The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-0604
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2025
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Katser A.B.

Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University;
Krasnoyarsk Regional Clinical Hospital

Demko I.V.

Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University;
Krasnoyarsk Regional Clinical Hospital

Sobko E.A.

Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University;
Krasnoyarsk Regional Clinical Hospital

Grishkov A.V.

Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University

Esophageal pathology and bronchial asthma: pathogenetic interactions and possibilities for therapy optimization

Authors:

Katser A.B., Demko I.V., Sobko E.A., Grishkov A.V.

More about the authors

Journal: Russian Journal of Preventive Medicine. 2024;27(11): 129‑134

DOI: 10.17116/profmed202427111129

Read: 994 times

Buy for 300₽
Contact the author
Table of contents

ESOPHAGEAL PATHOLOGY AND BRONCHIAL ASTHMA: PATHOGENETIC INTERACTIONS AND POSSIBILITIES FOR THERAPY OPTIMIZATION
ESOPHAGEAL PATHOLOGY AND BRONCHIAL ASTHMA: PATHOGENETIC INTERACTIONS AND POSSIBILITIES FOR THERAPY OPTIMIZATION

To cite this article:

Katser AB, Demko IV, Sobko EA, Grishkov AV. Esophageal pathology and bronchial asthma: pathogenetic interactions and possibilities for therapy optimization. Russian Journal of Preventive Medicine. 2024;27(11):129‑134. (In Russ.)
https://doi.org/10.17116/profmed202427111129

 
Подписка 2026 Профилактическая медицина (Russian Journal of Preventive Medicine)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
Recommended articles:
Chro­nic inflammation in case of obesity-associated diseases. Russian Journal of Preventive Medi­cine. 2025;(1):115-121
Neutrophil elastase as a promising biomarker of low-grade inflammation in chro­nic non-communicable diseases. Russian Journal of Preventive Medi­cine. 2025;(4):142-148
Immu­notherapy in the treatment of chro­nic poly­pous rhinosinusitis with como­rbid bronchial asthma. Russian Bulletin of Otorhinolaryngology. 2025;(1):29-34
Acce­ssibility of health and preventive care for patients with bronchial asthma. Journal of Respiratory Medi­cine. 2025;(1):15-22
Effi­cacy of dupi­lumab application in bullous pemphigoid proceeding in presence of bronchial asthma. Russian Journal of Clinical Dermatology and Vene­reology. 2025;(2):204-209
High-accuracy eosi­nophil dete­ction in eosi­nophilic esophagitis histological images using machine learning model YOLO11. Russian Journal of Evidence-Based Gastroenterology. 2025;(2):19-29
Diseases of the upper gastrointestinal tract in pregnancy: what should the gastroenterologist consider?. Russian Journal of Evidence-Based Gastroenterology. 2025;(2):30-42
Mono­clonal anti­bodies in the treatment of recu­rrent poly­posis rhinosinusitis. Lite­rature review. Russian Bulletin of Otorhinolaryngology. 2025;(4):96-104
Mechanisms of addi­tivity of physiotherapeutic factors in complex therapy of poly­pous rhinosinusitis complicated by como­rbidities. Rege­nerative Biotechnologies, Preventive, Digi­tal and Predictive Medi­cine. 2025;(3):5-11
Abstract:

The review analyzes pathogenetic interactions between esophageal diseases and bronchial asthma (BA). BA often co-exists with gastroesophageal reflux disease (GERD), and the presence of GERD as a co-morbidity in BA patients prevents achieving control over the disease. BA co-morbidity with eosinophilic esophagitis is of special interest due to the commonality of pathophysiological reactions underlying T2 inflammation. The local immune regulation system disorder could be a link that unifies inflammation in the mucous membrane of the gastrointestinal or respiratory tract. The physician’s alertness in identifying and correcting concomitant pathology can definitely improve the main disease course.

Keywords:

bronchial asthma
gastroesophageal reflux disease
mucosal immunity
T2 inflammation
eosinophilic esophagitis

Authors:

Katser A.B.

Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University;
Krasnoyarsk Regional Clinical Hospital

Demko I.V.

Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University;
Krasnoyarsk Regional Clinical Hospital

Sobko E.A.

Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University;
Krasnoyarsk Regional Clinical Hospital

Grishkov A.V.

Prof. V.F. Voino-Yasenetsky Krasnoyarsk State Medical University

Received:

13.03.2024

Accepted:

14.07.2024

Close metadata

References:

  1. GINA 2023. Global Strategy for Asthma Management and Prevention. Global Initiative for Asthma (GINA). Accessed July 28, 2024. www.ginasthma.org
  2. Hekking PW, Amelink M, Wener RR, et al. Comorbidities in Difficult-to-Control Asthma. The Journal of Allergy and Clinical Immunology. In Practice. 2017;19:30473-30477. https://doi.org/10.1016/j.jaip.2017.06.008
  3. Cosío BG, Shafiek H, Mosteiro M, et al. Redefining the Role of Bronchoscopy in the Workup of Severe Uncontrolled Asthma in the Era of Biologics: A Prospective Study. Chest. 2023;164(4):837-845.  https://doi.org/10.1016/j.chest.2023.03.012
  4. Anaev EKh, Bobkov EV. Gastroesophageal Reflux Disease in patients with asthma. Prakticheskaja pul’monologija. 2020;2:22-32. (In Russ.).
  5. Anaev EKh, Bobkov EV. Gastroesophageal Reflux Disease in patients with Chronic Obstructive Lung Disease. Prakticheskaja pul’monologija. 2020;3:32-39. (In Russ.).
  6. Broers C, Tack J, Pauwels A. Review article: gastro-oesophageal reflux disease in asthma and chronic obstructive pulmonary disease. Alimentary Pharmacology and Therapeutics. 2018;47(2):176-191.  https://doi.org/10.1111/apt.14416
  7. Cheng X, Shi J, Zhang D, et al. Assessing the genetic relationship between gastroesophageal reflux disease and chronic respiratory diseases: a mendelian randomization study. BMC pulmonary medicine. 2023;23(1):243.  https://doi.org/10.1186/s12890-023-02502-8
  8. Capucilli P, Hill DA. Allergic Comorbidity in Eosinophilic Esophagitis: Mechanistic Relevance and Clinical Implications. Clinical Reviews in Allergy and Immunology. 2019;57(1):111-127.  https://doi.org/10.1007/s12016-019-08733-0
  9. Durrani SR, Mukkada VA, Guilbert TW. Eosinophilic Esophagitis: an Important Comorbid Condition of Asthma? Clinical Reviews in Allergy and Immunology. 2018;55(1):56-64.  https://doi.org/10.1007/s12016-018-8670-7
  10. Mishra A, Hogan SP, Brandt EB, Rothenberg ME. An etiological role for aeroallergens and eosinophils in experimental esophagitis. The Journal of Clinical Investigation. 2001;107(1):83-90.  https://doi.org/10.1172/JCI10224
  11. Hill DA, Grundmeier RW, Ramos M, Spergel JM. Eosinophilic Esophagitis Is a Late Manifestation of the Allergic March. The Journal of Allergy and Clinical Immunology. In Practice. 2018;6(5):1528-1533. https://doi.org/10.1016/j.jaip.2018.05.010
  12. Fedorova SO, Kozlova NM. Gastroesophageal reflux disease associated with diseases of the respiratory tract. Acta Biomedica Scientifica. 2018;3(3): 103-107. (In Russ.). https://doi.org/10.29413/ABS.2018-3.3.16
  13. Larina VN, Bondarenkova AA, Lunev VI, et al. Extra-esophageal symptoms of gastroesophageal reflux disease as manifestations of polymorbidity. Jeksperimental’naja i klinicheskaja gastrojenterologija. 2019;166(6):4-8. (In Russ.).
  14. Solidoro P, Patrucco F, Fagoonee S, Pellicano R. Asthma and gastroesophageal reflux disease: a multidisciplinary point of view. Minerva Medica. 2017;108(4):350-356.  https://doi.org/10.23736/S0026-4806.17.05181-3
