Subclinical sclerosis is detected in about 50% of adult people (30 to 70% depending on localization). Subclinical sclerosis frequency is the same in people with low cardiovascular risk, thus limiting the feasibility of integral prognostic scales. The subclinical sclerosis comorbidity with other somatic diseases plays an important prognostic role in the development of complications and can serve as an additional indicator for an extended examination. The somatic diseases that often accompany subclinical atherosclerosis include metabolic syndrome, progestogen-induced diabetes mellitus, fatty liver disease, psoriasis, antiphospholipid syndrome, arthritis, and systemic lupus erythematosus. The diseases associated with metabolic disorders, including those of a transient nature, systemic inflammatory disease of connective tissue and skin, are closely related to subclinical atherosclerosis. These peculiarities shall be considered when developing complex measures to prevent complications of comorbid conditions.