Biome depletion hypothesis and ulcerative colitis

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PURPOSE OF THE STUDY

To assess the significance of surrogate markers of the biome depletion hypothesis in the development of ulcerative colitis.

MATERIAL AND METHODS

Active questioning (interviews) of 81 patients with ulcerative colitis and 39 healthy respondents was carried out. The main surrogate markers of the biome depletion hypothesis have been investigated. The information about the family history was analyzed.

RESULTS

The following factors are significant in the development of ulcerative colitis: insufficient intake of vegetables and fruits; increased consumption of sugar with tea and/or coffee; emotional and mental stress. More than ¹/₂ of the patients directly associated the onset of the disease with the stress they suffered. Patients with ulcerative colitis indicated that their close relatives (parents, siblings) were significantly more likely to suffer from autoimmune and oncological diseases of various localization compared with healthy responders.

CONCLUSION

The study confirms that modern diet and lifestyle habits contribute to the development of ulcerative colitis. Confirmation of the biome depletion hypothesis requires further investigations.

Keywords:

ulcerative colitis

biome depletion

intestinal microbiota

Authors:

Bikbavova G.R.

Omsk State Medical University

Livzan M.A.

Omsk State Medical University

ORCID: 0000-0002-6581-7017

Turchaninov D.V.

Omsk State Medical University

Tretyakova T.V.

Omsk Regional Clinical Hospital

Received:

20.03.2020

Accepted:

02.06.2020

List of references:

Structure, function and diversity of the healthy human microbiome. Consortium HMP. Nature. 2012;486:207-214. https://doi.org/10.1038/nature11234
Khalif IL, Loranskaya ID. Inflammatory bowel diseases (ulcerative colitis and Crohn’s disease). Clinical presentation, diagnosis and treatment. M.: Miklosh; 2004. (In Russ.).
Koren O, Knights D, Gonzalez A, Waldron L, Segata N, Knight R, Huttenhower C, Ley RF. A guide to enterotypes across the human body: meta-analysis of microbial community structures in human microbiome datasets. PLoS Computational Biology. 2013;9(1):e1002863. https://doi.org/10.1371/journal.pcbi.1002863
Childers RE, Eluri S, Vazquez C, Weise RM, Bayless TM, Hutfless S. Family history of inflammatory bowel disease among patients with ulcerative colitis: a systematic review and meta-analysis. Crohns Colitis. 2014;8(11):1480-1497. https://doi.org/10.1016/j.crohns.2014.05.008
Ordás I, Eckmann L, Talamini M, Baumgart DC, Sandborn WJ. Ulcerative colitis. Lancet. 2012;380(9853):1606-1619. https://doi.org/10.1016/S0140-6736(12)60150-0
Konovich EA, Khalif IL, Shapina MV. Immunopathogenesis of inflammatory bowel disease. Russian Journal of Gastroenterology, Hepatology, Coloproctology. 2013;4:69-78. (In Russ.).
Kivity S, Agmon-Levin N, Blank M, Shoenfeld Y. Infections and autoimmunity are friends or foes? Trends Immunol. 2009;30(8):409-414. https://doi.org/10.1016/j.it.2009.05.005
Strachan DP, Taylor EM, Carpenter RG. Family structure, neonatal infection, and hay fever in adolescence. Arch Dis Child. 1996;74(5):422-426. https://doi.org/10.1136/adc.74.5.422
Baron S, Turck D, Leplat C, Merle V, Gower-Rousseau C, Marti R, Yzet T, Lerebours E, Dupas J-L, Debeugny S, Salomez J-L, Cortot A, Colombel J-F. Environmental risk factors in paediatric inflammatory bowel diseases: a population based case control study. Gut. 2005;54(3):357-363. https://doi.org/10.1136/gut.2004.054353
Bikbavova GR, Livzan MA, Lopatina OE. Effect of micronutrient deficiency and dietary habits on the immune response and intestinal microbiocenosis in patients with inflammatory bowel diseases: a review. Farmateka. 2019; 26(2):25-30. (In Russ.).
Li F, Liu X, Wang W, Zhang D. Consumption of vegetables and fruit and the risk of inflammatory bowel disease: a meta-analysis. Eur J Gastroenterol Hepatol. 2015;27(6):623-633. https://doi.org/10.1097/MEG.0000000000000330
Statovci D, Aguilera M, MacSharry J, Melgar S. The impact of western diet and nutrients on the microbiota and immune response at mucosal interfaces. Front Immunol. 2017;28(8):838. https://doi.org/10.3389/fimmu.2017.00838
Yao CK, Muir JG, Gibson PR. Review article: insights into colonic protein fermentation, its modulation and potential health implications. Aliment Pharmacol Ther. 2016;43(2):181-196. https://doi.org/10.1111/apt.13456
Galvez J, Rodriguez-Cabezas ME, Zarzuelo A. Effects of dietary fiber on inflammatory bowel disease. Mol Nutr Food Res. 2005;49(6):601-608. https://doi.org/10.1002/mnfr.200500013
Aleksandrova K, Romero-Mosquera B, Hernandez V. Diet, gut microbiome and epigenetics: emerging links with inflammatory bowel diseases and prospects for management and prevention. Nutrients. 2017;9(9):962. https://doi.org/10.3390/nu9090962
De Filippo C, Cavalieri D, Di Paola M, Ramazzotti M, Poullet JB, Massart S, Collini S, Pieraccini G, Lionetti P. Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa. Proc Natl Acad Sci USA. 2010;107(33):14691-14696. https://doi.org/10.1073/pnas.1005963107
Mawdsley JE, Rampton DS. Psychological stress in IBD: new insights into pathogenic and therapeutic implications. Gut. 2005;54(10):1481-1491. https://doi.org/10.1136/gut.2005.064261
Maunder RG, Levenstein S. The role of stress in the development and clinical course of inflammatory bowel disease: epidemiological evidence. Curr Mol Med. 2008;8(4):247-252. https://doi.org/10.2174/156652408784533832
Gao X, Cao Q, Cheng Y, Zhao D, Wang Z, Yang H, Wu Q, You L, Wang Y, Lin Y, Li X, Wang Y, Bian JS, Sun D, Kong L, Birnbaumer L, Yang Y. Chronic stress promotes colitis by disturbing the gut microbiota and triggering immune system response. Proc Natl Acad Sci USA. 2018;115(13): 2960-2969. https://doi.org/10.1073/pnas.1720696115
Reeder LG, Chapman JM, Coulson AH. Socioenvironmental stress, tranquilizers and cardiovascular disease. Proceedings of the Excerpta Medica International Congress Series. 1968;182:226-238.
Erofeev YuV, Boldyreva MS, Brusentsova AV, Karpov AM, Veinikh PA. Organization and methods of conducting sociological studies of the health of the rural population for information support of the system of social and hygienic monitoring: guidelines. Omsk; 2004. (In Russ.).
Strowig T, Thiemann S, Diefenbach A. Microbiome and Gut Immunity: Innate Immune Cells. In: Haller D. The Gut Microbiome in Health and Disease. Switzerland. 2018. https://doi.org/10.1007/978-3-319-90545-7_8
Mackos AR, Maltz R, Bailey MT. The role of the commensal microbiota in adaptive and maladaptive stressor-induced immunomodulation. Horm Behav. 2017;88:70-78. https://doi.org/10.1016/j.yhbeh.2016.10.006

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