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Kalinin P.L.

Burdenko Neurosurgery Center

Kutin M.A.

Burdenko Neurosurgery Center

Lubnin A.Yu.

Burdenko Neurosurgical Center

Astafyeva L.I.

Burdenko Neurosurgical Center

Akhvlediani K.N.

Moscow Regional Research Institute of Obstetrics and Gynecology

Ivanov V.V.

Samara State Medical University

Agrba S.B.

Burdenko Neurosurgical Center

Sharipov O.I.

N.N. Burdenko National Medical Research Center of Neurosurgery of the Ministry of Health of the Russian Federation

Fomichev D.V.

N.N. Burdenko National Medical Research Center of Neurosurgery of the Ministry of Health of the Russian Federation

Chernov I.V.

Burdenko Neurosurgical Center

Surgical approaches to the treatment of pituitary adenomas in pregnant women (literature review and clinical observation)

Authors:

Kalinin P.L., Kutin M.A., Lubnin A.Yu., Astafyeva L.I., Akhvlediani K.N., Ivanov V.V., Agrba S.B., Sharipov O.I., Fomichev D.V., Chernov I.V.

More about the authors

Journal: Russian Journal of Human Reproduction. 2022;28(2): 110‑118

Read: 2342 times


To cite this article:

Kalinin PL, Kutin MA, Lubnin AYu, et al. . Surgical approaches to the treatment of pituitary adenomas in pregnant women (literature review and clinical observation). Russian Journal of Human Reproduction. 2022;28(2):110‑118. (In Russ.)
https://doi.org/10.17116/repro202228021110

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References:

