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Malyshkina A.I.

V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood;
Ivanovo State Medical University

Sotnikova N.Yu.

V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood;
Ivanovo State Medical University

Kroshkina N.V.

Ivanovo Research Institute of Motherhood and Childhood named after V.N. Gorodkov

Talanova I.E.

V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood;
Ivanovo State Medical University

Kolesnikova A.M.

V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood;
Ivanovo State Medical University

Prediction of preterm labor in women with habitual miscarriage based on the study of the level of proapoptotic factor LIGHT in the serum of pregnant women

Authors:

Malyshkina A.I., Sotnikova N.Yu., Kroshkina N.V., Talanova I.E., Kolesnikova A.M.

More about the authors

Journal: Russian Bulletin of Obstetrician-Gynecologist. 2025;25(3): 11‑18

DOI: 10.17116/rosakush20252503111

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Table of contents

PREDICTION OF PRETERM LABOR IN WOMEN WITH HABITUAL MISCARRIAGE BASED ON THE STUDY OF THE LEVEL OF PROAPOPTOTIC FACTOR LIGHT IN THE SERUM OF PREGNANT WOMEN
PREDICTION OF PRETERM LABOR IN WOMEN WITH HABITUAL MISCARRIAGE BASED ON THE STUDY OF THE LEVEL OF PROAPOPTOTIC FACTOR LIGHT IN THE SERUM OF PREGNANT WOMEN

To cite this article:

Malyshkina AI, Sotnikova NYu, Kroshkina NV, Talanova IE, Kolesnikova AM. Prediction of preterm labor in women with habitual miscarriage based on the study of the level of proapoptotic factor LIGHT in the serum of pregnant women. Russian Bulletin of Obstetrician-Gynecologist. 2025;25(3):11‑18. (In Russ.)
https://doi.org/10.17116/rosakush20252503111

 
Подписка 2026 Российский вестник акушера-гинеколога (Russian Bulletin of Obstetrician-Gynecologist)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To determine the significance of the level of proapoptotic factor concentration LIGHT (homologous to lymphotoxin -beta exhibits inducible expression and competes with HSV glycoprotein D for binding to herpesvirus entry mediator, a receptor expressed on T-lymphocytes — the abbreviation is formed from the first letters of the words, bolded — homologous to lymphotoxin-beta, showing inducing activity, competing with glycoprotein D for binding to herpesvirus entry mediator; receptor expressing T-lymphocytes) in serum from pregnant women with habitual miscarriage and threat of late miscarriage to predict preterm labor.

MATERIAL AND METHODS

Forty-nine pregnant women with habitual miscarriage and threatened late miscarriage were examined, and 30 of them underwent an immunologic study to determine the content of proapoptotic factor LIGHT in serum. Patients in whom LIGHT factor was determined were divided into 2 groups. The main group consisted of 15 patients with habitual miscarriage and threatened late miscarriage, whose pregnancy ended in preterm labor. The comparison group consisted of 15 pregnant women with habitual miscarriage and threatened late miscarriage with term delivery.

RESULTS

It was found that LIGHT concentration in patients of the main group was statistically significantly lower (18.74 [12.11; 26.46] pg/mL) than in pregnant women of the comparison group (70.34 [46.38; 105.82] pg/mL; p=0.001). ROC analysis revealed high diagnostic value of this method: AUC 0.856 (95% CI 0.68-0.96), sensitivity 100.0% (95% CI 78.0—100.0%), specificity 80.0% (95% CI 51.9—95.4%), predictive value of positive result 83.3% (95% CI 81.0—85.6%), predictive value of negative result 100.0% (95% CI 100.0—100.0%).

CONCLUSION

Determination of LIGHT factor concentration in peripheral blood can be considered a promising method for predicting PL in women with habitual miscarriage and threatened late miscarriage.

Keywords:

habitual miscarriage
preterm labor
proapoptotic factor LIGHT

Authors:

Malyshkina A.I.

V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood;
Ivanovo State Medical University

Sotnikova N.Yu.

V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood;
Ivanovo State Medical University

Kroshkina N.V.

Ivanovo Research Institute of Motherhood and Childhood named after V.N. Gorodkov

Talanova I.E.

V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood;
Ivanovo State Medical University

Kolesnikova A.M.

V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood;
Ivanovo State Medical University

Received:

16.12.2024

Accepted:

14.01.2025

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