The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Torshin I.Iu.

Rossiĭskiĭ satellitnyĭ tsentr instituta mikroélementov IuNESKO;
Laboratoriia vychislitel'noĭ i sistemnoĭ biologii VTs RAN im. A.A. Dorodnitsyna

Rudakov K.V.

Rossiĭskiĭ satellitnyĭ tsentr instituta mikroélementov IuNESKO

Tetruashvili N.K.

Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. akad. V.I. Kulakova, Moskva

Gromova O.A.

Rossiĭskiĭ satellitnyĭ tsentr instituta mikroélementov IuNESKO;
Laboratoriia vychislitel'noĭ i sistemnoĭ biologii VTs RAN im. A.A. Dorodnitsyna;
kafedra farmakologii i klinicheskoĭ farmakologii Ivanovskoĭ gosudarstvennoĭ meditsinskoĭ akademii

Magnesium, pyridoxine, and thrombophilia in pregnant women: molecular mechanisms and evidence-based medicine

Authors:

Torshin I.Iu., Rudakov K.V., Tetruashvili N.K., Gromova O.A.

More about the authors

Journal: Russian Bulletin of Obstetrician-Gynecologist. 2010;10(4): 67‑71

Read: 10564 times

Download PDF (RU)
Contact the author
Table of contents

MAGNESIUM, PYRIDOXINE, AND THROMBOPHILIA IN PREGNANT WOMEN: MOLECULAR MECHANISMS AND EVIDENCE-BASED MEDICINE
MAGNESIUM, PYRIDOXINE, AND THROMBOPHILIA IN PREGNANT WOMEN: MOLECULAR MECHANISMS AND EVIDENCE-BASED MEDICINE

To cite this article:

Torshin IIu, Rudakov KV, Tetruashvili NK, Gromova OA. Magnesium, pyridoxine, and thrombophilia in pregnant women: molecular mechanisms and evidence-based medicine. Russian Bulletin of Obstetrician-Gynecologist. 2010;10(4):67‑71. (In Russ.)

Подписка 2026 Российский вестник акушера-гинеколога (Russian Bulletin of Obstetrician-Gynecologist)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
The practice of using medi­cal abortion in the world. Russian Bulletin of Obstetrician-Gynecologist. 2025;(1):19-24
Acute kidney injury during pregnancy with favo­rable obstetric and nephrological outcome. Russian Bulletin of Obstetrician-Gynecologist. 2025;(1):65-70
Asplenia — a new cause of thro­mbosis in pregnant women?. Russian Bulletin of Obstetrician-Gynecologist. 2025;(1):71-76
Modern aspe­cts of gestational diabetes mellitus: defi­nition, risk factors. Russian Bulletin of Obstetrician-Gynecologist. 2025;(2):35-41
Clinical case of primary hype­raldosteronism dete­cted during pregnancy: differential diagnosis, neonatal prognosis. Russian Bulletin of Obstetrician-Gynecologist. 2025;(2):98-104
Diagnosis and treatment of ovarian cancer in pregnancy. Russian Bulletin of Obstetrician-Gynecologist. 2025;(3):27-33
Hormonal contraception methods and multiple scle­rosis. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(1):24-30
Reproductive health of women with hepa­titis C (literature review and own data). Russian Journal of Human Reproduction. 2025;(1):12-20
Diagnostics of hype­rtensive diso­rders in cardio-obstetrics: current state-of-affairs. Russian Journal of Human Reproduction. 2025;(1):63-77
Epidemiological moni­toring of morbidity in pregnant women in the Russian Fede­ration: trends and medi­cal and orga­nizational prerequisites for adju­sting prevention programs at the popu­lation level. Russian Journal of Human Reproduction. 2025;(2):7-16
Abstract:

Magnesium balance is important to maintain normal blood coagulation values. Magnesium and pyridoxine preparations are clinically used to compensate for thrombophilia. Part 1 of the paper considers the effect of magnesium on platelet coagulation and aggregation. Part 2 deals with the molecular mechanisms of action of magnesium on a systemic inflammatory response, atherosclerosis development, connective tissue structure, and vasoconstriction. The authors' positive experience in using Magne B6 in complex therapy in 120 women with miscarriage is given. A control group included 120 patients matched for age, parity, causes and time of pregnancy interruption. The understanding of the mechanisms of action of magnesium on coagulation at the molecular level promotes a more effective management of patients and adequate planning of evidence-based medicine studies of magnesium preparations used in obstetrics and gynecology.

Keywords:

pregnancy
miscarriage
molecular mechanisms of action of magnesium
thrombophophilia
pyridoxine

Authors:

Torshin I.Iu.

Rossiĭskiĭ satellitnyĭ tsentr instituta mikroélementov IuNESKO;
Laboratoriia vychislitel'noĭ i sistemnoĭ biologii VTs RAN im. A.A. Dorodnitsyna

Rudakov K.V.

Rossiĭskiĭ satellitnyĭ tsentr instituta mikroélementov IuNESKO

Tetruashvili N.K.

Nauchnyĭ tsentr akusherstva, ginekologii i perinatologii im. akad. V.I. Kulakova, Moskva

Gromova O.A.