  1. Lambert K, Rees K, Seed PT, Dhanjal MK, Knight M, McCance DR, Williamson C. Macroprolactinomas and Nonfunctioning Pituitary Adenomas and Pregnancy Outcomes. Obstetrics and Gynecology. 2017;129(1):185-194.  https://doi.org/10.1097/AOG.0000000000001747
  2. Graillon T, Cuny T, Castinetti F, Courbière B, Cousin M, Albarel F, Morange I, Bruder N, Brue T, Dufour H. Surgical indications for pituitary tumors during pregnancy: a literature review. Pituitary. 2020;23(2):189-199.  https://doi.org/10.1007/s11102-019-01004-3
  3. Ancel PY, Goffinet F; EPIPAGE-2 Writing Group, Kuhn P, Langer B, Matis J, Hernandorena X, Chabanier P, Joly-Pedespan L, Lecomte B, Vendittelli F, Dreyfus M, Guillois B, Burguet A, Sagot P, Sizun J, Beuchée A, Rouget F, Favreau A, Saliba E, Bednarek N, Morville P, Thiriez G, Marpeau L, Marret S, Kayem G, Durrmeyer X, Granier M, Baud O, Jarreau PH, Mitanchez D, Boileau P, Boulot P, Cambonie G, Daudé H, Bédu A, Mons F, Fresson J, Vieux R, Alberge C, Arnaud C, Vayssière C, Truffert P, Pierrat V, Subtil D, D’Ercole C, Gire C, Simeoni U, Bongain A, Sentilhes L, Rozé JC, Gondry J, Leke A, Deiber M, Claris O, Picaud JC, Ego A, Debillon T, Poulichet A, Coliné E, Favre A, Fléchelles O, Samperiz S, Ramful D, Branger B, Benhammou V, Foix-L’Hélias L, Marchand-Martin L, Kaminski M. Survival and morbidity of preterm children born at 22 through 34 weeks’ gestation in France in 2011: results of the EPIPAGE-2 cohort study. JAMA Pediatrics. 2015;169(3):230-238.  https://doi.org/10.1001/jamapediatrics.2014.3351
  4. Ray JG, Vermeulen MJ, Bharatha A, Montanera WJ, Park AL. Association Between MRI Exposure During Pregnancy and Fetal and Childhood Outcomes. JAMA. 2016;316(9):952-961.  https://doi.org/10.1001/jama.2016.12126
  5. Bird ST, Gelperin K, Sahin L, Bleich KB, Fazio-Eynullayeva E, Woods C, Radden E, Greene P, McCloskey C, Johnson T, Shinde M, Krefting I. First-Trimester Exposure to Gadolinium-based Contrast Agents: A Utilization Study of 4.6 Million U.S. Pregnancies. Radiology. 2019;293(1):193-200.  https://doi.org/10.1148/radiol.2019190563
  6. Chansakul T, Young GS. Neuroimaging in Pregnant Women. Seminars in Neurology. 2017;37(6):712-723.  https://doi.org/10.1055/s-0037-1608939
  7. Committee Opinion No. 723: Guidelines for Diagnostic Imaging during Pregnancy and Lactation. Obstetrics and Gynecology. 2017; 130(4):210-216.  https://doi.org/10.1097/AOG.0000000000002355
  8. Reitman E, Flood P. Anaesthetic considerations for non-obstetric surgery during pregnancy. British Journal of Anaesthesia. 2011; 107(suppl 1):72-78.  https://doi.org/10.1093/bja/aer343
  9. Mahajan S, Kumar S, Bhagat H, Chauhan R. Venous Air Embolism during Endoscopic Transsphenoidal Resection of Pituitary Tumor: Need to Be Cautious. Journal of Pediatric Neurosciences. 2021;16(1):85-86.  https://doi.org/10.4103/jpn.JPN_124_19
  10. Newfield P, Albin MS, Chestnut JS, Maroon J. Air embolism during trans-sphenoidal pituitary operations. Neurosurgery. 1978;2(1): 39-42.  https://doi.org/10.1227/00006123-197801000-00008
  11. Carvalho CS, Resende F, Centeno MJ, Ribeiro I, Moreira J. Anesthetic approach of pregnant woman with cerebral arteriovenous malformation and subarachnoid hemorrhage during pregnancy: case report. Brazilian Journal of Anesthesiology. 2013;63(2):223-226.  https://doi.org/10.1016/j.bjane.2012.05.004
  12. Tuncali B, Aksun M, Katircioglu K, Akkol I, Savaci S. Intraoperative fetal heart rate monitoring during emergency neurosurgery in a parturient. Journal of Anesthesia. 2006;20(1):40-43.  https://doi.org/10.1007/s00540-005-0359-4
  13. Kutin MA, Kurnosov AB, Kalinin PL, Fomichev DV, Alekseev SN, Shkarubo AN, Sharipov OI, Strunina YV. The effectiveness of using HyperHAES hypertonic isooncotic plasma solution to achieve stable intracranial hypotension in endoscopic endonasal transsphenoidal adenomectomy as an alternative to the invasive external lumbar drainage. Voprosy neirokhirurgii im. N.N. Burdenko. 2015;79(2): 82-86. (In Russ.). https://doi.org/10.17116/neiro201579282-86
  14. Maiter D. Prolactinoma and pregnancy: From the wish of conception to lactation. Annales D’endocrinologie. 2016;77(2):128-134.  https://doi.org/10.1016/j.ando.2016.04.001
  15. Molitch ME. Pituitary tumors and pregnancy. Growth Hormone and IGF Research. 2003;13(suppl A):38-44.  https://doi.org/10.1016/s1096-6374(03)00054-6
  16. Melmed S, Casanueva FF, Hoffman AR, Kleinberg DL, Montori VM, Schlechte JA, Wass JA; Endocrine Society. Diagnosis and treatment of hyperprolactinemia: an Endocrine Society clinical practice guideline. The Journal of Clinical Endocrinology and Metabolism. 2011;96(2):273-288.  https://doi.org/10.1210/jc.2010-1692
  17. Molitch ME. Endocrinology in pregnancy: management of the pregnant patient with a prolactinoma. European Journal of Endocrinology. 2015;172(5):205-213.  https://doi.org/10.1530/EJE-14-0848
  18. Lindsay JR, Jonklaas J, Oldfield EH, Nieman LK. Cushing’s syndrome during pregnancy: personal experience and review of the literature. The Journal of Clinical Endocrinology and Metabolism. 2005; 90(5):3077-3083. https://doi.org/10.1210/jc.2004-2361
  19. Caimari F, Corcoy R, Webb SM. Cushing’s disease: major difficulties in diagnosis and management during pregnancy. Minerva Endocrinologica. 2018;43(4):435-445.  https://doi.org/10.23736/S0391-1977.18.02803-1
