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Adamyan L.V.

Russian University of Medicine;
Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Mikhaleva L.M.

Avtsyn Research Institute of Human Morphology of the Petrovsky Russian Scientific Center of Surgery

Serezhenkov V.A.

Semenov Institute of Chemical Physics, Russian Academy of Sciences

Tkachev N.A.

Semenov Institute of Chemical Physics, Russian Academy of Sciences

Pivazyan L.G.

Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Mailova K.S.

Russian University of Medicine

Avetisyan J.S.

Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Stepanian A.A.

Academy of Women’s Health and Endoscopic Surgery

Modern view on the experimental creation of endometriosis in animal models (own data)

Authors:

Adamyan L.V., Mikhaleva L.M., Serezhenkov V.A., Tkachev N.A., Pivazyan L.G., Mailova K.S., Avetisyan J.S., Stepanian A.A.

More about the authors

Journal: Russian Journal of Human Reproduction. 2024;30(6): 55‑60

DOI: 10.17116/repro20243006155

Views: 577

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Table of contents

MODERN VIEW ON THE EXPERIMENTAL CREATION OF ENDOMETRIOSIS IN ANIMAL MODELS (OWN DATA)
MODERN VIEW ON THE EXPERIMENTAL CREATION OF ENDOMETRIOSIS IN ANIMAL MODELS (OWN DATA)

To cite this article:

Adamyan LV, Mikhaleva LM, Serezhenkov VA, et al. . Modern view on the experimental creation of endometriosis in animal models (own data). Russian Journal of Human Reproduction. 2024;30(6):55‑60. (In Russ.)
https://doi.org/10.17116/repro20243006155

Подписка 2025-2 (Russian Journal of Human Reproduction)
 
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Endometriosis is a gynecological disease that affects up to 10% of women of reproductive age and is characterized by pronounced heterogeneity of clinical manifestations and pathogenetic mechanisms. Despite significant advances in diagnostics and treatment, key aspects of pathogenesis remain poorly understood, and the effectiveness of existing therapeutic approaches is limited. In this study, an improved experimental model of endometriosis was developed to study in detail the pathophysiological mechanisms and evaluate the effectiveness of new therapeutic agents. This model provides the opportunity to develop personalized treatment and prevention strategies, which is an important step in improving the quality of medical care for patients with this disease.

Keywords:

endometriosis
reproductive medicine
infertility
experiment

Authors:

Adamyan L.V.

Russian University of Medicine;
Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Mikhaleva L.M.

Avtsyn Research Institute of Human Morphology of the Petrovsky Russian Scientific Center of Surgery

Serezhenkov V.A.

Semenov Institute of Chemical Physics, Russian Academy of Sciences

Tkachev N.A.

Semenov Institute of Chemical Physics, Russian Academy of Sciences

Pivazyan L.G.

Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Mailova K.S.

Russian University of Medicine

Avetisyan J.S.

Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Stepanian A.A.

Academy of Women’s Health and Endoscopic Surgery

Received:

15.11.2024

Accepted:

01.12.2024

List of references:

