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Sotnikova N.Yu.

Gorodkov Ivanovo Research Institute of Maternity and Childhood

Borzova N.Yu.

Gorodkov Ivanovo Research Institute of Maternity and Childhood

Farzaliyeva A.V.

Gorodkov Ivanovo Research Institute of Maternity and Childhood

Kroshkina N.V.

Ivanovo Research Institute of Motherhood and Childhood named after V.N. Gorodkov

The significance of the monocytes differentiation in the pathogenesis of spontaneous abortion in women with the risk of early miscarriage

Authors:

Sotnikova N.Yu., Borzova N.Yu., Farzaliyeva A.V., Kroshkina N.V.

More about the authors

Journal: Russian Journal of Human Reproduction. 2022;28(4): 25‑30

DOI: 10.17116/repro20222804125

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Table of contents

THE SIGNIFICANCE OF THE MONOCYTES DIFFERENTIATION IN THE PATHOGENESIS OF SPONTANEOUS ABORTION IN WOMEN WITH THE RISK OF EARLY MISCARRIAGE
THE SIGNIFICANCE OF THE MONOCYTES DIFFERENTIATION IN THE PATHOGENESIS OF SPONTANEOUS ABORTION IN WOMEN WITH THE RISK OF EARLY MISCARRIAGE

To cite this article:

Sotnikova NYu, Borzova NYu, Farzaliyeva AV, Kroshkina NV. The significance of the monocytes differentiation in the pathogenesis of spontaneous abortion in women with the risk of early miscarriage. Russian Journal of Human Reproduction. 2022;28(4):25‑30. (In Russ.)
https://doi.org/10.17116/repro20222804125

 
 
Подписка 2025-2 (Russian Journal of Human Reproduction)
 
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OBJECTIVE

To clarify the significance of monocytes differentiation in the pathogenesis of threatened miscarriage in women with threatened early spontaneous abortion on the basis of which to develop the criterion for predicting spontaneous miscarriage.

MATERIAL AND METHODS

115 women were examined at 5-12 weeks of gestation, of these, 80 women with threatened early spontaneous abortion (main group) and 35 women with uncomplicated pregnancy (control group). The relative content of CD14+CD16++ monocytes was determined by flow cytometer method using FACScanto II (Beckton Dickinson, USA). Statistical analysis was carried out using the programs Statistica for Windows 13.0, Microsoft Excel 2010 and MedCalc.

RESULTS

It was shown that women with the threat of abortion had a lower level of CD14+CD16++ monocytes compared to the parameters of the control group. The patients, whose outcome of pregnancy was spontaneous abortion, showed a significant decrease of CD14+CD16++ monocytes compared to similar parameters of pregnant women whose pregnancy ended by delivery at term (p =0.000001).

CONCLUSIONS

It was established, that alternatively activated monocytes play an important role in the pathogenesis of threatened early abortion, and their amount in peripheral blood can be used as a predictor of early abortion in women with threatened miscarriage.

Keywords:

pregnancy
monocytes differentiation
alternatively activated monocytes
the threat of termination of pregnancy
spontaneous abortion

Authors:

Sotnikova N.Yu.

Gorodkov Ivanovo Research Institute of Maternity and Childhood

Borzova N.Yu.

Gorodkov Ivanovo Research Institute of Maternity and Childhood

Farzaliyeva A.V.

Gorodkov Ivanovo Research Institute of Maternity and Childhood

Kroshkina N.V.

Ivanovo Research Institute of Motherhood and Childhood named after V.N. Gorodkov

Received:

26.03.2022

Accepted:

27.06.2022

List of references:

