Purpose — to study the expression of genes that determine cell proliferation and apoptosis in pregnant women with HPV and to assess the impact of viral infection on vaginal biocenosis in these women. Material and methods. The study examined 82 pregnant women aged 23 to 31 years who were carriers of HPV. All women included in the study underwent quantitative analysis of vaginal biocenosis and determination of HPV serotypes (Femoflor, DNA technology LLC, Russia). The level of mRNA expression of VEGFA, TGFb, BCL-2, BAG1, BAX genes was determined in the epithelial cells of the cervical canal by RT-PCR in real time (reagents and detecting amplifier produced by DNA-Technologiya LLC, Russia) Results. Lactobacillus spp. was detected in the majority of the examined patients, while more than one third of the patients had Eubacterium spp. and facultative anaerobic representatives of microorganisms characteristic of BV, and a quarter-Candida spp. The most common types of HPV WRC were combined with representatives of microorganisms responsible for the development of vaginal dysbiosis. Carrying HPV altered the expression of genes responsible for apoptosis and proliferation. Conclusion. The ability of HPV to change the expression of genes responsible for apoptosis was revealed. Pregnant carriers of HPV WRC have higher levels of VEGFA, TGFb, BCL-2 and BAG1 gene expression. HPV WRC is associated with a number of BV pathogens.