  15. Abrosimov VN, Ponomareva IB, Nizov AA, Solodun MV. On respiratory manifestations of gastroesophageal reflux disease. Terapevticheskii arkhiv. 2018;90(8):131-136. (In Russ.). https://doi.org/10.26442/terarkh2018908131-136
  16. Houghton LA, Lee AS, Badri H, DeVault KR, Smith JA. Respiratory disease and the oesophagus: reflux, reflexes and microaspiration. Nature Reviews. Gastroenterology and Hepatology. 2016;13(8):445-460.  https://doi.org/10.1038/nrgastro.2016.91
  17. Ito K, Kanemitsu Y, Kamiya T, Fukumitsu K, et al. Functional gastrointestinal disorders are associated with capsaicin cough sensitivity in severe asthma. Allergology International. 2023;72(2):271-278.  https://doi.org/10.1016/j.alit.2022.08.009
  18. Kurokawa R, Kanemitsu Y, Fukumitsu K, et al. Reflux-related symptoms reflect poor asthma control and the presence of airway neuronal dysfunction. Allergology International. 2022;71(3):318-324.  https://doi.org/10.1016/j.alit.2021.12.003
  19. Kang HR, Lee YJ, Lee HY, et al. The Impact of Erosive Reflux Esophagitis on the Decline of Lung Function in the General Population. Journal of Korean Medical Science. 2021;36(5):e29.  https://doi.org/10.3346/jkms.2021.36.e29
  20. Althoff MD, Ghincea A, Wood LG, et al. Asthma and Three Colinear Comorbidities: Obesity, OSA, and GERD. The Journal of Allergy and Clinical Immunology. In Practice. 2021;9(11):3877-3884. https://doi.org/10.1016/j.jaip.2021.09.003
  21. Rogers L. Role of Sleep Apnea and Gastroesophageal Reflux in Severe Asthma. Immunology and Allergy Clinics of North America. 2016;36(3):461-471.  https://doi.org/10.1016/j.iac.2016.03.008
  22. Sericova SN, Korochanskaya N.V. Difficulties in the differential diagnosis of eosinophilic esophagitis and gastroesophageal reflux disease. Jeksperimental’naja i klinicheskaja gastrojenterologija. 2017;148(12):56-59. (In Russ.).
  23. Hait EJ, McDonald DR. Impact of Gastroesophageal Reflux Disease on Mucosal Immunity and Atopic Disorders. Clinical Reviews in Allergy and Immunology. 2019;57(2):213-225.  https://doi.org/10.1007/s12016-018-8701-4
  24. Fiocca R, Mastracci L, Engström C, et al. LOTUS trial collaborators. Long-term outcome of microscopic esophagitis in chronic GERD patients treated with esomeprazole or laparoscopic antireflux surgery in the LOTUS trial. The American Journal of Gastroenterology. 2010;105(5):1015-1023. https://doi.org/10.1038/ajg.2009.631
  25. Yoshida N, Katada K, Handa O, et al. Interleukin-8 production via protease-activated receptor 2 in human esophageal epithelial cells. International Journal of Molecular Medicine. 2007;19(2):335-340.  https://doi.org/10.3892/ijmm.19.2.335
  26. Jiao D, Ishimura N, Maruyama R, et al. Similarities and differences among eosinophilic esophagitis, proton-pump inhibitor-responsive esophageal eosinophilia, and reflux esophagitis: comparisons of clinical, endoscopic, and histopathological findings in Japanese patients. Journal of Gastroenterology. 2017;52(2):203-210.  https://doi.org/10.1007/s00535-016-1213-1
  27. Gratacós Gómez AR, Gómez Torrijos E. Eosinophilic Esophagitis due to Aeroallergens: A Systematic Review and Update. Journal of Investigational Allergology and Clinical Immunology. 2022;32(6):438-450.  https://doi.org/10.18176/jiaci.0853
