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Yusupov F.A.

Osh State University, Medical Faculty

Abdykadyrov M.Sh.

Osh State University, Medical Faculty

Gut ecosystem: a new insight on hyperuricemia mechanisms

Authors:

Yusupov F.A., Abdykadyrov M.Sh.

More about the authors

Journal: Russian Journal of Preventive Medicine. 2026;29(1): 123‑129

DOI: 10.17116/profmed202629011123

Read: 448 times

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Table of contents

GUT ECOSYSTEM: A NEW INSIGHT ON HYPERURICEMIA MECHANISMS
GUT ECOSYSTEM: A NEW INSIGHT ON HYPERURICEMIA MECHANISMS

To cite this article:

Yusupov FA, Abdykadyrov MSh. Gut ecosystem: a new insight on hyperuricemia mechanisms. Russian Journal of Preventive Medicine. 2026;29(1):123‑129. (In Russ.)
https://doi.org/10.17116/profmed202629011123

Подписка 2026 Профилактическая медицина (Russian Journal of Preventive Medicine)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Hyperuricemia is a metabolic disorder characterized by elevated level of uric acid (UA). Intestinal microbiota plays an important role in the regulation of UA content. About one third of UA is excreted through the intestine, where bacteria break down purines, reducing their production and increasing excretion. Dysbiosis can disrupt this process by increasing the intestinal wall permeability and promoting inflammation, which worsens the metabolism of purines.

OBJECTIVE

To study the impact of intestinal microbiota on uric acid exchange, identify key mechanisms of hyperuricemia and evaluate therapeutic approaches for its prevention and treatment through microbiota correction.

MATERIALS AND METHODS

A systematic search for publications (2020—2025) in scientific databases was carried out in order to analyze the mechanisms of hyperuricemia with emphasis on the role of intestinal microbiota. The following keywords were used: hyperuricemia, uric acid, intestinal microbiota, dysbiosis, purine exchange, intestinal excretion, interstitial permeability, inflammation, probiotics, prebiotics, fecal microbiota transplantation, diet, lifestyle.

RESULTS

The studies confirm the important role of intestinal microbiota in the regulation of UA level. About a third of UA is excreted through the intestine, where certain bacteria promote degradation of purines by reducing UA production, while others may increase it. Correction of microbiota by means of probiotics, prebiotics, herbal medicinal products and fecal microbiota transplantation is a promising therapeutic approach.

Keywords:

hyperuricemia
uric acid
intestinal microbiota
dysbiosis
gout
kidneys
probiotics
prebiotics
fecal transplantation

Authors:

Yusupov F.A.

Osh State University, Medical Faculty

Abdykadyrov M.Sh.

Osh State University, Medical Faculty

Received:

05.06.2025

Accepted:

07.10.2025

Close metadata

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