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Sotnikova N.Yu.

Gorodkov Ivanovo Research Institute of Maternity and Childhood

Borzova N.Yu.

Gorodkov Ivanovo Research Institute of Maternity and Childhood

Farzaliyeva A.V.

Gorodkov Ivanovo Research Institute of Maternity and Childhood

Kroshkina N.V.

Ivanovo Research Institute of Motherhood and Childhood named after V.N. Gorodkov

The significance of the monocytes differentiation in the pathogenesis of spontaneous abortion in women with the risk of early miscarriage

Authors:

Sotnikova N.Yu., Borzova N.Yu., Farzaliyeva A.V., Kroshkina N.V.

More about the authors

Journal: Russian Journal of Human Reproduction. 2022;28(4): 25‑30

DOI: 10.17116/repro20222804125

Read: 1749 times

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Table of contents

THE SIGNIFICANCE OF THE MONOCYTES DIFFERENTIATION IN THE PATHOGENESIS OF SPONTANEOUS ABORTION IN WOMEN WITH THE RISK OF EARLY MISCARRIAGE
THE SIGNIFICANCE OF THE MONOCYTES DIFFERENTIATION IN THE PATHOGENESIS OF SPONTANEOUS ABORTION IN WOMEN WITH THE RISK OF EARLY MISCARRIAGE

To cite this article:

Sotnikova NYu, Borzova NYu, Farzaliyeva AV, Kroshkina NV. The significance of the monocytes differentiation in the pathogenesis of spontaneous abortion in women with the risk of early miscarriage. Russian Journal of Human Reproduction. 2022;28(4):25‑30. (In Russ.)
https://doi.org/10.17116/repro20222804125

 
Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)
 
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

OBJECTIVE

To clarify the significance of monocytes differentiation in the pathogenesis of threatened miscarriage in women with threatened early spontaneous abortion on the basis of which to develop the criterion for predicting spontaneous miscarriage.

MATERIAL AND METHODS

115 women were examined at 5-12 weeks of gestation, of these, 80 women with threatened early spontaneous abortion (main group) and 35 women with uncomplicated pregnancy (control group). The relative content of CD14+CD16++ monocytes was determined by flow cytometer method using FACScanto II (Beckton Dickinson, USA). Statistical analysis was carried out using the programs Statistica for Windows 13.0, Microsoft Excel 2010 and MedCalc.

RESULTS

It was shown that women with the threat of abortion had a lower level of CD14+CD16++ monocytes compared to the parameters of the control group. The patients, whose outcome of pregnancy was spontaneous abortion, showed a significant decrease of CD14+CD16++ monocytes compared to similar parameters of pregnant women whose pregnancy ended by delivery at term (p =0.000001).

CONCLUSIONS

It was established, that alternatively activated monocytes play an important role in the pathogenesis of threatened early abortion, and their amount in peripheral blood can be used as a predictor of early abortion in women with threatened miscarriage.

Keywords:

pregnancy
monocytes differentiation
alternatively activated monocytes
the threat of termination of pregnancy
spontaneous abortion

Authors:

Sotnikova N.Yu.

Gorodkov Ivanovo Research Institute of Maternity and Childhood

Borzova N.Yu.

Gorodkov Ivanovo Research Institute of Maternity and Childhood

Farzaliyeva A.V.

Gorodkov Ivanovo Research Institute of Maternity and Childhood

Kroshkina N.V.

Ivanovo Research Institute of Motherhood and Childhood named after V.N. Gorodkov

Received:

26.03.2022

Accepted:

27.06.2022

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References:

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