  1. Podzolkova NM, Skvorcova MYu, Denisova TV. Samoproizvol’noe preryvanie beremennosti: sovremennye podhody k diagnostike, lecheniyu i profilaktike. M.: GEOTAR-Media; 2018. (In Russ.).
  2. Magnus MC, Wilcox AJ, Morken NH, Weinberg CR, Håberg SE. Role of maternal age and pregnancy history in risk of miscarriage: prospective register based study. BMJ. 2019;364:l869. https://doi.org/10.1136/bmj.l869
  3. Laviron M, Boissonnas A. Ontogeny of Tumor-Associated Macrophages. Frontiers in Immunology. 2019;10(1799):1-7.  https://doi.org/10.3389/fimmu.2019.01799
  4. Sotnikova NYu, Ansiferova YuS, Kroshkina NV, Voronin DN. The role of innate immune cells in ensuring the success of early pregnancy. Zhurnal akusherstva i zhenskih boleznej. 2013;62(2):151-159. (In Russ.).
  5. Lawrence R, Moonjung J. Neutrophilic Leukocytosis, Neutropenia, Monocytosis, and Monocytopenia. In: Hoffman R, Benz EJ Jr, Silberstein LE, Heslop HE, Weitz JI, Anastasi J, eds. Hematology: Basic Principles and Practice. 7th ed. Elsevier Inc.; 2018: 675-681.  https://doi.org/10.1016/B978-0-323-35762-3.00048-2
  6. Haitov PM. Immunologiya: struktura i funkcii immunnoj sistemy. M.: GEOTAR-Media; 2019. (In Russ.).
  7. Sica A, Mantovani A. Macrophage plasticity and polarization: in vivo veritas. Journal of Clinical Investigation. 2012;122(3):787-795.  https://doi.org/10.1172/JCI59643
  8. Ziegler-Heitbrock L, Ancuta P, Crowe S, Dalod M, Grau V, Hart DN, Leenen PJ, Liu YJ, MacPherson G, Randolph GJ, Scherberich J, Schmitz J, Shortman K, Sozzani S, Strobl H, Zembala M, Austyn JM, Lutz MB. Nomenclature of monocytes and dendritic cells in blood. Blood. 2010;116(16):74-80.  https://doi.org/10.1182/blood-2010-02-258558
  9. Kittan NA, Allen RM, Dhaliwal A, Cavassani KA, Schaller M, Gallagher KA, Carson WF 4th, Mukherjee S, Grembecka J, Cierpicki T, Jarai G, Westwick J, Kunkel SL, Hogaboam CM. Cytokine induced phenotypic and epigenetic signatures are key to establishing specific macrophage phenotypes. PloS One. 2013;8(10):15.  https://doi.org/10.1371/journal.pone.0078045
  10. Coillard A, Segura E. In vivo Differentiation of Human Monocytes. Frontiers in Immunology. 2019;10:1907. https://doi.org/10.3389/fimmu.2019.01907
  11. Faas MM, de Vos P. Maternal monocytes in pregnancy and preeclampsia in humans and in rats. Journal of Reproductive Immunology. 2017;119:91-97.  https://doi.org/10.1016/j.jri.2016.06.009
  12. Lampe R, Kövér Á, Szűcs S, Pál L, Árnyas E, Ádány R, Póka R. Phagocytic index of neutrophil granulocytes and monocytes in healthy and preeclamptic pregnancy. Journal of Reproductive Immunology. 2015;107:26-30.  https://doi.org/10.1016/j.jri.2014.11.001
  13. Murray P.J. Macrophage polarization. Annual Review of Physiology. 2017;79:541-566.  https://doi.org/10.1146/annurev-physiol-022516-034339
  14. Rendell V, Bath NM, Brennan TV. Medawar’s Paradox and immune mechanisms of 460 fetomaternal tolerance. OBM Transplantation. 2020;4(1):26.  https://doi.org/10.21926/obm.transplant.2001104
  15. Zhang Y, He M, Wang Y, Liao AH. Modulators of the Balance between M1 and M2 Macrophages during Pregnancy. Frontiers in Immunology. 2017;8:120.  https://doi.org/10.3389/fimmu.2017.00120
  16. Yao Y, Xu X, Jin L. Macrophage polarization in physiological and pathological pregnancy. Frontiers in Immunology. 2019;10:792.  https://doi.org/10.3389/fimmu.2019.00792
  17. Brown MB, von Chamier M, Allam AB, Reyes L. M1/M2 macrophage polarity in normal and complicated pregnancy. Frontiers in Immunology. 2014;5:606.  https://doi.org/10.3389/fimmu.2014.00606

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