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Adamyan L.V.

Russian University of Medicine;
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Pivazyan L.G.

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Yurkanova M.D.

Sechenov First Moscow State Medical University (Sechenov University)

Mailova K.S.

Russian University of Medicine

Stepanian A.A.

Academy of Women’s Health and Endoscopic Surgery

The role of ferroptosis in reproduction. A modern view of the problem

Authors:

Adamyan L.V., Pivazyan L.G., Yurkanova M.D., Mailova K.S., Stepanian A.A.

More about the authors

Journal: Russian Journal of Human Reproduction. 2024;30(5): 35‑45

DOI: 10.17116/repro20243005135

Views: 1410

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Table of contents

THE ROLE OF FERROPTOSIS IN REPRODUCTION. A MODERN VIEW OF THE PROBLEM
THE ROLE OF FERROPTOSIS IN REPRODUCTION. A MODERN VIEW OF THE PROBLEM

To cite this article:

Adamyan LV, Pivazyan LG, Yurkanova MD, Mailova KS, Stepanian AA. The role of ferroptosis in reproduction. A modern view of the problem. Russian Journal of Human Reproduction. 2024;30(5):35‑45. (In Russ.)
https://doi.org/10.17116/repro20243005135

 
Подписка 2025-2 (Russian Journal of Human Reproduction)
 
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Iron is a vital microelement that is involved in many processes to keep the body healthy. When iron accumulates in excess, reactive oxygen species formation, oxidative stress and cell and tissue damage occur. Ferroptosis is the new form of programmed cell death associated with iron-dependent lipid peroxidation, which occurs when iron metabolism and antioxidant systems are impaired. This process is currently attracting much attention in the study of the mechanisms of many diseases, as well as in the search for new methods of their treatment. Recent studies have emphasized the regulatory mechanisms of ferroptosis in pathological conditions such as premature ovarian insufficiency, endometriosis, intrauterine and peritoneal adhesions. However, the role and mechanisms of ferroptosis in these diseases have not been fully elucidated. Thus, our review reveals the mechanisms of ferroptosis, progress in research on its impact on the development of diseases of the female reproductive system, and currently known methods and markers for its detection.

OBJECTIVE

To identify the role of ferroptosis and iron overload in reproductive medicine, in particular in endometriosis, adhesions and premature ovarian insufficiency, and to describe the molecular mechanisms of ferroptosis involved in the development and progression of these diseases in order to find new methods of their treatment and diagnosis.

Keywords:

ferroptosis
iron
endometriosis
adhesions
premature ovarian insufficiency (POI)
markers

Authors:

Adamyan L.V.

Russian University of Medicine;
Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Pivazyan L.G.

Academician V.I. Kulakov National Medical Research Center for Obstetrics, Gynecology and Perinatology

Yurkanova M.D.

Sechenov First Moscow State Medical University (Sechenov University)

Mailova K.S.

Russian University of Medicine

Stepanian A.A.

Academy of Women’s Health and Endoscopic Surgery

Received:

16.08.2024

Accepted:

04.09.2024

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