There is no question that folates play a role in providing normal conception, pregnancy, and fetal and infant development. At the same time, folic acid deficiency is one of the most common manifestations of micronutrient deficiency. Folic acid supplementation during pregravid preparation and pregnancy is recognized to be an important factor of preventing miscarriage, preterm delivery, fetoplacental unit dysfunction, fetal malformations, and birth of premature or low birth weight babies. There are diverse ways to eliminate deficiency of folic acid, which include food fortification with the latter, its incorporation into contraceptives, and its use as a monodrug or a component of vitamin/mineral complexes. Folic acid used in combination with other vitamins and minerals versus alone is the optimal choice during pregnancy and has obvious benefits. The review provides evidence for the administration of folic acid 800 µg as part of vitamin/mineral complexes and highlights the role of other vitamins and minerals in a successful pregnancy outcome. At the moment, there are drugs with structure that, instead of folic acid includes L-methylfolate. In Europe, a comparative, placebo-controlled study, which compared the effects of the use of L-methylfolate and folic acid in folate concentration in plasma and erythrocytes was recently held. These studies suggest that folic acid and methylfolate increase the concentration of folate in the blood at the same level, so it makes no sense to use methylfolate instead of folic acid, which has a broad evidence base.