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Peretiatko L.P.

FGBU "Ivanovskiĭ NII materinstva i detstva im. V.N. Gorodkova" Minzdrava Rossii

Nikiforova N.V.

Department of Obstetrics and Gynecology, Pediatric Faculty, Ivanovo State Medical Academy, Ministry of Health of Russia, Ivanovo, Russia

Kuznetsov R.A.

Laboratory of Pathomorphology and Electron Microscopy, V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood, Ministry of Health of Russia, Ivanovo, Russia

Kerimkulova N.V.

Department of Obstetrics and Gynecology, Pediatric Faculty, Ivanovo State Medical Academy, Ministry of Health of Russia, Ivanovo, Russia

Malyshkina A.I.

FGBU "Ivanovskiĭ NII materinstva i detstva im. V.N. Gorodkova" Minzdrava Rossii

Placental pathomorphology, pregnancy and labor complications, and neonatal outcomes in patients with undifferentiated connective tissue dysplasia

Authors:

Peretiatko L.P., Nikiforova N.V., Kuznetsov R.A., Kerimkulova N.V., Malyshkina A.I.

More about the authors

Journal: Russian Bulletin of Obstetrician-Gynecologist. 2018;18(1): 4‑9

DOI: 10.17116/rosakush20181814-9

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Table of contents

PLACENTAL PATHOMORPHOLOGY, PREGNANCY AND LABOR COMPLICATIONS, AND NEONATAL OUTCOMES IN PATIENTS WITH UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA
PLACENTAL PATHOMORPHOLOGY, PREGNANCY AND LABOR COMPLICATIONS, AND NEONATAL OUTCOMES IN PATIENTS WITH UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA

To cite this article:

Peretiatko LP, Nikiforova NV, Kuznetsov RA, Kerimkulova NV, Malyshkina AI. Placental pathomorphology, pregnancy and labor complications, and neonatal outcomes in patients with undifferentiated connective tissue dysplasia. Russian Bulletin of Obstetrician-Gynecologist. 2018;18(1):4‑9. (In Russ.)
https://doi.org/10.17116/rosakush20181814-9

Подписка 2025-2 (Russian Bulletin of Obstetrician-Gynecologist)
 
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Objective — to investigate structural changes in the villous chorion and fetal vessels of puerperas with undifferentiated connective tissue dysplasia. Subject and methods. Surveys and immunohistochemical examination were used to make a morphological study of placentas and to compare its results in puerperas with undifferentiated connective tissue dysplasia (n=90) confirmed by a set of 6 or more diagnostic signs of the disease and in a control group (n=50). Results. There were general pathological processes and changes, characteristic of undifferentiated connective tissue dysplasia, in the placental fetal vessels, which were caused by impaired connective tissue differentiation and maturation. Neonatal outcomes were analyzed; pregnancy and labor complications were summarized. Conclusion. Fetal connective tissue dysplasia accompanied by an increase in the expression of matrix metalloproteinase-9 and by a decrease of collagen types III and IV is manifested by the formation of umbilical cord vessel abnormalities and by impaired chorionic villous maturation.

Keywords:

placenta
pathomorphology
undifferentiated connective tissue dysplasia
immunohistochemistry
vascular malformation
dissociated disturbance of chorionic villous maturation

Authors:

Peretiatko L.P.

FGBU "Ivanovskiĭ NII materinstva i detstva im. V.N. Gorodkova" Minzdrava Rossii

Nikiforova N.V.

Department of Obstetrics and Gynecology, Pediatric Faculty, Ivanovo State Medical Academy, Ministry of Health of Russia, Ivanovo, Russia

Kuznetsov R.A.

Laboratory of Pathomorphology and Electron Microscopy, V.N. Gorodkov Ivanovo Research Institute of Maternity and Childhood, Ministry of Health of Russia, Ivanovo, Russia

Kerimkulova N.V.

Department of Obstetrics and Gynecology, Pediatric Faculty, Ivanovo State Medical Academy, Ministry of Health of Russia, Ivanovo, Russia

Malyshkina A.I.

FGBU "Ivanovskiĭ NII materinstva i detstva im. V.N. Gorodkova" Minzdrava Rossii

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