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Gumenyuk L.N.

V.I. Vernadsky Crimean Federal University Ministry of Science and Higher Education of the Russian Federation

Dobrokhotova Yu.E.

Federal State Autonomous Educational Institution of Higher Education «N.I. Pirogov Russian National Research Medical University» of the Ministry of Health of the Russian Federation

Puchkina G.A.

V.I. Vernadsky Crimean Federal University Ministry of Science and Higher Education of the Russian Federation

Urezko O.A.

V.I. Vernadsky Crimean Federal University Ministry of Science and Higher Education of the Russian Federation

Kunitsyna E.Yu.

V.I. Vernadsky Crimean Federal University Ministry of Science and Higher Education of the Russian Federation

Stolyarova S.V.

V.I. Vernadsky Crimean Federal University Ministry of Science and Higher Education of the Russian Federation

Koblichenko S.V.

V.I. Vernadsky Crimean Federal University Ministry of Science and Higher Education of the Russian Federation

Changes in the intestinal microbiota and their relationship with some indicators of the cytokine profile in patients with external genital endometriosis

Authors:

Gumenyuk L.N., Dobrokhotova Yu.E., Puchkina G.A., Urezko O.A., Kunitsyna E.Yu., Stolyarova S.V., Koblichenko S.V.

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Journal: Russian Journal of Human Reproduction. 2023;29(6): 87‑94

DOI: 10.17116/repro20232906187

Read: 1369 times

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Table of contents

CHANGES IN THE INTESTINAL MICROBIOTA AND THEIR RELATIONSHIP WITH SOME INDICATORS OF THE CYTOKINE PROFILE IN PATIENTS WITH EXTERNAL GENITAL ENDOMETRIOSIS
CHANGES IN THE INTESTINAL MICROBIOTA AND THEIR RELATIONSHIP WITH SOME INDICATORS OF THE CYTOKINE PROFILE IN PATIENTS WITH EXTERNAL GENITAL ENDOMETRIOSIS

To cite this article:

Gumenyuk LN, Dobrokhotova YuE, Puchkina GA, Urezko OA, Kunitsyna EYu, Stolyarova SV, Koblichenko SV. Changes in the intestinal microbiota and their relationship with some indicators of the cytokine profile in patients with external genital endometriosis. Russian Journal of Human Reproduction. 2023;29(6):87‑94. (In Russ.)
https://doi.org/10.17116/repro20232906187

 
Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Purpose of the study. To study changes in the taxonomic composition of the intestinal microbiota and evaluate at the genus level the nature of their relationship with the levels of IL-6, IL-8 and TNF-α in the blood plasma in patients with external genital endometriosis.

MATERIAL AND METHODS

The composition of the intestinal microbiota in 55 patients with external genital endometriosis (EGE) and 50 healthy women was assessed by 16S ribosomal ribonucleic acid sequencing. The levels of IL-6, IL-8 and TNF-α in blood plasma were studied using enzyme-linked immunosorbent assay. A correlation analysis of the relationship between the number of intestinal bacteria and the levels of IL-6, IL-8 and TNF-α was carried out.

RESULTS

In patients with NGE, changes in the taxonomic composition of the intestinal microbiota were found: a statistically significant decrease in the number of Eubacterium, Coprococcus, Ruminococcus, Bacterioides, Turicibacter, Prevotella and an increase in the number of Shigella. A direct correlation between the abundance of Shigella and the IL-8 index was established, and a reverse correlation between the abundance of Prevotella and Ruminococcus and the TNF-α index.

CONCLUSION

Additional data were obtained on the peculiarities of changes in the intestinal microbiota of patients with external genital endometriosis and the connection of certain genera with plasma levels of IL-8 and TNF-α in this pathology, which may become the basis for further research, as well as for the formation of new approaches to the treatment of external genital endometriosis. endometriosis.

Keywords:

external genital endometriosis
intestinal microbiota
IL-6
IL-8
TNF-α

Authors:

Gumenyuk L.N.

V.I. Vernadsky Crimean Federal University Ministry of Science and Higher Education of the Russian Federation

Dobrokhotova Yu.E.

Federal State Autonomous Educational Institution of Higher Education «N.I. Pirogov Russian National Research Medical University» of the Ministry of Health of the Russian Federation

Puchkina G.A.

V.I. Vernadsky Crimean Federal University Ministry of Science and Higher Education of the Russian Federation

Urezko O.A.

V.I. Vernadsky Crimean Federal University Ministry of Science and Higher Education of the Russian Federation

Kunitsyna E.Yu.

V.I. Vernadsky Crimean Federal University Ministry of Science and Higher Education of the Russian Federation

Stolyarova S.V.

V.I. Vernadsky Crimean Federal University Ministry of Science and Higher Education of the Russian Federation

Koblichenko S.V.

V.I. Vernadsky Crimean Federal University Ministry of Science and Higher Education of the Russian Federation

Received:

08.12.2022

Accepted:

09.01.2023

Close metadata

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