosudarstvennyĭ gumanitarnyĭ universitet, Kirov;
Kazanskiĭ gosudarstvennyĭ meditsinskiĭ universitet
Trukhina S.I.
Vyatka State University, Kirov, Russia
Trukhin A.N.
Vyatka State University, Kirov, Russia
Khlybova S.V.
Kafedra akusherstva i ginekologii Instituta poslediplomnogo obrazovaniia Kirovskoĭ gosudarstvennoĭ meditsinskoĭ akademii
Anisimov K.Yu.
Department of Obstetrics and Gynecology, Faculty of General Medicine, Ural State Medical University, Yekaterinburg, Russia
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