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Veremeev A.V.

National Medical Research Center for Therapy and Preventive Medicine

Kiprina E.S.

National Medical Research Center for Therapy and Preventive Medicine

Berns S.A.

National Medical Research Center for Therapy and Preventive Medicine

Melkumyan A.R.

Ryzhikh National Medical Research Center of Coloproctology

Gilmutdinova I.R.

National Medical Research Center for Therapy and Preventive Medicine

Zhdanova O.V.

National Medical Research Center for Therapy and Preventive Medicine

Drapkina O.M.

National Medical Research Center for Therapy and Preventive Medicine;
A.I. Yevdokimov Moscow State University of Medicine and Dentistry

Gut—brain: interactions in health and pathology

Authors:

Veremeev A.V., Kiprina E.S., Berns S.A., Melkumyan A.R., Gilmutdinova I.R., Zhdanova O.V., Drapkina O.M.

More about the authors

Journal: Russian Journal of Preventive Medicine. 2025;28(11): 106‑112

DOI: 10.17116/profmed202528111106

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Table of contents

GUT—BRAIN: INTERACTIONS IN HEALTH AND PATHOLOGY
GUT—BRAIN: INTERACTIONS IN HEALTH AND PATHOLOGY

To cite this article:

Veremeev AV, Kiprina ES, Berns SA, Melkumyan AR, Gilmutdinova IR, Zhdanova OV, Drapkina OM. Gut—brain: interactions in health and pathology. Russian Journal of Preventive Medicine. 2025;28(11):106‑112. (In Russ.)
https://doi.org/10.17116/profmed202528111106

Подписка 2026 Профилактическая медицина (Russian Journal of Preventive Medicine)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Gut-brain axis conception is an important achievement in understanding relationship between the gastrointestinal and central nervous systems functioning.

OBJECTIVE

To study the nature of relationship between the gut and the brain.

MATERIALS AND METHODS

An analysis of domestic and foreign reviews, original articles, monographs, clinical and laboratory studies descriptions published over the past 5 years and presented in PubMed, eLibrary and RSCI databases was carried out. The following keywords were used: «gut-brain» axis», «gut microbiota», «inflammation», «neuromodulation», «gastrointestinal tract». The number of sources equal 57 has been analyzed.

RESULTS

An analysis of neuroanatomical pathways, hormonal signals and the role of gut microbiota in the modulating brain functions is presented. The pathology resulting from disruption of relationships between the gut and the brain is considered. Current and future therapeutic strategies are being discussed.

CONCLUSION

Studying the «gut-brain» axis has the potential to change approach to diagnosis, treatment and prevention of both gastrointestinal tract pathology and neurodegenerative diseases.

Keywords:

«gut-brain» axis
gut microbiota
inflammation
neuromodulation
gastrointestinal tract

Authors:

Veremeev A.V.

National Medical Research Center for Therapy and Preventive Medicine

Kiprina E.S.

National Medical Research Center for Therapy and Preventive Medicine

Berns S.A.

National Medical Research Center for Therapy and Preventive Medicine

Melkumyan A.R.

Ryzhikh National Medical Research Center of Coloproctology

Gilmutdinova I.R.

National Medical Research Center for Therapy and Preventive Medicine

Zhdanova O.V.

National Medical Research Center for Therapy and Preventive Medicine

Drapkina O.M.

National Medical Research Center for Therapy and Preventive Medicine;
A.I. Yevdokimov Moscow State University of Medicine and Dentistry

Received:

04.08.2025

Accepted:

02.09.2025

Close metadata

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