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Ignatova G.L.

Federal State Budgetary Educational Institution of Higher Education “South Ural State Medical University” of the Ministry of Health of the Russian Federation

Antonov V.N.

Federal State Budgetary Educational Institution of Higher Education “South Ural State Medical University” of the Ministry of Health of the Russian Federation

Rodionova O.V.

South Ural State Medical University

Belogorokhov V.S.

South Ural State Medical University

Coexistence of bronchial asthma and myasthenia gravis. (Clinical case)

Authors:

Ignatova G.L., Antonov V.N., Rodionova O.V., Belogorokhov V.S.

More about the authors

Journal: Journal of Respiratory Medicine. 2025;1(4): 53‑58

DOI: 10.17116/respmed2025104153

Read: 449 times

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Table of contents

COEXISTENCE OF BRONCHIAL ASTHMA AND MYASTHENIA GRAVIS. (CLINICAL CASE)
COEXISTENCE OF BRONCHIAL ASTHMA AND MYASTHENIA GRAVIS. (CLINICAL CASE)

To cite this article:

Ignatova GL, Antonov VN, Rodionova OV, Belogorokhov VS. Coexistence of bronchial asthma and myasthenia gravis. (Clinical case). Journal of Respiratory Medicine. 2025;1(4):53‑58. (In Russ.)
https://doi.org/10.17116/respmed2025104153

Подписка 2026 Респираторная медицина (Journal of Respiratory Medicine)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Bronchial asthma and myasthenia gravis are immune-mediated disorders with potential shared pathogenic mechanisms. The coexistence of these conditions creates significant challenges in clinical management. Furthermore, determining the etiology of respiratory symptoms requires a multidisciplinary approach involving pulmonologists and comprehensive pulmonary function testing. Critical diagnostic measures include spirometry with bronchodilator testing to confirm bronchial obstruction and its reversibility, along with assessment of respiratory muscle strength through maximal inspiratory and expiratory pressure (MIP/MEP) measurements to exclude a neuromuscular component of dyspnea. This article presents a clinical case of comorbid bronchial asthma and myasthenia gravis in a 73-year-old female patient.

Keywords:

bronchial asthma
myasthenia gravis
comorbidity
differential diagnosis
interdisciplinary approach

Authors:

Ignatova G.L.

Federal State Budgetary Educational Institution of Higher Education “South Ural State Medical University” of the Ministry of Health of the Russian Federation

Antonov V.N.

Federal State Budgetary Educational Institution of Higher Education “South Ural State Medical University” of the Ministry of Health of the Russian Federation

Rodionova O.V.

South Ural State Medical University

Belogorokhov V.S.

South Ural State Medical University

Received:

13.10.2025

Accepted:

13.11.2025

Close metadata

References:

  1. Gilhus NE. Myasthenia Gravis. N Engl J Med. 2016;375(26):2570-2581. https://doi.org/10.1056/NEJMra1602678
  2. Gilhus NE, Verschuuren JJ. Myasthenia gravis: subgroup classification and therapeutic strategies. Lancet Neurol. 2015;14(10):1023-1036. https://doi.org/10.1016/S1474-4422(15)00145-3
  3. Bubuioc AM, Kudebayeva A, Turuspekova S, Lisnic V, Leone MA. The epidemiology of myasthenia gravis. J Med Life. 2021;14(1):7-16.  https://doi.org/10.25122/jml-2020-0145
  4. Dresser L, Wlodarski R, Rezania K, Soliven B. Myasthenia Gravis: Epidemiology, Pathophysiology and Clinical Manifestations. J Clin Med. 2021;10(11):2235. https://doi.org/10.3390/jcm10112235
  5. Yingchoncharoen P, Charoenngam N, Ponvilawan B, Thongpiya J, Chaikijurajai T, Ungprasert P. The Association Between Asthma and Risk of Myasthenia Gravis: A Systematic Review and Meta-Analysis. Lung. 2021;199:273-280.  https://doi.org/10.1007/s00408-021-00452-8
  6. Murai H, Hara H, Hatae T, Kobayashi T, Watanabe T. Expression of CD23 in the germinal center of thymus from myasthenia gravis patients. J Neuroimmunol. 1997;76(1-2):61-9.  https://doi.org/10.1016/s0165-5728(97)00030-1
  7. Garifullin AI, Sultanova EI, Asfandiyarova IV, Khusainova AB, Gordeeva ME, Shakirova AR, Korneeva AA, Tukaev AF, Efremova DN, Sinitsina AS, Sobyanina EO, Usmanova AR, Ikhsanova EI. Myasthenia gravis: features of epidemiology, pathogenesis, treatment and relation to thymomas. Russian Neurological Journal. 2023;28(2):5-14. (In Russ.). https://doi.org/10.30629/2658-7947-2023-28-2-5-14
  8. Uzawa A, Kuwabara S, Suzuki S, Imai T, Murai H, Ozawa Y, Yasuda M, Nagane Y, Utsugisawa K. Roles of cytokines and T cells in the pathogenesis of myasthenia gravis. Clin Exp Immunol. 2021;203(3):366-374.  https://doi.org/10.1111/cei.13546
  9. Satkunam N, Siddiqi ZA, Vethanayagam D. Severe asthma associated with myasthenia gravis. Can Respir J. 2014;21(1):e1-3.  https://doi.org/10.1155/2014/979673
  10. Elsais A, Johansen B, Kerty E. Airway limitation and exercise intolerance in well-regulated myasthenia gravis patients. Acta Neurol Scand Suppl. 2010;190:12-17. 
  11. Meshram SB, Anand A, Orakkan RG. Cough-Variant Asthma in a Myasthenia Gravis Patient on Treatment With Steroids and Rituximab. Cureus. 2024;16(10):e71512. https://doi.org/10.7759/cureus.71512
  12. Echaniz-Laguna A, Pistea C, Philippi N, Enache I, Oswald-Mammosser M, De Sèze J, Charloux A. Asthma as a Cause of Persistent Dyspnea in Treated Myasthenia Gravis Patients. Eur Neurol. 2012;68:300-303.  https://doi.org/10.1159/000341834
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