The site of the Media Sphera Publishers contains materials intended solely for healthcare professionals.
By closing this message, you confirm that you are a certified medical professional or a student of a medical educational institution.

Login
EN
+7 (495) 482-4118
+7 (495) 482-4329
+8 800 250-18-12
  • (toll-free number for subscriptions)
    Mon-Fri from 10 a.m. to 6 p.m.

  • © 1998-2026
+7 (495) 482-43-29
EN
All journals
Journal
Year
Year
Search result: 0

Adamyan L.V.

Russian Medical University;
Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Sibirskaya E.V.

Russian University of Medicine;
Morozovskaya Children’s City Clinical Hospital;
Russian Children’s Clinical Hospital — Pirogov Russian National Research Medical University;
Pirogov Russian National Research Medical University

Korotkova S.A.

Morozovskaya Children’s City Clinical Hospital of the Moscow Department of Health

Osipova G.T.

Morozovskaya Children’s City Clinical Hospital of the Moscow Department of Health

Gegraeva D.A.

Morozovskaya Children’s City Clinical Hospital

Kurmangaleeva A.Yu.

Morozovskaya Children’s City Clinical Hospital of the Moscow Department of Health

A rare case of endometrial stromal sarcoma of the cervix and vagina in a 17-year-old patient with abnormal uterine bleeding

Authors:

Adamyan L.V., Sibirskaya E.V., Korotkova S.A., Osipova G.T., Gegraeva D.A., Kurmangaleeva A.Yu.

More about the authors

Journal: Russian Journal of Human Reproduction. 2025;31(2): 86‑91

DOI: 10.17116/repro20253102186

Read: 1961 times

Download PDF (RU)
Contact the author
Table of contents

A RARE CASE OF ENDOMETRIAL STROMAL SARCOMA OF THE CERVIX AND VAGINA IN A 17-YEAR-OLD PATIENT WITH ABNORMAL UTERINE BLEEDING
A RARE CASE OF ENDOMETRIAL STROMAL SARCOMA OF THE CERVIX AND VAGINA IN A 17-YEAR-OLD PATIENT WITH ABNORMAL UTERINE BLEEDING

To cite this article:

Adamyan LV, Sibirskaya EV, Korotkova SA, Osipova GT, Gegraeva DA, Kurmangaleeva AYu. A rare case of endometrial stromal sarcoma of the cervix and vagina in a 17-year-old patient with abnormal uterine bleeding. Russian Journal of Human Reproduction. 2025;31(2):86‑91. (In Russ.)
https://doi.org/10.17116/repro20253102186

Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)
МСФ на ЯМ
Использование инфографики авторами научных работ
Close metadata
Recommended articles:
Dissecting cellulitis of the scalp (Hoffman’s disease): a clinical case. Russian Journal of Clinical Dermatology and Vene­reology. 2025;(1):45-48
Features of differential diagnosis of onco­logical pathology at the outpatient stage. Russian Journal of Preventive Medi­cine. 2025;(2):93-95
Sigmoid-rectal intu­ssusception caused by a giant villous adenoma of the rectum. P.A. Herzen Journal of Onco­logy. 2025;(1):53-57
Schi­zophrenic spectrum diso­rders and Parkinson’s disease. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(3):136-141
Comparative analysis of the effe­ctiveness of therapy for endo­metrial hype­rplasia in women of reproductive age. Russian Bulletin of Obstetrician-Gynecologist. 2025;(2):75-83
Sellar collision tumors: difficulties of preoperative neuroimaging and sele­ction of surgical approach. Case repo­rts and lite­rature review. Burdenko's Journal of Neurosurgery. 2025;(3):75-82
Mela­noma of the maxi­llary sinus mucosa. Stomatology. 2025;(2):82-85
Febrile infe­ction-related epilepsy syndrome. S.S. Korsakov Journal of Neurology and Psychiatry. 2025;(7):34-40
A case of the vaso­spastic angina deve­lopment due to acute myocarditis in the patient. Russian Journal of Preventive Medi­cine. 2025;(8):102-109
Abstract:

This article presents an extremely rare clinical case of high-grade endometrial stromal sarcoma located in the vagina and cervix of a 17-year-old adolescent girl. This case is unique due to the absence of available medical literature on similar disease localization and progression in adolescents.

Keywords:

endometrial stromal tumors
abnormal uterine bleeding
uterine cervical neoplasms
vaginal neoplasms
case report

Authors:

Adamyan L.V.

Russian Medical University;
Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Sibirskaya E.V.

