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Tret’yakov A.Yu.

Federal State Autonomous Educational Institution of Higher Education «Belgorod National Research University»

Zhabskaya A.V.

Belgorod National Research University;
Belgorod City Hospital No. 2

Radenska-Lopovok S.G.

Sechenov First Moscow State Medical University (Sechenov University)

Ermilov O.V.

Federal State Autonomous Educational Institution of Higher Education «Belgorod National Research University»;
Belgorod Region Clinical Hospital of Saint Ioasaf

Alferov P.K.

Belgorod National Research University;
St. Joasaph Belgorod Regional Clinical Hospital

Tretyakov M.A.

Belgorod National Research University

Polushina E.P.

Kursk State Medical University (KSMU)

Dynamics of interleukin 6 and its soluble receptor levels during 30-day rehabilitation after pneumonia according to the aerobic training program

Authors:

Tret’yakov A.Yu., Zhabskaya A.V., Radenska-Lopovok S.G., Ermilov O.V., Alferov P.K., Tretyakov M.A., Polushina E.P.

More about the authors

Journal: Russian Journal of Preventive Medicine. 2025;28(12): 130‑134

DOI: 10.17116/profmed202528121130

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Table of contents

DYNAMICS OF INTERLEUKIN 6 AND ITS SOLUBLE RECEPTOR LEVELS DURING 30-DAY REHABILITATION AFTER PNEUMONIA ACCORDING TO THE AEROBIC TRAINING PROGRAM
DYNAMICS OF INTERLEUKIN 6 AND ITS SOLUBLE RECEPTOR LEVELS DURING 30-DAY REHABILITATION AFTER PNEUMONIA ACCORDING TO THE AEROBIC TRAINING PROGRAM

To cite this article:

Tret’yakov AYu, Zhabskaya AV, Radenska-Lopovok SG, Ermilov OV, Alferov PK, Tretyakov MA, Polushina EP. Dynamics of interleukin 6 and its soluble receptor levels during 30-day rehabilitation after pneumonia according to the aerobic training program. Russian Journal of Preventive Medicine. 2025;28(12):130‑134. (In Russ.)
https://doi.org/10.17116/profmed202528121130

Подписка 2026 Профилактическая медицина (Russian Journal of Preventive Medicine)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To perform an analysis of the level of interleukin-6 (IL-6) and its soluble receptor (sIL-6R) when using aerobic physical exertion as a rehabilitation regimen after pneumonia.

MATERIALS AND METHODS

The study included 62 patients: after COVID-19-associated pneumonia (SARS-CoV-2 «Omicron» variant (C-AP), n=40) and bacterial community-acquired pneumonia (BCAP, n=22) at the stage of a 30-day recovery under an aerobic physical exertion (APE) program (n=28) or traditional regimen (control, n=34 at the initial stage and n=28 at the end of follow-up). Dynamics of the content of interleukin-6 (IL-6), its soluble receptor (sIL-6R) and pulmonary function parameters were evaluated.

RESULTS

APE aimed at rehabilitation is characterized by a lower final blood concentration of sIL-6R in patients with history of BCAP (p=0.0002, effect size (ES)=2.78) and C-AP (p=0.005, ES=1.1), loss of correlation with C-reactive protein level, increase in vital capacity (in men p=0.002; in women p=0.01), forced vital capacity (in men p=0.005; in women p=0.011) and forced expiratory volume in 1 second (in men p=0.009; in women p=0.009) compared to the control.

CONCLUSION

Aerobic exercise is a more effective rehabilitation regimen and associated with a lower total sIL-6R value in the blood after pneumonia.

Keywords:

aerobic physical exertion
pneumonia
interleukin-6
soluble interleukin-6 receptor

Authors:

Tret’yakov A.Yu.

Federal State Autonomous Educational Institution of Higher Education «Belgorod National Research University»

Zhabskaya A.V.

Belgorod National Research University;
Belgorod City Hospital No. 2

Radenska-Lopovok S.G.

Sechenov First Moscow State Medical University (Sechenov University)

Ermilov O.V.

Federal State Autonomous Educational Institution of Higher Education «Belgorod National Research University»;
Belgorod Region Clinical Hospital of Saint Ioasaf

Alferov P.K.

Belgorod National Research University;
St. Joasaph Belgorod Regional Clinical Hospital

Tretyakov M.A.

Belgorod National Research University

Polushina E.P.

Kursk State Medical University (KSMU)

Received:

05.08.2025

Accepted:

24.11.2025

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