In recent years, the prevalence of infertility has been steadily increasing. At the same time, a number of studies indicate that male infertility may be caused by oxidative stress (OS) of sperm, as well as a decrease in the total antioxidant activity of the ejaculate. However, these studies included men with pathogenetic factors for the development of pathozoospermia, which may not be associated with OS. Thus, it is relevant to summarize data on the characteristics of the pathogenetic mechanisms of OS in patients in various clinical groups. Another relevant area of review is to summarize data on the effectiveness of using antioxidant drugs to correct pathozoospermia in patients with OS. The research results of some scientists have demonstrated the effectiveness of myoinositol, D-chiro-inositol, folic acid, manganese and other antioxidants in the correction of pathozoospermia associated with OS. However, on the one hand, the results of these works are partially contradictory; on the other hand, specific treatment groups were not identified, which could distort the final results. In addition, the work addresses the issue of the potential positive effect of inositols on testicular steroidogenesis. Thus, both generalization of the obtained data and further research are required.