  20. Brue T, Amodru V, Castinetti F. Management of endocrine disease: Management of Cushing’s syndrome during pregnancy: solved and unsolved questions. European Journal of Endocrinology. 2018;178(6): 259-266.  https://doi.org/10.1530/EJE-17-1058
  21. Abbassy M, Kshettry VR, Hamrahian AH, Johnston PC, Dobri GA, Avitsian R, Woodard TD, Recinos PF. Surgical management of recurrent Cushing’s disease in pregnancy: A case report. Surgical Neurology International. 2015;6(suppl 25):640-645.  https://doi.org/10.4103/2152-7806.170472
  22. Casson IF, Davis JC, Jeffreys RV, Silas JH, Williams J, Belchetz PE. Successful management of Cushing’s disease during pregnancy by transsphenoidal adenectomy. Clinical Endocrinology. 1987;27(4): 423-428.  https://doi.org/10.1111/j.1365-2265.1987.tb01169.x
  23. Mellor A, Harvey RD, Pobereskin LH, Sneyd JR. Cushing’s disease treated by trans-sphenoidal selective adenomectomy in mid-pregnancy. British Journal of Anaesthesia. 1998;80(6):850-852.  https://doi.org/10.1093/bja/80.6.850
  24. Ross RJ, Chew SL, Perry L, Erskine K, Medbak S, Afshar F. Diagnosis and selective cure of Cushing’s disease during pregnancy by transsphenoidal surgery. European Journal of Endocrinology. 1995; 132(6):722-726.  https://doi.org/10.1530/eje.0.1320722
  25. Verdugo C, Alegría J, Grant C, Briano E, González MI, Meza H, Amthauer N, Paiva O, Vigueras R, Madariaga J. Cirugía transesfenoidal en enfermedad de Cushing durante gestación [Cushing’s disease treatment with transsphenoidal surgery during pregnancy]. Revista Medica de Chile. 2004;132(1):75-80.  https://doi.org/10.4067/s0034-98872004000100012
  26. Jolly K, Darr A, Arlt W, Ahmed S, Karavitaki N. Surgery for Cushing’s disease in pregnancy: our experience and a literature review. Annals of the Royal College of Surgeons of England. 2019;101(1): 26-31.  https://doi.org/10.1308/rcsann.2018.0175
  27. Lim WH, Torpy DJ, Jeffries WS. The medical management of Cushing’s syndrome during pregnancy. European Journal of Obstetrics, Gynecology, and Reproductive Biology. 2013;168(1):1-6.  https://doi.org/10.1016/j.ejogrb.2012.12.015
  28. Close CF, Mann MC, Watts JF, Taylor KG. ACTH-independent Cushing’s syndrome in pregnancy with spontaneous resolution after delivery: control of the hypercortisolism with metyrapone. Clinical Endocrinology. 1993;39(3):375-379.  https://doi.org/10.1111/j.1365-2265.1993.tb02380.x
  29. Amado JA, Pesquera C, Gonzalez EM, Otero M, Freijanes J, Alvarez A. Successful treatment with ketoconazole of Cushing’s syndrome in pregnancy. Postgraduate Medical Journal. 1990;66(773): 221-223.  https://doi.org/10.1136/pgmj.66.773.221
  30. Berwaerts J, Verhelst J, Mahler C, Abs R. Cushing’s syndrome in pregnancy treated by ketoconazole: case report and review of the literature. Gynecological Endocrinology. 1999;13(3):175-182.  https://doi.org/10.3109/09513599909167552
  31. Sam S, Molitch ME. Timing and special concerns regarding endocrine surgery during pregnancy. Endocrinology and Metabolism Clinics of North America. 2003;32(2):337-354.  https://doi.org/10.1016/s0889-8529(03)00012-4
  32. Herman-Bonert V, Melmed S. Pregnancy and acromegaly, in: M.D. Bronstein (Ed.). Pituitary Tumors and Pregnancy. Kluwer Academic Publishers, Norwell, MA; 2001;109-121. 
  33. Molitch ME. Clinical manifestations of acromegaly. Endocrinology and Metabolism Clinics of North America. 1992;21(3):597-614. 
  34. Chanson P, Vialon M, Caron P. An update on clinical care for pregnant women with acromegaly. Expert Review of Endocrinology and Metabolism. 2019;14(2):85-96.  https://doi.org/10.1080/17446651.2019.1571909
  35. Perdomo CM, Árabe JA, Idoate MÁ, Galofré JC. Management of a pregnant woman with thyrotropinoma: a case report and review of the literature. Gynecological Endocrinology. 2017;33(3):188-192.  https://doi.org/10.1080/09513590.2016.1260110
  36. Tuchmann-Duplessis H. The teratogenic risk. American Journal of Industrial Medicine. 1983;4(1-2):245-258. 
  37. Grand’Maison S, Weber F, Bédard MJ, Mahone M, Godbout A. Pituitary apoplexy in pregnancy: A case series and literature review. Obstetric Medicine. 2015;8(4):177-183.  https://doi.org/10.1177/1753495X15598917
  38. Rajasekaran S, Vanderpump M, Baldeweg S, Drake W, Reddy N, Lanyon M, Markey A, Plant G, Powell M, Sinha S, Wass J. UK guidelines for the management of pituitary apoplexy. Clinical Endocrinology. 2011;74(1):9-20.  https://doi.org/10.1111/j.1365-2265.2010.03913.x
  39. Bachmeier CAE, Snell C, Morton A. Visual loss in pregnancy. BMJ Case Reports. 2019;12(5):e228323. https://doi.org/10.1136/bcr-2018-228323
  40. Rosmino J, Tkatch J, Di Paolo MV, Berner S, Lescano S, Guitelman M. Non-functioning pituitary adenomas and pregnancy: one-center experience and review of the literature. Archives of Endocrinology and Metabolism. 2021;64(5):614-622.  https://doi.org/10.20945/2359-3997000000232
  41. Witek P, Zieliński G, Maksymowicz M, Zgliczyński W. Transsphenoidal surgery for a life-threatening prolactinoma apoplexy during pregnancy. Neuro Endocrinology Letters. 2012;33(5):483-488. 
  42. Tandon A, Alzate J, LaSala P, Fried MP. Endoscopic Endonasal Transsphenoidal Resection for Pituitary Apoplexy during the Third Trimester of Pregnancy. Surgery Research and Practice. 2014;2014: 397131. https://doi.org/10.1155/2014/397131

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