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Grigoryan M.Zh.

Patrice Lumumba Peoples’ Friendship University of Russia (RUDN University), Moscow, Russia

Makeeva M.K.

Patrice Lumumba Peoples’ Friendship University of Russia (RUDN University), Moscow, Russia

Nalbandyan K.G.

Federal State Budgetary Institution of the Central State Medical Academy of the Central State Medical Academy of the Russian Federation, Moscow, Russia

Nakonechny D.A.

Department of Oral and maxillofacial surgery and Surgical dentistry, Federal State Budgetary Educational Institution of Higher Education, Smolensk, Russia

Andreasyan T.Sh.

“Corona” Dental Clinic, Tuapse, Russia

Fomin M.S.

Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia

Kirushin M.A.

Federal State Budgetary Institution of the Central State Medical Academy of the Central State Medical Academy of the Russian Federation, Moscow, Russia

Modern methods and concepts for the treatment of inflammatory diseases of the oral mucosa

Authors:

Grigoryan M.Zh., Makeeva M.K., Nalbandyan K.G., Nakonechny D.A., Andreasyan T.Sh., Fomin M.S., Kirushin M.A.

More about the authors

Journal: Russian Journal of Stomatology. 2026;19(1‑2): 174‑181

DOI: 10.17116/rosstomat202619012174

Read: 379 times

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Table of contents

MODERN METHODS AND CONCEPTS FOR THE TREATMENT OF INFLAMMATORY DISEASES OF THE ORAL MUCOSA
MODERN METHODS AND CONCEPTS FOR THE TREATMENT OF INFLAMMATORY DISEASES OF THE ORAL MUCOSA

To cite this article:

Grigoryan MZh, Makeeva MK, Nalbandyan KG, Nakonechny DA, Andreasyan TSh, Fomin MS, Kirushin MA. Modern methods and concepts for the treatment of inflammatory diseases of the oral mucosa. Russian Journal of Stomatology. 2026;19(1‑2):174‑181. (In Russ.)
https://doi.org/10.17116/rosstomat202619012174

Подписка 2026 Российская стоматология (Russian Journal of Stomatology)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Inflammatory diseases of the oral mucosa (IDOM) represent a common group of pathologies, often becoming chronic and significantly reducing patients’ quality of life. Traditional therapeutic approaches, including antiseptics, corticosteroids, and analgesics, are frequently insufficient, as they do not address the underlying causes of inflammation and fail to prevent relapses. This highlights the need for new, more effective, and pathogenetically justified treatment strategies for IDOM.

THE AIM

Of this study was to analyze modern therapeutic methods aimed at improving the clinical effectiveness of treating inflammatory diseases of the oral mucosa, with an assessment of their mechanisms of action. The main hypothesis was that low-level laser therapy (LLLT), probiotic therapy, and platelet-rich fibrin (PRF) could provide significant improvements in clinical outcomes and accelerate tissue healing.

MATERIALS AND METHODS

Included an analysis of scientific publications in international and domestic databases (PubMed, Scopus, eLibrary) from 2015 to 2025. Clinical studies, literature reviews, and meta-analyses assessing the effectiveness of LLLT, probiotics, and PRF were included. Publications were selected based on methodological rigor, scientific validity, and availability of quantitative treatment outcome data.

THE RESULTS

Demonstrated high clinical efficacy of the investigated methods. LLLT provides rapid pain relief and accelerates tissue repair by activating cellular metabolism and improving microcirculation. Probiotics help normalize oral microbiota and reduce the risk of candidal complications. PRF accelerates wound healing through localized release of growth factors and stimulation of regenerative processes.

THE STUDY CONCLUDES

That these methods are advisable for inclusion in individualized, comprehensive therapy for IDOM, while standardization of treatment protocols and investigation of combined therapeutic schemes remain relevant.

Keywords:

inflammatory diseases of the oral cavity
laser therapy
probiotics
PRF
comprehensive therapy

Authors:

Grigoryan M.Zh.