  28. Arias Á, Lucendo AJ. Epidemiology and risk factors for eosinophilic esophagitis: lessons for clinicians. Expert Review of Gastroenterology and Hepatology. 2020;14(11):1069-1082. https://doi.org/10.1080/17474124.2020.1806054
  29. Aceves SS. Local Antigen Deposition in Eosinophilic Esophagitis:Implications for Immune Activation. Gastroenterology. 2019;157(1):17-20.  https://doi.org/10.1053/j.gastro.2019.05.044
  30. Golovanova VE, Mikhaleva, LM, Barkhina, TG, et al. Morphofunctional characteristics of the esophageal mucosa in bronchial asthma of varying severity. Rossijskij mediko-biologicheskij vestnik imeni akademika I.P. Pavlova. 2012;2:25-32. (In Russ.).
  31. Redd WD, Ocampo AA, Xue Z, et al. Eosinophilic esophagitis patients with multiple atopic conditions: Clinical characteristics and treatment response to topical steroids. Annals of Allergy, Asthma and Immunology. 2023;131(1): 109-115.e2.  https://doi.org/10.1016/j.anai.2023.04.026
  32. Valitova ER, Embutnieks YuV, Berezina OI, et al. Eosinophilic Esophagitis. Jeksperimental’naja i klinicheskaja gastrojenterologija. 2018;(10):115-119. (In Russ.).
  33. Khokhar D, Marella S, Idelman G, et al. Eosinophilic esophagitis: Immune mechanisms and therapeutic targets. Clinical and Experimental Allergy. 2022;52(10):1142-1156. https://doi.org/10.1111/cea.14196
  34. Bagnasco D, Savarino EV, Yacoub MR, et al. Personalized and Precision Medicine in Asthma and Eosinophilic Esophagitis: The Role of T2 Target Therapy. Pharmaceutics. 2023;15(9):2359. https://doi.org/10.3390/pharmaceutics15092359
  35. Ghebre YT, Raghu G. Idiopathic Pulmonary Fibrosis: Novel Concepts of Proton Pump Inhibitors as Antifibrotic Drugs. American Journal of Respiratory and Critical Care Medicine. 2016;193(12):1345-1352. https://doi.org/10.1164/rccm.201512-2316PP
  36. McDonnell MJ, Hunt EB, Ward C, et al. Current therapies for gastro-oesophageal reflux in the setting of chronic lung disease: state of the art review. ERJ Open Research. 2020;6(4):00190-2019. https://doi.org/10.1183/23120541.00190-2019
  37. Zheng Z, Luo Y, Li J, et al. Randomised trials of proton pump inhibitors for gastro-oesophageal reflux disease in patients with asthma: an updated systematic review and meta-analysis. BMJ Open. 2021;11(8):e043860. https://doi.org/10.1136/bmjopen-2020-043860
  38. Hirano I, Dellon ES, Hamilton JD, et al. Efficacy of Dupilumab in a Phase 2 Randomized Trial of Adults with Active Eosinophilic Esophagitis. Gastroenterology. 2020;158(1):111-122.e10.  https://doi.org/10.1053/j.gastro.2019.09.042
  39. Dellon ES, Rothenberg ME, Collins MH, et al. Dupilumab in Adults and Adolescents with Eosinophilic Esophagitis. The New England Journal of Medicine. 2022;387(25):2317-2330. https://doi.org/10.1056/NEJMoa2205982
Contact the author
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

Email Confirmation

An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

Email Confirmation

Contact us
If you have any questions, complaints or suggestions, please use this feedback form.
Email
Message
The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
Submit Application

You can become an author of one of our magazines, send a request and we will consider it in during the day.

Name
Phone
E-mail
Message
Login
Registration
E-mail
Password
Forgot Password?

Log in to the site using your account in one of the services

Password recovery
E-mail
Login
Register

We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.