Russian University of Medicine;
Morozovskaya Children’s City Clinical Hospital;
Russian Children’s Clinical Hospital — Pirogov Russian National Research Medical University;
Pirogov Russian National Research Medical University

Korotkova S.A.

Morozovskaya Children’s City Clinical Hospital of the Moscow Department of Health

Osipova G.T.

Morozovskaya Children’s City Clinical Hospital of the Moscow Department of Health

Gegraeva D.A.

Morozovskaya Children’s City Clinical Hospital

Kurmangaleeva A.Yu.

Morozovskaya Children’s City Clinical Hospital of the Moscow Department of Health

Received:

05.06.2024

Accepted:

30.07.2024

Close metadata

References:

  1. Santos P, Cunha TM. Uterine sarcomas: clinical presentation and MRI features. Diagnostic and Interventional Radiology. 2015;21(1):4-9.  https://doi.org/10.5152/dir.2014.14053
  2. McCluggage WG, Singh N, Gilks CB. Key changes to the World Health Organization (WHO) classification of female genital tumours introduced in the 5th edition (2020). Histopathology. 2022;80(5):762-778.  https://doi.org/10.1111/his.14609
  3. Jain R, Batra S, Ahmad A, Elahi AA, Gupta M, Saith P. Low grade endometrial stromal sarcoma: a case report. Iranian Journal of Medical Sciences. 2015;40(1):81-84. 
  4. Wu H, Luo Y, Yin N, Gui W, Cao Y. Vaginal endometrial stromal sarcoma: A literature review. European Journal of Obstetrics and Gynecoly and Reproductive Biology. 2019;4:100094. https://doi.org/10.1016/j.eurox.2019.100094
  5. Adamyan LV, Sibirskaya EV, Koltunov IE, Loginova ON, Tarbaya NO, Osipova GT, Pakhomova PI. Abnormal uterine bleeding in puberty: diagnosis and treatment (literature review). Russian Journal of Human Reproduction. 2016;22(6):89-97. (In Russ.). https://doi.org/10.17116/repro201622689-97
  6. Sibirskaya EV, Kurmangaleeva AYu, Korotkova SA, Osipova GT. Abnormal uterine bleeding and COVID-19 (literature review). Russian Journal of Human Reproduction. 2023;29(3):74-80. (In Russ.). https://doi.org/10.17116/repro20232903174
  7. Pautier P, Nam EJ, Provencher DM, Hamilton AL, Mangili G, Siddiqui NA, Westermann AM, Reed NS, Harter P, Ray-Coquard I. Gynecologic Cancer InterGroup (GCIG) consensus review for high-grade undifferentiated sarcomas of the uterus. International Journal of Gynecological Cancer. 2014;24(3):73-77.  https://doi.org/10.1097/IGC.0000000000000281
  8. Ullah A, Arbindi H, Zola F, Mattox SN, Velasquez Zarate L, Munroe J, Heneidi S, Sharma S, Ghamande S, Kleven DT. Pleomorphic high grade endometrial stromal sarcoma with YWHAE gene amplification may be a novel variant with poor prognosis. International Journal of Clinical and Experimental Pathology. 2022; 15(2):72-78. 
  9. Kurman RJ, Carcangiu ML, Herrington CS, Young RH. WHO classification of tumours of female reproductive organs. 5th edition. Chapter 5: Tumours of the uterine corpus: mesenchymal tumors. Lyon, France: International Agency for Research on Cance; 2014:135-147. 
  10. Mariño-Enriquez A, Lauria A, Przybyl J, Ng TL, Kowalewska M, Debiec-Rychter M, Ganesan R, Sumathi V, George S, McCluggage WG, Nucci MR, Lee CH, Fletcher JA. BCOR Internal Tandem Duplication in High-grade Uterine Sarcomas. American Journal of Surgical Pathology. 2018;42(3):335-341.  https://doi.org/10.1097/PAS.0000000000000993
  11. Rak tela matki i sarkomy matki. Klinicheskie rekomendatsii. M.: Ministerstvo zdravookhraneniya Rossijskoj Federatsii; 2021. (In Russ.). Accessed June 05, 2024. https://oncology-association.ru/wp-content/uploads/2021/02/rak-tela-matki-i-sarkomy-matki-2021.pdf
  12. Koskas M, Morice P, Yazbeck C, Duvillard P, Walker F, Madelenat P. Conservative management of low-grade endometrial stromal sarcoma followed by pregnancy and severe recurrence. Anticancer Research. 2009;29(10):4147-4150.
  13. Kaprin AD, Novikova EG, Mukhtarulina SV. Comparison of different classifications of radical hysterectomies: Complexifying or helping our understanding? Onkologiya. Zhurnal imeni P.A. Gertsena. 2016;5(4):63-71. (In Russ.). https://doi.org/10.17116/onkolog20165463-71