Patrice Lumumba Peoples’ Friendship University of Russia (RUDN University), Moscow, Russia

Makeeva M.K.

Patrice Lumumba Peoples’ Friendship University of Russia (RUDN University), Moscow, Russia

Nalbandyan K.G.

Federal State Budgetary Institution of the Central State Medical Academy of the Central State Medical Academy of the Russian Federation, Moscow, Russia

Nakonechny D.A.

Department of Oral and maxillofacial surgery and Surgical dentistry, Federal State Budgetary Educational Institution of Higher Education, Smolensk, Russia

Andreasyan T.Sh.

“Corona” Dental Clinic, Tuapse, Russia

Fomin M.S.

Sechenov First Moscow State Medical University, Ministry of Health of the Russian Federation (Sechenov University), Moscow, Russia

Kirushin M.A.

Federal State Budgetary Institution of the Central State Medical Academy of the Central State Medical Academy of the Russian Federation, Moscow, Russia

Received:

04.12.2025

Accepted:

17.02.2026

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References:

  1. Ślebioda Z, Dorocka-Bobkowska B. Low-level laser therapy in the treatment of recurrent aphthousstomatitis and oral lichen planus: a literature review // Postepy Dermatol Alergol. 2020. Vol. 37(4). P 475-481.  https://pubmed.ncbi.nlm.nih.gov/32994766/
  2. https://doi.org/10.18481/2077-7566-20-17-1-26-31 
  3. Spanemberg JC. Low-level Laser Therapy: A Review of Its Applications in the Management of Oral Mucosal Disorders // Altern Ther Health Med. 2016. Vol. 22(6). P 24-31.  https://pubmed.ncbi.nlm.nih.gov/27866178/
  4. Mundula T, Ricci F, Barbetta B. Candidiasis: A Systematic Review and Meta-Analysis // Nutrients. 2019. Vol. 11(10). P. 2449. https://pubmed.ncbi.nlm.nih.gov/31615039/
  5. https://doi.org/10.18481/2077-7566-20-16-2-5-10 
  6. Radithia D, Mahdani FY, Bakti RK. Effectiveness of low-level laser therapy in reducing pain score and healing time of recurrent aphthous stomatitis: a systematic review and meta-analysis // Syst Rev. 2024. Vol. 13. P. 192.  https://pubmed.ncbi.nlm.nih.gov/39039581/
  7. Al-Kheraif AA, Javed R, Al-Momani MM. Effectiveness of photodynamic therapy adjunct to oral debridement in improving clinical, microbiological, and pain in necrotizing ulcerative gingivitis // J Biophotonics. 2023. Vol. 16(10). https://pubmed.ncbi.nlm.nih.gov/37369626/
  8. Anschau F, Webster J, Capra MEZ. Efficacy of low-level laser for treatment of cancer oral mucositis: a systematic review and meta-analysis // Lasers Med Sci. 2019. Vol. 34(6). P 1053-1062. https://pubmed.ncbi.nlm.nih.gov/30729351/
  9. Samiraninezhad N, Rezazadeh H. Platelet-rich fibrin in the management of oral mucosal lesions: a scoping review // BMC Oral Health. 2024. Vol. 24(1). P. 1189. https://pubmed.ncbi.nlm.nih.gov/39369241/
  10. Gusman DJ, Matheus HR, Alves BE. Platelet-rich fibrin for wound healing of palatal donor sites of free gingival grafts: systematic review and meta-analysis // J Clin Exp Dent. 2021. Vol. 13(2). https://pubmed.ncbi.nlm.nih.gov/33575004/
  11. Yilmaz HG, Albaba MR, Caygur A. Treatment of recurrent aphthous stomatitis with Er,Cr:YSGG laser irradiation: a randomized controlled split mouth clinical study // Photochem Photobiol B 2017. Vol. 170. P. 1-5.  https://pubmed.ncbi.nlm.nih.gov/28359996/
