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Neshkova E.A.

National Medical Research Center for Therapy and Preventive Medicine

Metelskaya V.A.

National Medical Research Center for Therapy and Preventive Medicine;
Russian Medical Academy of Continuous Professional Education

Timofeev Yu.S.

National Medical Research Center for Therapy and Preventive Medicine

Dubovskaya N.I.

National Medical Research Center for Therapy and Preventive Medicine

Smirnova M.I.

National Medical Research Center for Therapy and Preventive Medicine

Dzhioeva O.N.

National Medical Research Center for Therapy and Preventive Medicine

Drapkina O.M.

National Medical Research Center for Therapy and Preventive Medicine

Neutrophil elastase as a promising biomarker of low-grade inflammation in chronic non-communicable diseases

Authors:

Neshkova E.A., Metelskaya V.A., Timofeev Yu.S., Dubovskaya N.I., Smirnova M.I., Dzhioeva O.N., Drapkina O.M.

More about the authors

Journal: Russian Journal of Preventive Medicine. 2025;28(4): 142‑148

DOI: 10.17116/profmed202528041142

Read: 1896 times

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Table of contents

NEUTROPHIL ELASTASE AS A PROMISING BIOMARKER OF LOW-GRADE INFLAMMATION IN CHRONIC NON-COMMUNICABLE DISEASES
NEUTROPHIL ELASTASE AS A PROMISING BIOMARKER OF LOW-GRADE INFLAMMATION IN CHRONIC NON-COMMUNICABLE DISEASES

To cite this article:

Neshkova EA, Metelskaya VA, Timofeev YuS, Dubovskaya NI, Smirnova MI, Dzhioeva ON, Drapkina OM. Neutrophil elastase as a promising biomarker of low-grade inflammation in chronic non-communicable diseases. Russian Journal of Preventive Medicine. 2025;28(4):142‑148. (In Russ.)
https://doi.org/10.17116/profmed202528041142

 
Подписка 2026 Профилактическая медицина (Russian Journal of Preventive Medicine)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

The pathogenesis of many chronic non-communicable diseases (NCDs) is associated with chronic low-grade (low-intensity) inflammation. One of the most important mechanisms in the development of inflammation is the activation of the proteolysis system, which regulates biological processes through post-translational modification of proteins. A clinically significant proteolytic enzyme is neutrophil elastase (NE), which belongs to the GASPIDs (Granule-Associated Serine Peptidases of Immune Defense). In inflammation, NE exerts its catalytic activity and damaging potential, acting on a wide range of structural and regulatory proteins, thus participating in the pathogenesis of several NCDs. The most commonly used scientific and clinical laboratory methods for assessing NE, both circulating and complexed with an inhibitor, are reviewed.

OBJECTIVE

To analyze Russian and foreign publications on the relationship between neutrophil elastase and chronic non-communicable diseases and the prospects for using neutrophil elastase as a biomarker of low-grade inflammation in these diseases.

MATERIALS AND METHODS

The literature search was performed in the eLibrary.ru and PubMed databases using the keywords neutrophil elastase, biomarkers, biomarker analysis methods, and chronic non-communicable diseases.

RESULTS

The biochemical structure is analyzed, and the main functions and mechanisms of NE-mediated inflammation regulation in NCDs are presented. The test methods for NE activity and level and the possibilities and conditions for their use in scientific and clinical laboratory practice are discussed.

CONCLUSION

The role of neutrophil elastase in the pathogenesis of several chronic non-infectious diseases and significant change of its level/activity in the blood serum of patients compared to those of control groups support using this enzyme as a promising biomarker predicting the risk of these diseases and their complications.

Keywords:

neutrophilic elastase
chronic obstructive pulmonary disease (COPD)
asthma
atherosclerosis
enzyme-linked immunosorbent assay (ELISA)
kinetic methods

Authors:

Neshkova E.A.

National Medical Research Center for Therapy and Preventive Medicine

Metelskaya V.A.

National Medical Research Center for Therapy and Preventive Medicine;
Russian Medical Academy of Continuous Professional Education

Timofeev Yu.S.

National Medical Research Center for Therapy and Preventive Medicine

Dubovskaya N.I.

National Medical Research Center for Therapy and Preventive Medicine

Smirnova M.I.

National Medical Research Center for Therapy and Preventive Medicine

Dzhioeva O.N.

National Medical Research Center for Therapy and Preventive Medicine

Drapkina O.M.

National Medical Research Center for Therapy and Preventive Medicine

Received:

11.01.2025

Accepted:

06.02.2025

Close metadata

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