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Samoilova A.V.

Ulyanov Chuvash State University

Gunin A.G.

Ulyanov Chuvash State University

Sidorov A.E.

Ulyanov Chuvash State University

Denisova T.G.

Ulyanov Chuvash State University;
Postgraduate Doctors’ Training Institute

Chernyshov V.V.

Ulyanov Chuvash State University

Smirnova T.L.

Ulyanov Chuvash State University

Actual research trends in etiology and pathogenesis of endometriosis (a review)

Authors:

Samoilova A.V., Gunin A.G., Sidorov A.E., Denisova T.G., Chernyshov V.V., Smirnova T.L.

More about the authors

Journal: Russian Journal of Human Reproduction. 2020;26(5): 118‑132

DOI: 10.17116/repro202026051118

Read: 11307 times

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Table of contents

ACTUAL RESEARCH TRENDS IN ETIOLOGY AND PATHOGENESIS OF ENDOMETRIOSIS (A REVIEW)
ACTUAL RESEARCH TRENDS IN ETIOLOGY AND PATHOGENESIS OF ENDOMETRIOSIS (A REVIEW)

To cite this article:

Samoilova AV, Gunin AG, Sidorov AE, Denisova TG, Chernyshov VV, Smirnova TL. Actual research trends in etiology and pathogenesis of endometriosis (a review). Russian Journal of Human Reproduction. 2020;26(5):118‑132. (In Russ.)
https://doi.org/10.17116/repro202026051118

Подписка 2026 Проблемы репродукции (Russian Journal of Human Reproduction)
МСФ на ЯМ
Использование инфографики авторами научных работ
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Abstract:

Originally described over a hundred years ago, endometriosis is lasting to be one of the most mysterious diseases. This is a gynecological disorder identified by the presence of ectopic endometrial tissue outside the uterus. It affects ~2-10% of women in their reproductive years and is associated with pain, infertility, changes in placentation, immunology, and chronic inflammation of the peritoneal cavity. The basic hypothesis of implanted endometrial cells following retrograde menstruation, angiogenic and/or lymphogenic spread, or the metaplasia theory cannot explain all manifestations of endometriosis. By the present we know well about altered expressions of growth factors, cytokines, adhesion molecules, matrix metalloproteinases, and enzymes for estrogen synthesis and metabolism frequently observed in this condition. This review describes the novel research mainstreams — the cellular, cytochemical, cytogenetic, molecular, genetic, and epigenetic features of endometriotic lesions. A thorough understanding of the pathogenesis and pathophysiology of endometriosis is important to the improvement of diagnostic and treatment approaches for this pathology.

Keywords:

endometriosis
pathogenesis
signaling pathway
exosomes
microRNA
stem cells

Authors:

Samoilova A.V.

Ulyanov Chuvash State University

Gunin A.G.

Ulyanov Chuvash State University

Sidorov A.E.

Ulyanov Chuvash State University

Denisova T.G.

Ulyanov Chuvash State University;
Postgraduate Doctors’ Training Institute

Chernyshov V.V.

Ulyanov Chuvash State University

Smirnova T.L.

Ulyanov Chuvash State University

Received:

19.03.2020

Accepted:

21.07.2020

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