Currently, a large number of studies are aimed at studying the delayed post-infection consequences of a new coronavirus infection (COVID-19) in the child population. At the same time, data on the impact of COVID-19 on the functional state of the autonomic nervous system, which largely determines the formation of adaptive potential in children, is not enough.
PURPOSE OF THE STUDY
Based on the study of the parameters of spectral and variational analysis of standard cardiointervalography, to establish features of the functional state of the autonomic nervous system in unvaccinated against COVID-19 children aged 7—17 years, seropositive to the SARS-CoV-2 virus.
MATERIAL AND METHODS
The observation group included 54 children with the presence of specific IgG to SARS-CoV-2, the comparison group included 24 children seronegative to the SARS-CoV-2 virus. The presence of IgG class antibodies to SARS-CoV-2 coronavirus proteins was determined using a set of reagents for enzyme immunoassay «SARS-CoV-2-IgG-Vector». A comparative study of the parameters of the spectral and variational analysis of standard cardiointervalography (CIG) and the results of laboratory studies was performed. Statistical and mathematical analysis was carried out using the Jamovi 1.6.23.0 application.
RESULTS
As a result of a comparative analysis of the main parameters of CIG, performed with a clinoorthostatic test, statistically significant intergroup differences were established in the structure of the frequency components of the CIG spectrum (p=0.025), however, statistically significant causal relationships between the statistical ranks of the immune response to the SARS-CoV-2 virus and quantitative parameters of CIG, as well as the structure of the spectrum power, rhythmogram class, the state of the initial vegetative tone and vegetative reactivity were not established (p=0.104—0.602).
CONCLUSION
As a result of the study, which corresponds in accuracy to an approximate acquaintance, marker indicators of cardiointervalography for detecting post-covid disorders of the autonomic nervous system in unvaccinated children with seroconversion to the SARS-CoV-2 virus have not been established, which necessitates further study.