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  2. Adamyan LV, Pivazyan LG, Mailova KS. The role of ferroptosis in the pathogenesis and progression of endometriosis. History of the question and current evidence. Russian Journal of Human Reproduction. 2023;29(5):92-101. (In Russ.). https://doi.org/10.17116/repro20232905192
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  5. Koninckx PR, Ussia A, Guo SW, Saridogan E. The glass ceiling of endometriosis surgeons is research. Facts, Views and Vision in ObGyn. 2024;16(1):1-3.  https://doi.org/10.52054/FVVO.16.1.011
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  10. Adamyan LV, Pivazyan LG, Yurkanova MD, Mailova KS, Stepanyan AA. The role of ferroptosis in reproduction: Modern insights. Russian Journal of Human Reproduction. 2024;30(5):35-45. (In Russ.). https://doi.org/10.17116/repro20243005135
  11. Adamyan L, Pivazyan L, Krylova E, Tarlakyan V, Murvatova K. Iron metabolism markers in peritoneal fluid of patients with endometriosis: systematic review and meta-analysis. Journal of Endometriosis and Uterine Disorders. 2024;5:100061. https://doi.org/10.1016/j.jeud.2024.100061
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  13. Koninckx PR, Ussia A, Adamyan L, Wattiez A, Gomel V, Martin DC. Pathogenesis of endometriosis: the genetic/epigenetic theory. Fertility and Sterility. 2019;111(2):327-340.  https://doi.org/10.1016/j.fertnstert.2018.10.013
  14. Guo SW. Cancer-associated mutations in endometriosis: shedding light on the pathogenesis and pathophysiology. Human Reproduction Update. 2020;26(3):423-449.  https://doi.org/10.1093/humupd/dmz047
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  22. Adamyan L, Aznaurova Y, Stepanian A, Nikitin D, Garazha A, Suntsova M, Sorokin M, Buzdin A. Gene expression signature of endometrial samples from women with and without endometriosis. Journal of Minimally Invasive Gynecology. 2021;28(10):1774-1785. https://doi.org/10.1016/j.jmig.2021.03.011
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  26. Patent na izobretenie RF № RU 2 466 753 C1. Zayavka №2011122537/14. Opublikovano: 2012.11.20. Adamyan LV, Burgova EN, Serezhenkov VA, Zairatyants OV, Arslanyan KN, Sonova MM, Guliev MT, Maksimova YuV. Sposob provedeniya narkoza u krys pri mnogoetapnom eksperimente pri modelirovanii endometrioza. (In Russ.). Accessed November 10, 2024. https://rusneb.ru/catalog/000224_000128_0002466753_20121120_C1_RU
  27. Patent na izobretenie RF. Zayavka 2024106317. Data podachi: 12.03.2024. Adamyan LV, Mailova KS, Pivazyan LG, Tkachev NA, Stepanyan AA. Sposob provedeniya posleoperatsionnoj antibiotikoprofilaktiki vospalitel’nykh izmenenij u krys pri eksperimental’nom modelirovanii endometrioza. (In Russ.).
  28. Burgova EN, Tkachev NA, Adamyan LV, Mikoyan VD, Paklina OV, Stepanyan AA, Vanin AF. Dinitrosyl iron complexes with glutathione suppress experimental endometriosis in rats. European Journal of Pharmacology. 2014;727:140-147.  https://doi.org/10.1016/j.ejphar.2014.01.002
  29. Burgova EN, Tkachev NA, Paklina OV, Mikoyan VD, Adamyan LV, Vanin AF. The effect of dinitrosyl iron complexes with glutathione and S-nitrosoglutathione on the development of experimental endometriosis in rats: a comparative study. European Journal of Pharmacology. 2014;741:37-44.  https://doi.org/10.1016/j.ejphar.2014.07.017
  30. Zairatyants OV, Andreeva EN, Adamyan LV, Sonova MM, Urumova LT, Bolotnikov AI, Ilichev AV, Maldov DG. Endometriosis: new experience in non-hormonal drug therapy. Russian Journal of Human Reproduction. 2018;24(6):113-120. (In Russ.). https://doi.org/10.17116/repro201824061113
  31. Adamyan LV, Burgova EN, Tkachev NA, Mikoyan VD, Stepanyan AA, Sonova MM, Vanin AF. Dinitrosyl iron complexes with glutathione arrest experimental endometriosis in rats. Biofizika. 2013;58(2):302-312. (In Russ.).
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  33. Pepin K, Bologna F, Thalken R, Wilkens M. Endometriosis online communities: how machine learning can help physicians understand what patients are discussing online. Journal of Minimally Invasive Gynecology. https://doi.org/10.1016/j.jmig.2024.08.001
  34. Adamyan LV, Gasparyan SA, Serezhenkov VA, Vanin AF, Burgova EN. Violation of iron binding in endometriosis. Akusherstvo i ginekologiya. 2003;(5):24-27. (In Russ.).
  35. Adamyan LV, Burgova EN, Sonova MM, Osipova AA, Arslanyan KN, Poddubnaya ON. Oxidative stress and genital endometriosis. Russian Journal of Human Reproduction. 2008;(5):37-41. (In Russ.).
  36. Adamyan LV, Burgova EN, Mikoyan VD, Vanin AF, Ionova RM, Cheprasova GP, Gasparyan SA. Violation of the electron transport chain as a manifestation of oxidative stress in endometriosis. Russian Journal of Human Reproduction. 2007;13(5):103-107. (In Russ.).
  37. Burgova EN, Gasparyan SA, Cheprasova GP, Ionova RM, Serezhenkov VA, Vanin AF, Adamyan LV. Significance of active transferrin and ceruloplasmin forms and their correction in genital endometriosis. Russian Journal of Human Reproduction. 2011;17(4):62-66. (In Russ.).
  38. Adamyan LV, Burgova EN, Serezhenkov VA, Sonova MM, Osipova AA, Arslanyan KN, Poddubnaya OM. The role of blood iron-binding proteins in antioxidant protection and their relationship with genital endometriosis. Akusherstvo i ginekologiya. 2009;(5):37-41. (In Russ.).

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