OBJECTIVE

To assess the level of thyroid-stimulating hormone and prolactin in women of young reproductive age with infertility before entering the IVF protocol and the threshold level of hormones at which a favorable outcome of treatment is possible.

MATERIAL AND METHODS

The study sample included 171 patients with a confirmed diagnosis of infertility who applied for IVF and IVF/ICSI in the period from 2016 to 2017. All patients underwent superovulation induction in the IVF and IVF/ICSI program. The serum level of thyroid-stimulating hormone was measured 1 month before the start of the ART procedure. Serum prolactin levels were measured in the follicular phase of the menstrual cycle at the beginning of treatment.

RESULTS

The results of the analysis of statistically significant differences were obtained by comparing the average values of thyroid-stimulating hormone in the group of patients with clinical pregnancy and not having occurred (p<0.05). Lower values of thyroid-stimulating hormone (TSH <2 mIU / ml) significantly correlated with the onset of clinical pregnancy after IVF, as well as with pregnancy, with completed generic TSH level was statistically significant lower than in patients with a conditional pregnancy outcome (p<0.05). When identifying patients with a history of hyperprolactinemia and the diagnosis, there was a relationship indicating the fact that with an increase in prolactin >520 mIU/L, the number of pregnant women (21.4%) was significantly lower (p<.05) than among patients with prolactin values ≤520.0 mIU/L (74.5%).

CONCLUSION

The presented results show that strictly controlled TSH (less than 2 mIU/ml) at the stage of preparation for ART can have a positive effect on the clinical pregnancy after ART. The effect of hyperprolactinemia in patients with anovulatory infertility on the outcome of ART treatment requires further study.