The clinical and laboratory features were studied in 64 pregnant women with symphysis pubis dysfunction who wore an orthopedic corset in different gestation periods. A traditional approach was applied to 79 pregnant women with the similar pathology. A control group consisted of 30 healthy pregnant women. Ultrasound scanning of the symphysis pubis and estimation of the levels of progesterone, total Ca2+, calcitonin, osteocalcin, ionized calcium, and cytokines in the serum and deoxypyridinoline in the urea were made in all the pregnant women. In the pregnant women with symphysis pubis dysfunction, the clinical picture showed a preponderance of persistent pain in the sacral and symphysis pubis region. There was a reduction in the content of progesterone and total calcium in different gestation periods. In full-term pregnancy, there was an inflammatory reaction in the symphysis pubis region, the manifestation of which was the elevated levels of interleukins. The use of the proposed individual combined orthopedic corset alleviated clinical symptoms and reduced the number of cesarean sections for this pathology.