INTRODUCTION

Venous endothelial dysfunction is a key factor in venous insufficiency, which is especially important during pregnancy. Objective: to identify the relationship between the expression of markers of venous endothelial dysfunction and perinatal outcomes in women with chronic venous diseases (CVD). Materials and methods: in the dynamics of pregnancy, 70 women with erased form of CVD were examined. The main (I) group consisted of 30 patients whose newborns showed signs of hypoxia, and the control (II) group consisted of 40 women with healthy children. All patients underwent ultrasound examinations of the veins of the lower extremities and pelvis with an assessment of vascular patency, the condition of the vein valves, and the phenomenon of platelet sludge. The expression of the CUPRA 1, PPBP, and HIF1 genes at 18—20 and 36 weeks was performed using real-time PCR with commercial probes and primers (applied Biosystems) on a CFX96 amplifier (Bioradiation, USA).

RESULTS

A violation of the functional condition of the veins have all the pregnant women of the main group, which was accompanied by the formation of a sludge of platelets of various degrees in venous valves at the most, signs of endothelial dysfunction and venous hypoxia — slowing gene expression of hypoxia HIF1A was 1.4 fold increase in the expression of cell adhesion molecules ICAM-1 1.39 and protrombinovogo protein RRVR in 1.6 times — at all. The women in the control group did not have any abnormalities. Conclusion. The transcription factor HIF1, the cell adhesion molecule ICAM-1, and the prothrombocytic basic protein PPBP can be considered markers of adverse perinatal outcomes in pregnant women with signs of phlebopathy.