Objective - to assess the results of laparoscopic extirpation of the uterus as a surgical treatment in morbidly obese patients with benign and malignant diseases of the internal genitalia. Subject and methods. A total of 100 patients with morbid obesity (body mass index (BMI), >35 kg/m2) were hysterectomized at the Department of Endoscopic Surgery, Moscow Regional Research Institute of Obstetrics and Gynecology, in 2012 to 2015. The severity of somatic disease, the volume and duration of surgical treatment and anesthesia, and intra- and postoperative complications were analyzed; the pattern of indications for surgical treatment, the accuracy of preoperative histological diagnosis, and the final results of morphological assessment were defined. Results. Among both the indications for surgical treatment and the results of postoperative morphological assessment, there was a preponderance of cancer of corpus uteri (30 and 41%, respectively); moreover, most cases showed less aggressive forms of the disease. The patients with cancer of the uterine corpus had a considerably higher BMI (52.4±8.7 kg/m2) than those with benign diseases of the internal genitalia (BMI, 46±7 kg/m2). The number of mild and moderate complications was 11%; in this case, wound infections were prevalent. No severe complications were recorded. Conclusion. Laparoscopic extirpation of the uterus in morbidly obese patients is the treatment of choice because of a small number of complications, low trauma rates, and rapid rehabilitation. The authors declare no conflicts of interest.