  14. Masand RP, Euscher ED, Deavers MT, Malpica A. Endometrioid stromal sarcoma: a clinicopathologic study of 63 cases. American Journal of Surgical Pathology. 2013;37(11):1635-1647. https://doi.org/110.1097/PAS.0000000000000083
  15. Zhang YY, Li Y, Qin M, Cai Y, Jin Y, Pan LY. High-grade endometrial stromal sarcoma: a retrospective study of factors influencing prognosis. Cancer Management and Research. 2019;11:831-837.  https://doi.org/10.2147/CMAR.S187849
  • Tejada MA, Antunez C, Nunez-Badinez P, De Leo B, Saunders PT, Vincent K, Cano A, Nagel J, Gomez R. Rodent Animal Models of Endometriosis-Associated Pain: Unmet Needs and Resources Available for Improving Translational Research in Endometriosis. International Journal of Molecular Sciences. 2023;24(3):2422. https://doi.org/10.3390/ijms2403242
  • Deseure K, Hans GH. Chronic Constriction Injury of the Rat’s Infraorbital Nerve (IoN-CCI) to Study Trigeminal Neuropathic Pain. Journal of Visualized Experiments. 2015;(103):53167. https://doi.org/10.3791/53167
  • Cordaro M, Trovato Salinaro A, Siracusa R, D\’Amico R, Impellizzeri D, Scuto M, Ontario ML, Interdonato L, Crea R, Fusco R, Cuzzocrea S, Di Paola R, Calabrese V. Hidrox® and Endometriosis: Biochemical Evaluation of Oxidative Stress and Pain. Antioxidants. 2021;10(5):720.  https://doi.org/10.3390/antiox10050720
  • Tejada MA, Santos-Llamas AI, Escriva L, Tarin JJ, Cano A, Fernández-Ramírez MJ, Nunez-Badinez P, De Leo B, Saunders PTK, Vidal V, Barthas F, Vincent K, Sweeney PJ, Sillito RR, Armstrong JD, Nagel J, Gomez R. Identification of Altered Evoked and Non-Evoked Responses in a Heterologous Mouse Model of Endometriosis-Associated Pain. Biomedicines. 2022;10(2):501.  https://doi.org/10.3390/biomedicines10020501
  • Pattison LA, Cloake A, Chakrabarti S, Hilton H, Rickman RH, Higham JP, Meng MY, Paine LW, Dannawi M, Qiu L, Ritoux A, Bulmer DC, Callejo G, Smith ESJ. Digging deeper into pain — an ethological behavior assay correlating well-being in mice with human pain experience. Pain. 2024;165(8):1761-1773. https://doi.org/10.1101/2023.08.18.553862
  • Leung VSY, Benoit-Biancamano MO, Pang DSJ. Performance of behavioral assays: the Rat Grimace Scale, burrowing activity and a composite behavior score to identify visceral pain in an acute and chronic colitis model. Pain Reports. 2019;4(2):e718. https://doi.org/10.1097/PR9.0000000000000712
  • Persoons E, De Clercq K, Van den Eynde C, Pinto SJPC, Luyten K, Van Bree R, Tomassetti C, Voets T, Vriens J. Mimicking Sampson’s Retrograde Menstrual Theory in Rats: A New Rat Model for Ongoing Endometriosis-Associated Pain. International Journal of Molecular Sciences. 2020;21(7):2326. https://doi.org/10.3390/ijms21072326
    • Contact the author
    Email
    Message
    The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.

    Email Confirmation

    An email was sent to test@gmail.com with a confirmation link. Follow the link from the letter to complete the registration on the site.

    Email Confirmation

    Contact us
    If you have any questions, complaints or suggestions, please use this feedback form.
    Email
    Message
    The publishing house "Media Sphere" does not provide treatment services, does not give recommendations on contacting medical institutions and specific specialists, on the prescription of medicines and dietary supplements.
    Submit Application

    You can become an author of one of our magazines, send a request and we will consider it in during the day.

    Name
    Phone
    E-mail
    Message
    Login
    Registration
    E-mail
    Password
    Forgot Password?

    Log in to the site using your account in one of the services

    Password recovery
    E-mail
    Login
    Register

    We use cооkies to improve the performance of the site. By staying on our site, you agree to the terms of use of cооkies. To view our Privacy and Cookie Policy, please. click here.