The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Khalitova R.Sh.

Bashkir State Medical University

Yashchuk A.G.

Bashkir State Medical University

Nasyrova S.F.

Bashkir State Medical University

Tyurina A.A.

Bashkir State Medical University

The effect of intestinal and vaginal microflora on the risk of premature birth in pregnant women with a short cervix

Authors:

Khalitova R.Sh., Yashchuk A.G., Nasyrova S.F., Tyurina A.A.

More about the authors

Journal: Russian Bulletin of Obstetrician-Gynecologist. 2025;25(4): 66‑72

DOI: 10.17116/rosakush20252504166

Read: 1155 times

Contact the author
Table of contents

THE EFFECT OF INTESTINAL AND VAGINAL MICROFLORA ON THE RISK OF PREMATURE BIRTH IN PREGNANT WOMEN WITH A SHORT CERVIX
THE EFFECT OF INTESTINAL AND VAGINAL MICROFLORA ON THE RISK OF PREMATURE BIRTH IN PREGNANT WOMEN WITH A SHORT CERVIX

To cite this article:

Khalitova RSh, Yashchuk AG, Nasyrova SF, Tyurina AA. The effect of intestinal and vaginal microflora on the risk of premature birth in pregnant women with a short cervix. Russian Bulletin of Obstetrician-Gynecologist. 2025;25(4):66‑72. (In Russ.)
https://doi.org/10.17116/rosakush20252504166

Подписка 2026 Российский вестник акушера-гинеколога (Russian Bulletin of Obstetrician-Gynecologist)
МСФ на ЯМ
Использование инфографики авторами научных работ
Recommended articles:
Expe­rience in pregnancy and childbirth mana­gement in women with transplanted organs. Russian Bulletin of Obstetrician-Gynecologist. 2026;(2):20-28
Lactobacilli and bacterial vagi­nosis. Species typing and analysis of content levels in the microbiome. Mole­cular Gene­tics, Microbiology and Viro­logy. 2025;(2):43-50
Gut—brain: inte­ractions in health and pathology. Russian Journal of Preventive Medi­cine. 2025;(11):106-112
Gut ecosystem: a new insi­ght on hype­ruricemia mechanisms. Russian Journal of Preventive Medi­cine. 2026;(1):123-129
Sele­ctive neurodegeneration in patients with parkinson’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2026;(2):23-31
Rela­tionship between inte­stinal microbiota and psoriasis pathogenesis. Russian Journal of Clinical Dermatology and Vene­reology. 2026;(1):15-22
Abstract:

OBJECTIVE

To study the effect of the microbiota of the vagina and intestines on the risk of premature birth in pregnant women with a short cervix.

MATERIALS AND METHODS

130 patients with a cervical length of 2.5 cm or less were examined during pregnancy and after childbirth, among whom two groups were formed: 1st (main) — 68 patients who gave birth prematurely and the 2nd (control) — 62 patients who gave term birth. The assessment of the vaginal microflora was carried out by polymerase chain reaction in real time. The parameters of the colon microflora were studied using culture and mass spectrometric methods.

RESULTS

Patients in group 1 were more likely to have a decrease in the total number of Lactobacilli in the vaginal contents (χ2=10.94; p=0.0005; OR=3.93; 95% CI — (1.8—8.7)), statistically significant differences were found between the studied groups in the frequency of detection of Gardnerella vag. (χ2=16.8; p=0.00002; OR=6.6 DI (2.6—16.5), and Atopobium vag. (χ2=8.5; p=0.001; OR=3.92 CI (1.6—9.5)). In the study of intestinal microflora, conditionally pathogenic microorganisms of facultative anaerobic origin S. aureus were statistically significantly more common in patients of the 1st group. (p=0.04) and Cl. pneumoniae (p=0.02), with a higher number of colony -forming units. At the same time, there was a decrease in lactobacilli (p=0.009) and obligate anaerobic bacteria of the Bacteroidaceae family (p=0.044). Based on the results of the study of the microbiocenosis of the vagina and intestines, a prognostic model for assessing the risk of premature birth in women with a short cervix was developed, which had a very good diagnostic value and statistical significance (AUC=0.834; p<0.0001).