  12. AlHerafi E, Hamadah O, Parker S. Photobiomodulation in recurrent aphthousstomatitis management using three different laser wavelengths: a randomized clinical trial // Lasers MedSci. 2024. Vol. 39(1). P. 285.  https://pubmed.ncbi.nlm.nih.gov/39557704/
  13. Jijin MJ, Rakaraddi M, Pai J. Low-level laser therapy versus 5% amlexanox: a comparison of treatment effects in a cohort of patients with minor aphthous ulcers // Oral Surg. 2016. Vol. 121(3). P. 269-273.  https://pubmed.ncbi.nlm.nih.gov/26868469/
  14. Huo X, Han N, Liu L. Effect of different treatments on recurrent aphthous stomatitis: laser versus medication // Lasers Med Sci. 2021; 36(5):1095-1100. https://pubmed.ncbi.nlm.nih.gov/33140267/
  15. https://doi.org/10.18481/2077-7566-2023-19-1-57-63 
  16. Ai R, Wei J, Ma D. A meta-analysis of randomized trials assessing the effects of probiotic preparations on oral candidiasis in the elderly // Arch Oral Biol. 2017. Vol. 83. P. 187-192.  https://pubmed.ncbi.nlm.nih.gov/28783552/
  17. Elsayes SA, El Attar MS, ElHadary A. Antimycoticprophylaxis with multispecies probiotics against oral candidiasis in new complete denture wearers: A randomized clinical trial // J Prosthet Dent. 2024. https://pubmed.ncbi.nlm.nih.gov/38906771/
  18. Hu L, Zhou M, Young A. In vivo effectiveness and safety of probiotics on prophylaxis and treatment of oral candidiasis: a systematic review and meta-analysis // BMC Oral Health. 2019. Vol. 19. P. 140.  https://pubmed.ncbi.nlm.nih.gov/31291932/
  19. Ishikawa KH, Mayer MP, Miyazima TY. A multispecies probiotic reduces oral Candida colonization in denture wearers // J Prosthodont. 2015. Vol. 24(3). P. 194-199.  https://pubmed.ncbi.nlm.nih.gov/25143068/
  20. Shu Z, Li P, Yu B. The effectiveness of probiotics in prevention and treatment of cancer therapy-induced oral mucositis: a systematic review and meta-analysis // Oral Oncol. 2020. Vol. 102.  https://pubmed.ncbi.nlm.nih.gov/31923856/
  21. Liu YC, Wu CR, Huang TW. Preventive effect of probiotics on oral mucositis induced by cancer treatment: a systematic review and meta-analysis // Int J Mol Sci. 2022. Vol. 23(21). P. 13268. https://www.researchgate.net/publication/365064424_Preventive_Effect_of_Probiotics_on_Oral_Mucositis_Induced_by_Cancer_Treatment_A_Systematic_Review_and_Meta-Analysis
  22. Minervini G, Franco R, Marrapodi MM. Probiotics in the treatment of radiotherapy-induced oral mucositis: systematic review with meta-analysis // Pharmaceuticals (Basel). 2023. Vol. 16(5). P. 654.  https://pubmed.ncbi.nlm.nih.gov/37242437/
  23. Mahajan M, Gupta MK, Bande C. Comparative evaluation of healing pattern after surgical excision of oral mucosal lesions by using platelet-rich fibrin (PRF) membrane and collagen membrane as grafting materials — a randomized clinical trial // J Oral Maxillofac Surg. 2018. Vol. 76(7). https://pubmed.ncbi.nlm.nih.gov/29601789/
  24. https://doi.org/10.18481/2077-7566-2025-21-1-31-36 
  25. Ustaoğlu G, Ercan E, Tunali M. The role of titanium-prepared platelet-rich fibrin in palatal mucosal wound healing and histoconduction // ActaOdontol Scand. 2016. Vol. 74(7). P. 558-564.  https://pubmed.ncbi.nlm.nih.gov/27538770/
