Objective: to evaluate of the efficiency of using dydrogesterone, 17-hydroxyprogesterone caproate, and oral and vaginal micronized progesterone as compared to that of cervical suturing in the combination prevention of late pregnancy losses in women with a short cervix. Subjects and methods. Different progesterone formulations were given to 95 women with singleton pregnancy and a cervical length of ≤ 25 mm, including 34 patients with asymptomatic cervical shortening at 15 to 24 weeks of gestation, 61 with threatened late miscarriage or preterm birth at 15—24 weeks, and 10 pregnant women with a cervical length of ≤ 20 mm at 25—32 weeks, by following up the length of the cervix and the course of pregnancy; after 1 week of therapy stitches were applied to the cervix in 15 women of them. Results. The use of vaginal progesterone as part of combination therapy prevents late pregnancy losses in 94.1% of the women with a short cervix. In patients with an asymptomatic short cervix, perinatal outcomes were comparable to those when suturing the cervix, but in the absence of side effects. In women with threatened late miscarriage or preterm delivery, three-component therapy, including vaginal progesterone, indomethacin, and treatment for bacterial vaginosis and subsequent long-term use of vaginal progesterone before 36 weeks, by following up the length of the cervix and the course of pregnancy as compared to those of cervical suturing significantly reduces the risk of preterm birth (RR, -0.01; 0,0001—0.24), the birth of low birth weight infants (RR,-0,044; 0.01—0.96), and contributes to an increase in the latent period until delivery and full-term pregnancy. The marker of therapy efficiency is to increase the length of the cervix by a few mm in the first week with further stabilization. The administration of dydrogesterone and 17-hydroxyprogesterone, and oral progesterone leads to preterm birth in 91.7% of the pregnant women. Conclusion. Vaginal progesterone used as part of combination therapy substantially improves perinatal outcomes in pregnant women with a short cervix compared to those of cervical suturing, whereas dydrogesterone, 17-hydroxyprogesterone, and oral progesterone are ineffective. The authors declare no conflicts of interest.