CONCLUSION

The determination of the microbial composition of the vagina and intestines will significantly improve the prognosis of premature birth in pregnant women with a short cervix.

Keywords:

vaginal microbiocenosis
intestinal microbiota
premature birth
pregnant women with a short cervix
prognosis of premature birth

Authors:

Khalitova R.Sh.

Bashkir State Medical University

Yashchuk A.G.

Bashkir State Medical University

Nasyrova S.F.

Bashkir State Medical University

Tyurina A.A.

Bashkir State Medical University

Received:

10.03.2025

Accepted:

01.04.2025

Close metadata

References:

  1. Gorina KA, Khodzhaeva ZS, Belousov DM, Baranov II, Gokhberg YaA, Pashchenko AA. Premature birth: past limitations and new opportunities. Akusherstvo i ginekologiya. 2020;1:12-19. (In Russ.). https://doi.org/10.18565/aig.2020.1.12-119
  2. Belousova VS, Strizhakov AN, Svitich OA, Timokhina EV, Kukina PI, Bogomazova IM, Pitskhelauri EG. Premature birth: causes, pathogenesis, tactics. Akusherstvo i ginekologiya. 2020;2:82-87. (In Russ.). https://doi.org/10.18565/aig.2020.2.82-87
  3. Dolgushina VF, Kurnosenko IV, Alikhanova ES, Semenov YuA. Cervical and Vaginal Infections in Insuficiencia Istmicocervical. Doctor.Ru. 2021;20:1:61-67. (In Russ.).
  4. Dolgushina VF, Astashkina MV, Semenov YuA, Kurnosenko IV. Cervicovaginal infections in women with spontaneous early preterm labor. Vestnik SurGU. Meditsina. 2020;2:44:41-45. (In Russ). https://doi.org/10.34822/2304-9448-2020-2-41-45
  5. Nuriel-Ohayon M, Neuman H, Koren O. Microbial changes during pregnancy, birth, and infancy. Front Microbiol. 2016;7:JUL.  https://doi.org/10.3389/FMICB.2016.01031
  6. Nikolaeva AV, Kozlova AA, Baranov II, Priputnevich TV. Modern concepts of the relationship between intestinal and vaginal microbiota. Akusherstvo i ginekologiya. 2021;9:5-11. (In Russ). https://doi.org/10.18565/aig.2021.9.5-11
  7. Mendes-Soares H, Suzuki H, Hickey RJ, Forneya LJ. Comparative functional genomics of Lactobacillus spp. reveals possible mechanisms for specialization of vaginal lactobacilli to their environment. J Bacteriol. 2014;196:7:1458-1470. https://doi.org/10.1128/JB.01439-13
  8. Nelson TM, Borgogna JLC, Brotman RM, Ravel J, Walk ST, Yeoman CJ. Vaginal biogenic amines: biomarkers of bacterial vaginosis or precursors to vaginal dysbiosis? Front Physiol. 2015;6:SEP.  https://doi.org/10.3389/FPHYS.2015.00253
  9. Onderdonk AB, Delaney ML, Fichorova RN. The Human microbiome during bacterial vaginosis. Clin Microbiol Rev. 2016;29:2:223-238.  https://doi.org/10.1128/CMR.00075-15
  10. Gorina KA, Khodzhaeva ZS, Murav’eva VV, Muminova KT, Donnikov AE, Priputnevich TV. The role of maternal intestinal microbiota in spontaneous preterm birth. Akushersvo i ginekologiya. 2020;8:64-71. (In Russ). https://doi.org/10.18565/aig.2020.8.64-71
  11. Schuster HJ, Breedveld AC, Matamoros SPF. The interrelation between microbial immunoglobulin coating, vaginal microbiota, ethnicity, and preterm birth. Microbiome. 2024;12:1:1-10.  https://doi.org/10.1186/S40168-024-01787-Z
  12. Lu X, Shi Z, Jiang L, Zhang S. Maternal gut microbiota in the health of mothers and offspring: from the perspective of immunology. Front Immunol. 2024;15:1362784. https://doi.org/10.3389/FIMMU.2024.1362784