  26. Lacy JA, Palaiologou AA. Donor site wound healing following free gingival graft surgery using platelet rich fibrin: a randomized controlled trial // J Periodontol. 2024. Vol. 95(7). P 632-639.  https://pubmed.ncbi.nlm.nih.gov/38884613/
  27. Song P, He D, Ren S. Platelet-rich fibrin in dentistry // J Appl Biomater Funct Mater. 2024. Vol. 22.  https://pubmed.ncbi.nlm.nih.gov/39588592/
  28. Gupta N, Bhargava A, Saigal S. Effectiveness of injectable platelet-rich fibrin in the treatment of oral lichen planus: a systematic review and meta-analysis // Cureus. 2024. Vol. 16(1). https://pmc.ncbi.nlm.nih.gov/articles/PMC10839423/
  29. Alshemmari KA, Alzafiri S, Alajmi M. Intra-lesional corticosteroids versus platelet-rich plasma versus platelet-rich fibrin for the treatment of oral lichen planus: a systematic review and network meta-analysis // Cureus. 2024. Vol. 16(9). https://pubmed.ncbi.nlm.nih.gov/39329035/
  30. Sousa F, Machado V, Botelho J. Effect of A-PRF application on palatal wound healing after free gingival graft harvesting: a prospective randomized study // Eur J Dent. 2020. Vol. 14(1). P. 63-69.  https://pubmed.ncbi.nlm.nih.gov/32168533/
  31. Graeme E. Photobiomodulation: a review of the molecular evidence for low level light therapy // J Plast. 2021. Vol. 74(5). P. 1050-1060. https://pubmed.ncbi.nlm.nih.gov/33436333/
  32. Shamloo S, Defensor E, Ciari P. The anti-inflammatory effects of photobiomodulation are mediated by cytokines: evidence from a mouse model of inflammation // Front Neurosci. 2023. Vol. 17.  https://pubmed.ncbi.nlm.nih.gov/37090796/
  33. Santonocito S, Polizzi A, Cavalcanti R. Impact of laser therapy on periodontal and peri-implant diseases // Photobiomodul Photomed Laser Surg. 2022. Vol. 40(7). P. 454-462.  https://pubmed.ncbi.nlm.nih.gov/35763842/
  34. Reyad AA, Mishriky R, Girgis E. Pharmacological and non-pharmacological management of burning mouth syndrome: a systematic review // Dent Med Probl. 2020. Vol. 57(3). P. 295-304.  https://pubmed.ncbi.nlm.nih.gov/33113291/
  35. Contaldo M, Di Stasio D, Romano A. Oral candidiasis and novel therapeutic strategies: antifungals, phytotherapy, probiotics, and photodynamic therapy // Curr Drug Deliv. 2023. Vol. 20(5). P. 441-456.  https://pubmed.ncbi.nlm.nih.gov/35440307/
  36. Archambault LS, Dongari-Bagtzoglou A. Probiotics for oral candidiasis: critical appraisal of the evidence and a path forward // Front Oral. Health. 2022. Vol. 3. P. 880746. https://pubmed.ncbi.nlm.nih.gov/35495563
  37. Hoseinpour Jajarm H, Asadi R, Bardideh E. The effects of photodynamic and low-level laser therapy for treatment of oral lichen planus — a systematic review and meta-analysis // Photodiagnosis PhotodynTher. 2018. Vol. 23. P. 254-260.  https://pubmed.ncbi.nlm.nih.gov/30006319/
  38. Özalp Ö, Sindel A, Altay MA. Comparative evaluation of the efficacy of ozone therapy and low-level laser therapy on oral mucosal wound healing in rat experimental model // J Stomatol Oral MaxillofacSurg. 2022. Vol. 123(6). https://pubmed.ncbi.nlm.nih.gov/35390514/
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