Rossiĭskiĭ satellitnyĭ tsentr instituta mikroélementov IuNESKO;
Laboratoriia vychislitel'noĭ i sistemnoĭ biologii VTs RAN im. A.A. Dorodnitsyna;
kafedra farmakologii i klinicheskoĭ farmakologii Ivanovskoĭ gosudarstvennoĭ meditsinskoĭ akademii

Close metadata

References:

  1. Gromova O.A., Torshin I.Yu., Sukhikh G.T., Rudakov K.V. Molekulyarnye mekhanizmy regulyatsii magniem platsentarnykh belkov. Ros vestn akush-gin 2008; 8: 6: 9-16.
  2. Torshin I.Yu., Gromova O.A. Displaziya soedinitel'noi tkani, kletochnaya biologiya i molekulyarnye mekhanizmy vozdeistviya magniya. Ros med zhurn 2008; 16; 4: 230-238.
  3. Arredondo F., Noble L.S. Endocrinology of recurrent pregnancy loss. Semin Reprod Med 2006; 24: 1: 33-39.
  4. Bernardini D., Nasulewic A., Mazur A., Maier J.A. Magnesium and microvascular endothelial cells: a role in inflammation and angiogenesis. Front Biosci 2005; 10: 1177-1182.
  5. Booth J.V., Phillips-Bute B., McCants C.B. et al. Low serum magnesium level predicts major adverse cardiac events after coronary artery bypass graft surgery. Am Heart J 2003; 145: 6: 1108-1113.
  6. Deruelle P., Coulon C. The use of low-molecular-weight heparins in pregnancy - how safe are they? Curr Opin Obstet Gynec 2007; 19: 6: 573-577.
  7. Empson M., Lassere M., Craig J.C., Scott J.R. Recurrent pregnancy loss with antiphospholipid antibody: a systematic review of therapeutic trials. Obstet Gynec 2002; 99: 1: 135-144.
  8. Erbel R., Di Mario C., Bartunek J. et al. Temporary scaffolding of coronary arteries with bioabsorbable magnesium stents: a prospective, non-randomised multicentre trial. Lancet 2007; 369: 9576: 1869-1875.
  9. Gatt A., Makris M. Hyperhomocysteinemia and venous thrombosis. Semin Hematol 2007; 44: 2: 70-76.
  10. Herbig K., Chiang E.P., Lee L.R. et al. Cytoplasmic serine hydroxymethyltransferase mediates competition between folate-dependent deoxyribonucleotide and S-adenosylmethionine biosyntheses. J Biol Chem 2002; 277: 41: 38 381-38 389.
  11. Irminger-Finger I., Jastrow N., Irion O. Preeclampsia: a danger growing in disguise. Int J Biochem Cell Biol 2008; 40: 10: 1979-1983.
  12. Krabbendam I., Franx A., Bots M.L. et al. Thrombophilias and recurrent pregnancy loss: a critical appraisal of the literature. Eur J Obstet Gynec Reprod Biol 2005; 118: 2: 143-153.
  13. Maier J.A., Bernardini D., Rayssiguier Y., Mazur A. High concentrations of magnesium modulate vascular endothelial cell behaviour in vitro. Biochim Biophys Acta 2004; 1689: 1: 6-12.
  14. Mazur A., Maier J.A., Rock E. et al. Magnesium and the inflammatory response: potential physiopathological implications. Arch Biochem Biophys 2007; 458: 1: 48-56.
  15. Mor G. Inflammation and pregnancy: the role of toll-like receptors in trophoblast-immune interaction. Ann N Y Acad Sci 2008; 1127: 121-128.
  16. Nasulewicz A., Zimowska W., Bayle D. et al. Changes in gene expression in the lungs of Mg-deficient mice are related to an inflammatory process. Magnes Res 2004; 17 : 4: 259-263.
  17. Romero R., Gotsch F., Pineles B., Kusanovic J.P. Inflammation in pregnancy: its roles in reproductive physiology, obstetrical complications, and fetal injury. Nutr Rev 2007; 65: 12: Pt 2: S194-S202.
  18. Rukshin V., Santos R., Gheorghiu M. et al. A prospective, nonrandomized, open-labeled pilot study investigating the use of magnesium in patients undergoing nonacute percutaneous coronary intervention with stent implantation. J Cardiovasc Pharmacol Ther 2003; 8: 3: 193-200.
  19. Ruttmann T.G., Montoya-Pelaez L.F., James M.F. The coagulation changes induced by rapid in vivo crystalloid infusion are attenuated when magnesium is kept at the upper limit of normal. Anesth Analg 2007; 104: 6: 1475-1480.
  20. Shechter M. The role of magnesium as antithrombotic therapy. Wien Med Wochenschr 2000; 150: 15-16: 343-347.
  21. Shechter M., Merz C.N., Rude R.K. et al. Low intracellular magnesium levels promote platelet-dependent thrombosis in patients with coronary artery disease. Am Heart J 2000; 140: 2: 212-218.
  22. Slottow T.L., Pakala R., Okabe T. et al. Optical coherence tomography and intravascular ultrasound imaging of bioabsorbable magnesium stent degradation in porcine coronary arteries. Cardiovasc Revasc Med 2008; 9: 4: 248-254.
  23. Song Y., Li T.Y., van Dam R.M. et al. Magnesium intake and plasma concentrations of markers of systemic inflammation and endothelial dysfunction in women. Am J Clin Nutr 2007; 85: 4: 1068-1074.
  24. Torshin I.Yu. Bioinformatics in the post-genomic era: physiology and medicine. Nova Biomedical Books: NY: USA 2007; 35-67.
  25. Wuillemin W.A., Solenthaler M. Hyperhomocysteinemia: a risk factor for arterial and venous thrombosis. Vasa 1999; 28: 3: 151-155.
  26. Yamada H., Kato E.H., Kobashi G. et al. Recurrent pregnancy loss: etiology of thrombophilia. Semin Thromb Hemost 2001; 27: 2: 121-129.
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.