  13. Holm JB, France MT, Gajer P. Integrating compositional and functional content to describe vaginal microbiomes in health and disease. Microbiome. 2023;11:1:1-20.  https://doi.org/10.1186/S40168-023-01692-X
  14. Koren O, Konnikova L, Brodin P, Mysorekar IU, Collado MC. The maternal gut microbiome in pregnancy: implications for the developing immune system. Nat Rev Gastroenterol Hepatol 2023;21:1:35-45.  https://doi.org/10.1038/s41575-023-00864-2
  15. Huang C, Gin C, Fettweis J, Foxman B, Gelaye B, MacIntyre DA, Subramaniam A, Fraser W, Tabatabaei N, Callahan B. Meta-analysis reveals the vaginal microbiome is a better predictor of earlier than later preterm birth. BMC Biol. 2023;21:1:1-16.  https://doi.org/10.1186/S12915-023-01702-2
  16. Li H, Han M, Xu J, Li N, Cui H. The vaginal microbial signatures of preterm birth woman. BMC Pregnancy Childbirth. 2024;24:1:1-12.  https://doi.org/10.1186/S12884-024-06573-1
  17. Wu R, Luan J, Hu J, Li Z. Effect of probiotics on pregnancy outcomes in gestational diabetes: systematic review and meta-analysis. Arch Gynecol Obstet. 2024;1—13.  https://doi.org/10.1007/S00404-023-07346-5
  18. Semenov YuA, Dolgushina VF, Moskvicheva MG, Chulkov VS Optimization of management of pregnant women at high risk of miscarriage and premature birth. Russian Bulletin of Obstetrician-Gynecologist. 2020;20:1:54-60. (In Russ.). https://doi.org/10.17116/rosakush20202001154
  19. Dalnikovskaya LA, Novikova SV, Budykina TS, Biryukova NV, Klimova IV, Isubova IR. The value of the biochemical markers’ study for the diagnosis and prognosis of premature birth in women with a shortened cervix. Russian Bulletin of Obstetrician-Gynecologist. 2021;21:4:14-19. (In Russ.). https://doi.org/10.17116/rosakush20212104114
  20. Smirnova AV, Borzova NYu, Malyshkina AI, Talanova IE. Prospects for predicting preterm labor. Russian Bulletin of Obstetrician-Gynecologist. 2023;23:6-2:127—134. (In Russ.). https://doi.org/10.17116/rosakush202323062127
  21. Sergeeva AV, Katkova NYu, Bodrikova OI, Kovalishena O.V., Bezrukova IM, Pokusaeva KB. Clinical and microbiological characteristics of the state of vaginal biocenosis among patients with preterm labor. Epidemiologiya i vaktsinoprofilaktira. 2020;19:1:51-57. (In Russ.). https://doi.org/10.31631/2073-3046-2020-19-1-51-57
  22. Parnell LA, Briggs CM, Mysorekar IU. Maternal microbiomes in preterm birth: Recent progress and analytical pipelines. Semin Perinatol. 2017;41:7:392-400.  https://doi.org/10.1053/j.semperi.2017.07.010
  23. Dahl C, Stanislawski M, Iszatt N, Mandal S, Lozupone C, Clemente JC, Knight R, Stigum H, Eggesbø M. Gut microbiome of mothers delivering prematurely shows reduced diversity and lower relative abundance of Bifidobacterium and Streptococcus. PLoS One. 2017;12:10:e0184336. https://doi.org/10.1371/journal.pone.0184336
  24. Shiozaki A, Yoneda S, Yoneda N, Yonezawa R, Matsubayashi T, Seo G, Saito S. Intestinal microbiota is different in women with preterm birth:results from terminal restriction fragment length polymorphism analysis. PloSone. 2014;9:11:e111 374.  https://doi.org/10.1371/journal.pone.0111374
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.